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Difference between revisions of "Signet ring cell carcinoma"
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*The name comes from the shape of cells. They look like signet rings that are lying flat on the ground and one is looking from above - see microscopic section. | *The name comes from the shape of cells. They look like signet rings that are lying flat on the ground and one is looking from above - see microscopic section. | ||
=== | ===Anatomical Site=== | ||
It may arise from the:<ref>URL: [http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer]. Accessed on: 7 March 2012.</ref> | It may arise from the:<ref>URL: [http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer http://cancerhelp.cancerresearchuk.org/about-cancer/cancer-questions/what-is-a-signet-cell-cancer]. Accessed on: 7 March 2012.</ref> | ||
*[[Esophagus]]. | |||
**>50% signet ring cells - as per a study definition.<ref>URL: [https://clinicaltrials.gov/ct2/show/NCT01824966 https://clinicaltrials.gov/ct2/show/NCT01824966]. Accessed on: April 23, 2022.</ref> | |||
*[[Stomach]]. | *[[Stomach]]. | ||
*[[Small intestine]] | *[[Small intestine]] | ||
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**Muciphages = cytoplasm lightly eosinophilic, multivaculated (classic) or finely reticulated. | **Muciphages = cytoplasm lightly eosinophilic, multivaculated (classic) or finely reticulated. | ||
*[[Gastric xanthoma]]. | *[[Gastric xanthoma]]. | ||
*[[ | *[[Goblet cell adenocarcinoma]] (''crypt cell carcinoma'' or ''goblet cell carcinoid'').<ref name=pmid22933998>{{Cite journal | last1 = Pericleous | first1 = M. | last2 = Lumgair | first2 = H. | last3 = Baneke | first3 = A. | last4 = Morgan-Rowe | first4 = L. | last5 = E Caplin | first5 = M. | last6 = Luong | first6 = TV. | last7 = Thirlwell | first7 = C. | last8 = Gillmore | first8 = R. | last9 = Toumpanakis | first9 = C. | title = Appendiceal goblet cell carcinoid tumour: a case of unexpected lung metastasis. | journal = Case Rep Oncol | volume = 5 | issue = 2 | pages = 332-8 | month = May | year = 2012 | doi = 000339607 | PMID = 22933998 }}</ref> | ||
*Ischemic mucosal changes - cells within the lumen.<ref name=pmid22082777>{{Cite journal | last1 = Dhingra | first1 = S. | last2 = Wang | first2 = H. | title = Nonneoplastic signet-ring cell change in gastrointestinal and biliary tracts: a pitfall for overdiagnosis. | journal = Ann Diagn Pathol | volume = 15 | issue = 6 | pages = 490-6 | month = Dec | year = 2011 | doi = 10.1016/j.anndiagpath.2011.07.006 | PMID = 22082777 }}</ref> | *Ischemic mucosal changes - cells within the lumen.<ref name=pmid22082777>{{Cite journal | last1 = Dhingra | first1 = S. | last2 = Wang | first2 = H. | title = Nonneoplastic signet-ring cell change in gastrointestinal and biliary tracts: a pitfall for overdiagnosis. | journal = Ann Diagn Pathol | volume = 15 | issue = 6 | pages = 490-6 | month = Dec | year = 2011 | doi = 10.1016/j.anndiagpath.2011.07.006 | PMID = 22082777 }}</ref> | ||
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==IHC== | ==IHC== | ||
*AE1/AE3 +ve. | *AE1/AE3 +ve. | ||
*CK7 +ve. | *CK7 +ve (usually). | ||
==See also== | ==See also== | ||