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Difference between revisions of "Pilomatricoma"
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| Micro = "ghost" cells, foreign body-type giant cells | | Micro = "ghost" cells, foreign body-type giant cells | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[squamous cell carcinoma]], pilomatrix carcinoma, [[basal cell carcinoma]], [[epidermal inclusion cyst]] | | LMDDx = [[squamous cell carcinoma]], pilomatrix carcinoma, [[basal cell carcinoma]], [[epidermal inclusion cyst]], [[heterotopic ossification]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = skin nodule, hard | ||
| Grossing = | | Grossing = | ||
| Site = [[skin]] | | Site = [[skin]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = common in children | ||
| Signs = hard nodule | | Signs = hard nodule | ||
| Symptoms = +/-painful | | Symptoms = +/-painful | ||
| Prevalence = | | Prevalence = common | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
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| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = surgical excision | ||
}} | }} | ||
'''Pilomatricoma''' is a benign [[skin]] lesion that is common in childhood. It may be spelled '''pilomatrixoma'''. | '''Pilomatricoma''' is a benign [[skin]] lesion that is common in childhood. It may be spelled '''pilomatrixoma'''. | ||
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Treatment: | Treatment: | ||
*Surgical excision.<ref name=emed1058965>[http://emedicine.medscape.com/article/1058965-overview http://emedicine.medscape.com/article/1058965-overview]</ref> | *Surgical excision.<ref name=emed1058965>URL: [http://emedicine.medscape.com/article/1058965-overview http://emedicine.medscape.com/article/1058965-overview]. Accessed on: 10 September 2011.</ref> | ||
==Microscopic== | ==Microscopic== | ||
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Notes: | Notes: | ||
*Keratin a prominent feature on cytology - lots of orange stuff. | *Keratin a prominent feature on cytology - lots of orange stuff. | ||
*May ossify. | *May (extensively) ossify.<ref name=pmid20439187>{{Cite journal | last1 = Ioannidis | first1 = O. | last2 = Stavrakis | first2 = T. | last3 = Cheva | first3 = A. | last4 = Papadimitriou | first4 = N. | last5 = Kotronis | first5 = A. | last6 = Kakoutis | first6 = E. | last7 = Makrantonakis | first7 = N. | title = Pilomatricoma of the arm with extensive ossification. | journal = Adv Med Sci | volume = 55 | issue = 2 | pages = 340-2 | month = | year = 2010 | doi = 10.2478/v10039-010-0010-y | PMID = 20439187 }}</ref> | ||
DDx: | DDx: | ||
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*[[Squamous cell carcinoma]]. | *[[Squamous cell carcinoma]]. | ||
*[[Basal cell carcinoma]]. | *[[Basal cell carcinoma]]. | ||
*[[Heterotopic ossification]]. | |||
===Images=== | ===Images=== | ||
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==Sign out== | ==Sign out== | ||
<pre> | |||
Skin Lesion, Left Forearm, Excision: | |||
- Pilomatricoma with ossification. | |||
</pre> | |||
===Block letters=== | |||
<pre> | <pre> | ||
SKIN LESION, RIGHT ARM, EXCISION: | SKIN LESION, RIGHT ARM, EXCISION: | ||
- PILOMATRICOMA. | - PILOMATRICOMA. | ||
</pre> | </pre> | ||
===Micro=== | |||
The sections show anucleate squamous cells ("ghost cells") and multinucleated giant cells. No calcification is present. | |||
No significant nuclear atypia is present. No mitotic activity is apparent. | |||
There is also mildly inflamed fibroadipose tissue and some benign squamous mucosa. | |||
====Alternate==== | |||
The sections show anucleate squamous cells ("ghost cells") and multinucleated giant cells. Calcification is present. No significant nuclear atypia is present. No mitotic activity is apparent. The lesion extends to the inked surface. No skin is present. | |||
==See also== | ==See also== | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Dermatopathology]] | |||