Clear cell tumours: Difference between revisions

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[[Image:Hyalinizing clear cell carcinoma - high mag.jpg|thumb|right|[[Hyalinizing clear cell carcinoma]], a rare clear cell tumour. [[H&E stain]]. (WC/Nephron)]]
'''Clear cell tumours''' are found in a number of organs.  Thus, it is important to have a list of 'em in one's head so one doesn't misdiagnose something.
'''Clear cell tumours''' are found in a number of organs.  Thus, it is important to have a list of 'em in one's head so one doesn't misdiagnose something.


==Clear cell in the name==
==Clear cell in the name==
Skin:
===Skin===
*[[Clear cell carcinoma]] of the skin.
*[[Clear cell carcinoma]] of the skin.


Gynecologic tract:
===Gynecologic tract===
*[[Clear cell carcinoma]] of the gynecologic tract.
*[[Clear cell carcinoma]] of the gynecologic tract.


Genitourinary tract:
===Genitourinary tract===
*[[Clear cell renal cell carcinoma]].
*[[Clear cell renal cell carcinoma]].
*[[Clear cell papillary renal cell carcinoma]].
*[[Clear cell papillary renal cell carcinoma]].


Gastrointestinal tract:
===Gastrointestinal tract===
*Clear cell variant of [[hepatocellular carcinoma]].<ref name=pmid10955454>{{Cite journal  | last1 = Murakata | first1 = LA. | last2 = Ishak | first2 = KG. | last3 = Nzeako | first3 = UC. | title = Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma. | journal = Mod Pathol | volume = 13 | issue = 8 | pages = 874-81 | month = Aug | year = 2000 | doi = 10.1038/modpathol.3880156 | PMID = 10955454 }}</ref>
*Clear cell variant of [[hepatocellular carcinoma]].<ref name=pmid10955454>{{Cite journal  | last1 = Murakata | first1 = LA. | last2 = Ishak | first2 = KG. | last3 = Nzeako | first3 = UC. | title = Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma. | journal = Mod Pathol | volume = 13 | issue = 8 | pages = 874-81 | month = Aug | year = 2000 | doi = 10.1038/modpathol.3880156 | PMID = 10955454 }}</ref>


Head and neck pathology:
===Head and neck pathology===
*Clear cell carcinoma of the [[salivary gland]].<ref name=pmid12033955>{{Cite journal  | last1 = Wang | first1 = B. | last2 = Brandwein | first2 = M. | last3 = Gordon | first3 = R. | last4 = Robinson | first4 = R. | last5 = Urken | first5 = M. | last6 = Zarbo | first6 = RJ. | title = Primary salivary clear cell tumors--a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. | journal = Arch Pathol Lab Med | volume = 126 | issue = 6 | pages = 676-85 | month = Jun | year = 2002 | doi = 10.1043/0003-9985(2002)1260676:PSCCTA2.0.CO;2 | PMID = 12033955 }}</ref>
*Clear cell carcinoma of the [[salivary gland]]:<ref name=pmid12033955>{{Cite journal  | last1 = Wang | first1 = B. | last2 = Brandwein | first2 = M. | last3 = Gordon | first3 = R. | last4 = Robinson | first4 = R. | last5 = Urken | first5 = M. | last6 = Zarbo | first6 = RJ. | title = Primary salivary clear cell tumors--a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. | journal = Arch Pathol Lab Med | volume = 126 | issue = 6 | pages = 676-85 | month = Jun | year = 2002 | doi = 10.1043/0003-9985(2002)1260676:PSCCTA2.0.CO;2 | PMID = 12033955 }}</ref>
**Clear cell myoepithelial carcinoma.
**[[Hyalinizing clear cell carcinoma]].


Soft tissue pathology:
===Soft tissue pathology===
*[[Clear cell sarcoma]].
*[[Clear cell sarcoma]].


==Other tumours with clear cytoplasm==
===Neuropathology===
*[[Clear cell meningioma]].
*[[Ependymoma|Clear cell ependymoma]].
 
