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Difference between revisions of "Eosinophilic vacuolated tumour"
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| Caption = Micrograph of a high-grade oncocytic tumour of the kidney. [[H&E stain]]. | | Caption = Micrograph of a high-grade oncocytic tumour of the kidney. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = high-grade oncocytic tumour | ||
| Micro = | | Micro = abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles, | ||
round nuclei, [[prominent nucleoli]] ([[ISUP nucleolar grade]] 3), no perinuclear halos | |||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[renal oncocytoma]], [[renal hybrid oncocytic/chromophobe tumour]], [[chromophobe renal cell carcinoma]], other [[renal tumours with eosinophilic cytoplasm]] | | LMDDx = [[renal oncocytoma]], [[renal hybrid oncocytic/chromophobe tumour]], [[chromophobe renal cell carcinoma]], other [[renal tumours with eosinophilic cytoplasm]] | ||
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| IHC = PAX8 +ve, CD117 +ve, CD10 +ve, SDHB +ve, TFE3 -ve | | IHC = PAX8 +ve, CD117 +ve, CD10 +ve, SDHB +ve, TFE3 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = TSC1 or TSC2 mutation | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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| Tx = excision | | Tx = excision | ||
}} | }} | ||
''' | '''Eosinophilic vacuolated tumour''', abbreviated '''EVT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book. | ||
It was previously known as '''high-grade oncocytic tumour''', abbreviated '''HOT'''.<ref name=pmid34521993>{{cite journal |authors=Farcaş M, Gatalica Z, Trpkov K, Swensen J, Zhou M, Alaghehbandan R, Williamson SR, Magi-Galluzzi C, Gill AJ, Tretiakova M, Lopez JI, Montiel DP, Sperga M, Comperat E, Brimo F, Yilmaz A, Siadat F, Sangoi A, Gao Y, Ptákova N, Kuthi L, Pivovarcikova K, Rogala J, Agaimy A, Hartmann A, Fraune C, Rychly B, Hurnik P, Durcansky D, Bonert M, Gakis G, Michal M, Hora M, Hes O |title=Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases |journal=Mod Pathol |volume= |issue= |pages= |date=September 2021 |pmid=34521993 |doi=10.1038/s41379-021-00923-6 |url=}}</ref> | |||
==General== | ==General== | ||
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==IHC== | ==IHC== | ||
Features:<ref name=pmid30232607/> | Features:<ref name=pmid30232607/> | ||
*PAX8 +ve | *PAX8 +ve. | ||
*AE1/AE3 +ve. | *AE1/AE3 +ve. | ||
*CK18 +ve. | *CK18 +ve. | ||
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*Melan A -ve. | *Melan A -ve. | ||
*TFE3 -ve. | *TFE3 -ve. | ||
*[[CD117]] +ve (9 of 14 cases). | |||
Others: | |||
*CD56 +ve.{{fact}} | |||
**Typically negative in [[renal oncocytoma]]. | |||
==Molecular== | |||
*TSC1 or TSC2 mutation - see [[renal neoplasms with TSC/mTOR pathway mutations]]. | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||