Difference between revisions of "Renal cell carcinoma with fibromyomatous stroma"

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'''Renal cell carcinoma with fibromyomatous stroma''', abbreviated '''RCC FMS''', is an evolving subtype of [[renal cell carcinoma]].<ref>{{cite journal |vauthors=Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Hes O |title=Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia |journal=Mod Pathol |volume=34 |issue=6 |pages=1167–1184 |date=June 2021 |pmid=33526874 |doi=10.1038/s41379-021-00737-6 |url=}}</ref>
'''Renal cell carcinoma with fibromyomatous stroma''', abbreviated '''RCC FMS''', is an evolving subtype of [[renal cell carcinoma]].<ref>{{cite journal |vauthors=Trpkov K, Williamson SR, Gill AJ, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Hes O |title=Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia |journal=Mod Pathol |volume=34 |issue=6 |pages=1167–1184 |date=June 2021 |pmid=33526874 |doi=10.1038/s41379-021-00737-6 |url=}}</ref>


==IHC==
===Comparison between some renal tumours with clear cells===
{| class="wikitable sortable"
!Tumour
!CK7
!CD10
!CK34betaE12 (K903)
!GPNMB
|-
|Clear cell renal cell carcinoma
| -ve (may be focal)
| +ve
| -ve
| usu. -ve
|-
|Clear cell papillary renal cell tumour
| +ve (diffuse)
| -ve
| +ve
| -ve<ref name=pmid37661807>{{cite journal |authors=Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A |title=Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others |journal=Am J Surg Pathol |volume=47 |issue=11 |pages=1267–1273 |date=November 2023 |pmid=37661807 |doi=10.1097/PAS.0000000000002117 |url=}}</ref>
|-
|ELOC-mutated renal cell carcinoma
| +ve
| +ve
| -ve
| -ve
|-
|TSC/mTOR-mutated renal cell carcinoma
| +ve
| +ve
| -ve
| +ve
|-
|}




Revision as of 03:06, 20 March 2024

Renal cell carcinoma with fibromyomatous stroma, abbreviated RCC FMS, is an evolving subtype of renal cell carcinoma.[1]


IHC

Comparison between some renal tumours with clear cells

Tumour CK7 CD10 CK34betaE12 (K903) GPNMB
Clear cell renal cell carcinoma -ve (may be focal) +ve -ve usu. -ve
Clear cell papillary renal cell tumour +ve (diffuse) -ve +ve -ve[2]
ELOC-mutated renal cell carcinoma +ve +ve -ve -ve
TSC/mTOR-mutated renal cell carcinoma +ve +ve -ve +ve


See also

References

  1. ↑ "Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia". Mod Pathol 34 (6): 1167–1184. June 2021. doi:10.1038/s41379-021-00737-6. PMID 33526874.
  2. ↑ Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A (November 2023). "Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others". Am J Surg Pathol 47 (11): 1267–1273. doi:10.1097/PAS.0000000000002117. PMID 37661807.
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