49,006
edits
Difference between revisions of "TFEB-rearranged renal cell carcinoma"
Jump to navigation
Jump to search
TFEB-rearranged renal cell carcinoma (view source)
Revision as of 13:19, 26 March 2024
, 13:19, 26 March 2024no edit summary
m |
|||
| (6 intermediate revisions by the same user not shown) | |||
| Line 11: | Line 11: | ||
| IHC = TFEB +ve (nuclear staining), HMB-45 +ve, TFE3 -ve | | IHC = TFEB +ve (nuclear staining), HMB-45 +ve, TFE3 -ve | ||
| EM = | | EM = | ||
| Molecular = t(6;11)(p21;q12) | | Molecular = TFEB rearrangement, t(6;11)(p21;q12) and others | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Line 31: | Line 31: | ||
| Tx = [[nephrectomy]] | | Tx = [[nephrectomy]] | ||
}} | }} | ||
''' | '''TFEB-rearranged renal cell carcinoma''', also '''TFEB RCC''', is a rare [[renal cell carcinoma]] recognized by the WHO classification.<ref name=pmid36645398>{{cite journal |authors=Alaghehbandan R, Siadat F, Trpkov K |title=What's new in the WHO 2022 classification of kidney tumours? |journal=Pathologica |volume=115 |issue=1 |pages=8–22 |date=February 2022 |pmid=36645398 |pmc=10342217 |doi=10.32074/1591-951X-818 |url=}}</ref><ref name=pmid24877033/> | ||
It was previously known as ''renal tumour with t(6;11) translocation'', also ''t(6;11) renal cell carcinoma''. It was first described in children. | |||
It was added to WHO classification of renal neoplasia in the [[Vancouver classification|2012 Vancouver modification]].<ref name=pmid24025519>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref> | It was added to WHO classification of renal neoplasia in the [[Vancouver classification|2012 Vancouver modification]].<ref name=pmid24025519>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref> | ||
This entity should '''not''' be confused with [[ | This entity should '''not''' be confused with [[ELOC-mutated renal cell carcinoma]] (previously known as ''TCEB1-mutated renal cell carcinoma''). | ||
==General== | ==General== | ||
| Line 56: | Line 56: | ||
*[[Clear cell renal cell carcinoma]] with eosinophilic cytoplasm. | *[[Clear cell renal cell carcinoma]] with eosinophilic cytoplasm. | ||
*Other [[renal tumours with eosinophilic cytoplasm]]. | *Other [[renal tumours with eosinophilic cytoplasm]]. | ||
*[[Biphasic hyalinizing psammomatous renal cell carcinoma]]. | |||
===Images=== | ===Images=== | ||