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Difference between revisions of "Pheochromocytoma"
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Memory device - the rule of 10s:<ref name=Ref_PCPBoD8_586>{{Ref PCPBoD8|586}}</ref> | Memory device - the rule of 10s:<ref name=Ref_PCPBoD8_586>{{Ref PCPBoD8|586}}</ref> | ||
*10% extra-adrenal (e.g. carotid body, | *10% extra-adrenal (e.g. carotid body, ''Organ of Zuckerkandl'' (neighourhood of aortic bifuration/IMA branch point)). | ||
*10% bilateral. | *10% bilateral. | ||
*10% malignant. | *10% malignant. | ||
| Line 152: | Line 152: | ||
*Inhibin -ve. | *Inhibin -ve. | ||
**Positive in ACC. | **Positive in ACC. | ||
*Calretinin -ve. | *[[Calretinin]] -ve. | ||
**Positive in ACC. | **Positive in ACC. | ||
A panel: | A panel: | ||
*S-100, chromogranin, | *S-100, chromogranin, calretinin, EMA, PAX8. | ||
==[[Electron microscopy]]== | ==[[Electron microscopy]]== | ||
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==Sign out== | ==Sign out== | ||
Mete ''et al.''. created a synoptic report for these cases that may be used.<ref name=pmid24476517>{{cite journal |authors=Mete O, Tischler AS, de Krijger R, McNicol AM, Eisenhofer G, Pacak K, Ezzat S, Asa SL |title=Protocol for the examination of specimens from patients with pheochromocytomas and extra-adrenal paragangliomas |journal=Arch Pathol Lab Med |volume=138 |issue=2 |pages=182–8 |date=February 2014 |pmid=24476517 |pmc=3909881 |doi=10.5858/arpa.2012-0551-OA |url=}}</ref> The ''College of American Pathologists'' does ''not'' have a [[CAP protocols|synoptic]] for these currently (September 2021).{{fact}} | |||
<pre> | |||
Right Adrenal (Mass), Adrenalectomy: | |||
- Pheochromocytoma, margin clear. | |||
Comment: | |||
The tumour stains as follows: | |||
POSITIVE: synaptophysin, chromogranin A, S-100 (sustentacular cells). | |||
NEGATIVE: EMA, inhibin. | |||
Proliferation (Ki-67): <2% of tumour cells. | |||
The immunostaining pattern is consistent with a pheochromocytoma. | |||
</pre> | |||
===Block letters=== | |||
<pre> | <pre> | ||
ADRENAL MASS, RIGHT, ADRENALECTOMY: | ADRENAL MASS, RIGHT, ADRENALECTOMY: | ||