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Difference between revisions of "Renal hybrid oncocytic/chromophobe tumour"
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Renal hybrid oncocytic/chromophobe tumour (view source)
Revision as of 15:12, 20 March 2024
, 20 Marchno edit summary
| (6 intermediate revisions by the same user not shown) | |||
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*Sporadic. | *Sporadic. | ||
*[[Birt–Hogg–Dubé syndrome]]. | *[[Birt–Hogg–Dubé syndrome]]. | ||
*Renal oncocytosis. | *[[Renal oncocytosis]]. | ||
==Microscopic== | ==Microscopic== | ||
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#* Different fields viewed in isolation would be compatible with the different diagnoses. Tumour component do not intermingle. | #* Different fields viewed in isolation would be compatible with the different diagnoses. Tumour component do not intermingle. | ||
# Renal oncocytoma with scattered chromophobe cells. | # Renal oncocytoma with scattered chromophobe cells. | ||
# Large eosinophilic cell with intracytoplasmic vacuoles. | # Large eosinophilic cell with intracytoplasmic vacuoles - this is the evolving entity ''[[eosinophilic vacuolated tumour]]''. | ||
#* Prominent nucleoli ([[ISUP nucleolar grade]] 3). | #* Prominent nucleoli ([[ISUP nucleolar grade]] 3). | ||
#* Perinuclear halos (occasional). | #* Perinuclear halos (occasional). | ||
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*[[Renal oncocytoma]] - may have limited chromophobe-like areas (<=5% of tumour).<ref name=pmid21166703>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Yilmaz | first2 = A. | last3 = Uzer | first3 = D. | last4 = Dishongh | first4 = KM. | last5 = Quick | first5 = CM. | last6 = Bismar | first6 = TA. | last7 = Gokden | first7 = N. | title = Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. | journal = Histopathology | volume = 57 | issue = 6 | pages = 893-906 | month = Dec | year = 2010 | doi = 10.1111/j.1365-2559.2010.03726.x | PMID = 21166703 }}</ref> | *[[Renal oncocytoma]] - may have limited chromophobe-like areas (<=5% of tumour).<ref name=pmid21166703>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Yilmaz | first2 = A. | last3 = Uzer | first3 = D. | last4 = Dishongh | first4 = KM. | last5 = Quick | first5 = CM. | last6 = Bismar | first6 = TA. | last7 = Gokden | first7 = N. | title = Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. | journal = Histopathology | volume = 57 | issue = 6 | pages = 893-906 | month = Dec | year = 2010 | doi = 10.1111/j.1365-2559.2010.03726.x | PMID = 21166703 }}</ref> | ||
*[[Chromophobe renal cell carcinoma]], eosinophilic variant. | *[[Chromophobe renal cell carcinoma]], eosinophilic variant. | ||
*[[SDH-deficient renal cell carcinoma]] | *[[SDH-deficient renal cell carcinoma]] - lower nuclear grade, not nested. | ||
*[[Eosinophilic vacuolated tumour]] - evolving entity. | |||
*Other [[renal tumours with eosinophilic cytoplasm]]. | *Other [[renal tumours with eosinophilic cytoplasm]]. | ||
*[[Renal cell carcinoma, unclassified]]. | *[[Renal cell carcinoma, unclassified]]. | ||
===Images=== | ===Images=== | ||
====Case 1==== | |||
<gallery> | <gallery> | ||
Image: Hybrid tumour of the kidney -- low mag.jpg | HOCT - low mag. | Image: Hybrid tumour of the kidney -- low mag.jpg | HOCT - low mag. (WC) | ||
Image: Hybrid tumour of the kidney -- intermed mag.jpg | HOCT - intermed. mag. | Image: Hybrid tumour of the kidney -- intermed mag.jpg | HOCT - intermed. mag. (WC) | ||
Image: Hybrid tumour of the kidney -- high mag.jpg | HOCT - high mag. | Image: Hybrid tumour of the kidney -- high mag.jpg | HOCT - high mag. (WC) | ||
</gallery> | |||
====Case 2==== | |||
<gallery> | |||
Image: Renal hybrid tumour - 2 -- intermed mag.jpg | HOCT - intermed. mag. (WC) | |||
Image: Renal hybrid tumour - 2 -- high mag.jpg | HOCT - high mag. (WC) | |||
Image: Renal hybrid tumour - 2 -- very high mag.jpg | HOCT - very high mag. (WC) | |||
Image: Renal hybrid tumour - nests - 2 -- intermed mag.jpg | HOCT - intermed. mag. (WC) | |||
Image: Renal hybrid tumour - nests - 2 -- high mag.jpg | HOCT - high mag. (WC) | |||
Image: Renal hybrid tumour - nests - 2 -- very high mag.jpg | HOCT - very high mag. (WC) | |||
</gallery> | </gallery> | ||
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Comment: | Comment: | ||
The tumour may be seen in the context of Birt–Hogg–Dubé syndrome. | |||
</pre> | </pre> | ||
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*[[Renal tumours with eosinophilic cytoplasm]]. | *[[Renal tumours with eosinophilic cytoplasm]]. | ||
*[[Renal oncocytoma]]. | *[[Renal oncocytoma]]. | ||
*[[High-grade oncocytic renal tumour]]. | |||
==References== | ==References== | ||