Difference between revisions of "SMARCA4-deficient sinonasal carcinoma"
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'''SMARCA4-deficient sinonasal carcinoma''' is an emerging type of sinonasal carcinoma.<ref name=pmid31934917>{{cite journal |vauthors=Agaimy A, Jain D, Uddin N, Rooper LM, Bishop JA |title=SMARCA4-deficient Sinonasal Carcinoma: A Series of 10 Cases Expanding the Genetic Spectrum of SWI/SNF-driven Sinonasal Malignancies |journal=Am J Surg Pathol |volume=44 |issue=5 |pages=703–710 |date=May 2020 |pmid=31934917 |doi=10.1097/PAS.0000000000001428 |url=}}</ref> | '''SMARCA4-deficient sinonasal carcinoma''' is an emerging type of sinonasal carcinoma.<ref name=pmid31934917>{{cite journal |vauthors=Agaimy A, Jain D, Uddin N, Rooper LM, Bishop JA |title=SMARCA4-deficient Sinonasal Carcinoma: A Series of 10 Cases Expanding the Genetic Spectrum of SWI/SNF-driven Sinonasal Malignancies |journal=Am J Surg Pathol |volume=44 |issue=5 |pages=703–710 |date=May 2020 |pmid=31934917 |doi=10.1097/PAS.0000000000001428 |url=}}</ref> | ||
==General== | |||
*Evolving entity - previously diagnosed as [[SNUC]], [[neuroendocrine carcinoma]].<ref name=pmid34871352>{{cite journal |authors=Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D |title=SMARCA4/BRG1-Deficient Sinonasal Carcinoma |journal=Arch Pathol Lab Med |volume=146 |issue=9 |pages=1122–1130 |date=September 2022 |pmid=34871352 |doi=10.5858/arpa.2021-0001-OA |url=}}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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*Poorly differentiated tumour with large or small cells. | *Poorly differentiated tumour with large or small cells. | ||
DDx:<ref>{{cite journal |authors=Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D |title=SMARCA4/BRG1-Deficient Sinonasal Carcinoma |journal=Arch Pathol Lab Med |volume=146 |issue=9 |pages=1122–1130 |date=September 2022 |pmid=34871352 |doi=10.5858/arpa.2021-0001-OA |url=}}</ref> | DDx:<ref name=pmid34871352>{{cite journal |authors=Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D |title=SMARCA4/BRG1-Deficient Sinonasal Carcinoma |journal=Arch Pathol Lab Med |volume=146 |issue=9 |pages=1122–1130 |date=September 2022 |pmid=34871352 |doi=10.5858/arpa.2021-0001-OA |url=}}</ref> | ||
*[[Sinonasal undifferentiated carcinoma]] (SNUC). | *[[Sinonasal undifferentiated carcinoma]] (SNUC). | ||
*Neuroendocrine carcinoma - [[small cell carcinoma]] and [[large cell neuroendocrine carcinoma]]. | *Neuroendocrine carcinoma - [[small cell carcinoma]] and [[large cell neuroendocrine carcinoma]]. | ||
Revision as of 16:13, 20 December 2023
SMARCA4-deficient sinonasal carcinoma is an emerging type of sinonasal carcinoma.[1]
General
- Evolving entity - previously diagnosed as SNUC, neuroendocrine carcinoma.[2]
Microscopic
Features:
- Poorly differentiated tumour with large or small cells.
DDx:[2]
- Sinonasal undifferentiated carcinoma (SNUC).
- Neuroendocrine carcinoma - small cell carcinoma and large cell neuroendocrine carcinoma.
- Teratocarcinosarcoma.
IHC
Features:[1]
- SMARCA4 loss of staining - definitional.
- CK5 -ve.
- p63 -ve.
- p16 -ve.
- NUT -ve.
See also
- Head and neck pathology.
- SMARCA4.
- SMARCB1 (INI-1).
References
- ↑ 1.0 1.1 "SMARCA4-deficient Sinonasal Carcinoma: A Series of 10 Cases Expanding the Genetic Spectrum of SWI/SNF-driven Sinonasal Malignancies". Am J Surg Pathol 44 (5): 703–710. May 2020. doi:10.1097/PAS.0000000000001428. PMID 31934917.
- ↑ 2.0 2.1 Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D (September 2022). "SMARCA4/BRG1-Deficient Sinonasal Carcinoma". Arch Pathol Lab Med 146 (9): 1122–1130. doi:10.5858/arpa.2021-0001-OA. PMID 34871352.