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Difference between revisions of "C-cell hyperplasia"
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| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = not apparent | | Gross = not apparent; mid portion of lobe to upper third of lobe | ||
| Grossing = | | Grossing = | ||
| Site = [[thyroid gland]] | | Site = [[thyroid gland]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = [[Multiple endocrine neoplasia type 2A]] | | Syndromes = [[Multiple endocrine neoplasia type 2A]], [[Multiple endocrine neoplasia type 2B]] | ||
| Clinicalhx = | | Clinicalhx = +/-family history of thyroid cancer or MEN 2A or MEN 2B | ||
| Signs = | | Signs = +/-marfanoid habitus (seen in MEN 2B) | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = uncommon | | Prevalence = uncommon | ||
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| Prognosis = benign in itself | | Prognosis = benign in itself | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = prophylatic surgery | | Tx = prophylatic surgery | ||
}} | }} | ||
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==General== | ==General== | ||
*Screening for C-cell hyperplasia/[[medullary thyroid carcinoma]] done with ''serum calcitonin level''.<ref name=pmid19726541>{{cite journal |author=Machens A, Hoffmann F, Sekulla C, Dralle H |title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer |journal=Endocr. Relat. Cancer |volume=16 |issue=4 |pages=1291–8 |year=2009 |month=December |pmid=19726541 |doi=10.1677/ERC-09-0136 |url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref> | *Screening for C-cell hyperplasia/[[medullary thyroid carcinoma]] done with ''serum calcitonin level''.<ref name=pmid19726541>{{cite journal |author=Machens A, Hoffmann F, Sekulla C, Dralle H |title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer |journal=Endocr. Relat. Cancer |volume=16 |issue=4 |pages=1291–8 |year=2009 |month=December |pmid=19726541 |doi=10.1677/ERC-09-0136 |url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref> | ||
Associated with: | |||
*[[Multiple endocrine neoplasia type 2A]]<ref name=pmid21134882>{{Cite journal | last1 = Tyer | first1 = NM. | last2 = Braunstein | first2 = GD. | last3 = Frishberg | first3 = D. | title = Unusual case of multiple endocrine neoplasia type 2A syndrome without medullary thyroid carcinoma. | journal = Endocr Pract | volume = 17 | issue = 2 | pages = e4-7 | month = | year = | doi = 10.4158/EP10157.CR | PMID = 21134882 }}</ref> - may be found in specimen of a surgery done to exclude [[medullary thyroid carcinoma|MTC]] in the context of [[MEN 2A]].<ref name=pmid18976013>{{Cite journal | last1 = Etit | first1 = D. | last2 = Faquin | first2 = WC. | last3 = Gaz | first3 = R. | last4 = Randolph | first4 = G. | last5 = DeLellis | first5 = RA. | last6 = Pilch | first6 = BZ. | title = Histopathologic and clinical features of medullary microcarcinoma and C-cell hyperplasia in prophylactic thyroidectomies for medullary carcinoma: a study of 42 cases. | journal = Arch Pathol Lab Med | volume = 132 | issue = 11 | pages = 1767-73 | month = Nov | year = 2008 | doi = 10.1043/1543-2165-132.11.1767 | PMID = 18976013 }}</ref> | |||
*[[Multiple endocrine neoplasia type 2B]].<ref name=pmid20301434>{{Cite journal | last1 = Pagon | first1 = RA. | last2 = Adam | first2 = MP. | last3 = Ardinger | first3 = HH. | last4 = Wallace | first4 = SE. | last5 = Amemiya | first5 = A. | last6 = Bean | first6 = LJH. | last7 = Bird | first7 = TD. | last8 = Fong | first8 = CT. | last9 = Mefford | first9 = HC. | title = Multiple Endocrine Neoplasia Type 2 | journal = | volume = | issue = | pages = | month = | year = | doi = | PMID = 20301434 }}</ref> | |||
==Gross== | ==Gross== | ||
*Not visible. | *Not visible on gross. | ||
Location:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Thyroid_11protocol.pdf]. Accessed on: 7 April 2012.</ref> | |||
*Mid portion of lobe to upper third of lobe. | |||
**Not at the poles. | |||
**Not in the isthmus. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Definitions vary.<ref>Raphael S. 17 January 2011.</ref> | *Definitions vary.<ref>Raphael S. 17 January 2011.</ref> | ||
**One definition - either of the following:<ref name=pmid19726541>{{cite journal |author=Machens A, Hoffmann F, Sekulla C, Dralle H |title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer |journal=Endocr. Relat. Cancer |volume=16 |issue=4 |pages=1291–8 |year=2009 |month=December |pmid=19726541 |doi=10.1677/ERC-09-0136 |url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref> | **One definition - either of the following:<ref name=pmid19726541>{{cite journal |author=Machens A, Hoffmann F, Sekulla C, Dralle H |title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer |journal=Endocr. Relat. Cancer |volume=16 |issue=4 |pages=1291–8 |year=2009 |month=December |pmid=19726541 |doi=10.1677/ERC-09-0136 |url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref> | ||
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==IHC== | ==IHC== | ||
*Chromogranin A +ve. | *Chromogranin A +ve. | ||
*CEA +ve. | *[[CEA]] +ve. | ||
*Synaptophysin +ve. | *Synaptophysin +ve. | ||