==Tumours with clear/pale cytoplasm==
*[[Chromophobe renal cell carcinoma]].
*[[Chromophobe renal cell carcinoma]].
*[[Sebaceous carcinoma]].
*[[Sebaceous carcinoma]].
*[[Seminoma]]/[[dysgerminoma]]/[[germinoma]].
*[[Paraganglioma]].
*[[Oligodendroglioma]].
*[[Neurocytoma]].
*[[Epithelial-myoepithelial  carcinoma]].
==An exhaustive differential diagnosis for clear cell tumour==
Adapted from ''Miller'' with modifications:<ref name=miller>Miller RT. (Sep 2013). ''Atlantic Diagnostic Immunohistochemistry Symposium''. St. John's, NL, Canada.</ref>
{| class="wikitable sortable"
! Tumour
! Group
! Notes/comments
|-
| [[Clear cell renal cell carcinoma]]
| Clear cell carcinoma
| 
|-
| [[Clear cell papillary renal cell carcinoma]]
| Clear cell carcinoma
|
|-
| [[Xp11.2 translocation carcinoma]]
| Clear cell carcinoma
|
|-
| [[Lung]]
| Clear cell carcinoma
| 
|-
| [[Pulmonary blastoma]]
| Other
| 
|-
| [[Bladder]]
| Clear cell carcinoma
| 
|-
| [[Clear cell carcinoma of the salivary gland]]
| Clear cell carcinoma
| 
|-
| [[Breast]]
| Clear cell carcinoma
| 
|-
| [[Ovarian clear cell carcinoma]]
| Clear cell carcinoma
| 
|-
| [[Endometrial clear cell carcinoma]]
| Clear cell carcinoma
| 
|-
| [[Paratesticular tissues]]
| Clear cell carcinoma
| 
|-
| [[Adrenal]]
| Clear cell carcinoma
| 
|-
| [[Prostate]]
| Clear cell carcinoma
| 
|-
| [[Hepatocellular carcinoma]]
| Clear cell carcinoma
| 
|-
| [[GI tract]]
| Clear cell carcinoma
| 
|-
| [[Pancreas]]
| Clear cell carcinoma
| 
|-
| [[Clear cell squamous carcinoma]]
| Other carcinomas
| 
|-
| [[Hyalinizing clear cell carcinoma of salivary gland]]
| Other carcinomas
| 
|-
| [[Adnexal clear cell carcinoma with comedonecrosis]]
| Other carcinomas
| 
|-
| [[Clear cell follicular carcinoma of thyroid]]
| Other carcinomas
| 
|-
| [[Acinar cell carcinoma]]
| Other carcinomas
| 
|-
| [[Cholangiocarcinoma]]
| Other carcinomas
|<ref>{{Cite journal  | last1 = Haas | first1 = S. | last2 = Gütgemann | first2 = I. | last3 = Wolff | first3 = M. | last4 = Fischer | first4 = HP. | title = Intrahepatic clear cell cholangiocarcinoma: immunohistochemical aspects in a very rare type of cholangiocarcinoma. | journal = Am J Surg Pathol | volume = 31 | issue = 6 | pages = 902-6 | month = Jun | year = 2007 | doi = 10.1097/PAS.0b013e31802c0c8a | PMID = 17527078 }}</ref>
|-
| [[Atypical bile duct adenoma, clear cell type ]]
| Epithelial lesion
|<ref>{{Cite journal  | last1 = Albores-Saavedra | first1 = J. | last2 = Hoang | first2 = MP. | last3 = Murakata | first3 = LA. | last4 = Sinkre | first4 = P. | last5 = Yaziji | first5 = H. | title = Atypical bile duct adenoma, clear cell type: a previously undescribed tumor of the liver. | journal = Am J Surg Pathol | volume = 25 | issue = 7 | pages = 956-60 | month = Jul | year = 2001 | doi =  | PMID = 11420469 }}</ref>
|-
| [[Clear cell carcinoid]]
| Clear cell neuroendocrine tumours 
| 
|-
| [[Clear cell pancreatic endocrine neoplasm]]
| Clear cell neuroendocrine tumours 
| 
|-
| [[Clear cell medullary carcinoma of the thyroid]]
| Clear cell neuroendocrine tumours 
| 
|-
| [[Clear cell paraganglioma of prostate]]
| Clear cell neuroendocrine tumours 
| 
|-
| [[Clear cell lymphoma]]
| Clear cell Hematolymphoid
| 
|-
| [[Clear cell myeloma]]
| Clear cell Hematolymphoid
| 
|-
| [[Syncytial Hodgkin's lymphoma]]
| Clear cell Hematolymphoid
| 
|-
| [[Seminoma]]
| [[Germ cell tumours]]
| 
|-
| [[Yolk sac tumour]]
| Germ cell tumours
| 
|-
| [[Clear cell sex-cord stromal tumours]]
| Other
| [[Leydig cell tumour]]
|-
| [[Clear cell thymoma]]
| Other
| 
|-
| [[Clear cell mesothelioma]]
| Other
| 
|-
| [[Solid pseudopapillary tumour]] of pancreas
| Other
|<ref>{{Cite journal  | last1 = Albores-Saavedra | first1 = J. | last2 = Simpson | first2 = KW. | last3 = Bilello | first3 = SJ. | title = The clear cell variant of solid pseudopapillary tumor of the pancreas: a previously unrecognized pancreatic neoplasm. | journal = Am J Surg Pathol | volume = 30 | issue = 10 | pages = 1237-42 | month = Oct | year = 2006 | doi = 10.1097/01.pas.0000209849.97787.e0 | PMID = 17001153 }}</ref>
|-
| [[Clear cell oncocytoma of salivary gland]]
| Other epithelial clear cell tumours
| 
|-
| [[Chordoma]]
| Other epithelial clear cell tumours
| 
|-
| [[Giant notochrodal hamartoma]]
| Other epithelial clear cell tumours
| 
|-
| [[Clear cell melanoma]]
| Melanoma
| 
|-
| Clear cell [[PEComa]]s  - "sugar" tumor (lung, heart, pancreas, skin, soft tissue)
| Other
| 
|-
| [[Clear cell sarcoma]]
| mesenchymal tumours
|
|-
| [[Clear cell dermatofibroma]]
| mesenchymal tumours
| 
|-
| [[Clear cell atypical fibroxanthoma]]
| mesenchymal tumours
| 
|-
| [[Clear cell meningioma]]
| mesenchymal tumours
|<ref>{{Cite journal  | last1 = Carlotti | first1 = CG. | last2 = Neder | first2 = L. | last3 = Colli | first3 = BO. | last4 = dos Santos | first4 = MB. | last5 = Garcia | first5 = AS. | last6 = Elias | first6 = J. | last7 = Chimelli | first7 = LC. | title = Clear cell meningioma of the fourth ventricle. | journal = Am J Surg Pathol | volume = 27 | issue = 1 | pages = 131-5 | month = Jan | year = 2003 | doi =  | PMID = 12502936 }}</ref>
|-
| [[Dermal clear cell mesenchymal neoplasm]]
| mesenchymal tumours
|<ref>{{Cite journal  | last1 = Lazar | first1 = AJ. | last2 = Fletcher | first2 = CD. | title = Distinctive dermal clear cell mesenchymal neoplasm: clinicopathologic analysis of five cases. | journal = Am J Dermatopathol | volume = 26 | issue = 4 | pages = 273-9 | month = Aug | year = 2004 | doi =  | PMID = 15249856 }} </ref>
|-
| [[GIST|Clear cell GIST]]
| mesenchymal tumours
| 
|-
| [[Alveolar soft part sarcoma]]
| mesenchymal tumours
| 
|-
| [[Reticular variant of perineurioma]]
| mesenchymal tumours
|EMA +ve
|-
| [[Lipidized fibrous histiocytoma]]
| mesenchymal tumours
|<ref>{{Cite journal  | last1 = Iwata | first1 = J. | last2 = Fletcher | first2 = CD. | title = Lipidized fibrous histiocytoma: clinicopathologic analysis of 22 cases. | journal = Am J Dermatopathol | volume = 22 | issue = 2 | pages = 126-34 | month = Apr | year = 2000 | doi =  | PMID = 10770432 }}</ref>
|-
| [[Clear cell dermatofibroma]]
| mesenchymal tumours
| 
|-
| [[Clear cell or "lipidized" fibrous papule of the nose]]
| mesenchymal tumours
| 
|-
|}


==See also==
==See also==
*[[Clear cell carcinoma]].
*[[Clear cell carcinoma]].
*[[Benign clear cell clusters of the kidney]].


==References==
==References==
Retrieved from "https://librepathology.org/wiki/Clear_cell_tumours"