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Lymphoepithelioma-like carcinoma of the urinary bladder (view source)
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'''Lymphoepithelioma-like carcinoma of the urinary bladder''' is a rare variant of [[urothelial carcinoma]].<ref name=pmid19494856>{{Cite journal | last1 = Amin | first1 = MB. | title = Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications. | journal = Mod Pathol | volume = 22 Suppl 2 | issue = | pages = S96-S118 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.26 | PMID = 19494856 }}</ref> | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Urinary bladder LELC -- very high mag.jpg | |||
| Width = | |||
| Caption = Urinary bladder lymphoepithelioma-like carcinoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate | |||
| Subtypes = (subtype of [[urothelial carcinoma]]) | |||
| LMDDx = [[lymphoma]], [[urothelial carcinoma]] and inflammation, metastatic [[lymphoepithelioma-like carcinoma]] | |||
| Stains = | |||
| IHC = [[CK34betaE12]] +ve, p63 +ve/-ve, [[CK7]] +ve/-ve, [[CK20]] -ve, CD30 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[urinary bladder]] - see ''[[urothelium]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = favourable on limited data | |||
| Other = not associated with [[EBV]] | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Lymphoepithelioma-like carcinoma of the urinary bladder''', also '''urinary bladder lymphoepithelioma-like carcinoma''' (abbreviated '''UBLELC'''), is a rare variant of [[urothelial carcinoma]].<ref name=pmid19494856>{{Cite journal | last1 = Amin | first1 = MB. | title = Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications. | journal = Mod Pathol | volume = 22 Suppl 2 | issue = | pages = S96-S118 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.26 | PMID = 19494856 }}</ref> | |||
==General== | ==General== | ||
*Rare. | |||
*Not associated with [[EBV]].<ref name=pmid21383609>{{Cite journal | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref> | *Not associated with [[EBV]].<ref name=pmid21383609>{{Cite journal | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref> | ||
*Good prognosis on scant data<ref>{{Cite journal | last1 = Fujino | first1 = T. | last2 = Kubota | first2 = M. | last3 = Nishiyama | first3 = R. | last4 = Kanno | first4 = T. | last5 = Okada | first5 = T. | last6 = Higashi | first6 = Y. | last7 = Yamada | first7 = H. | last8 = Okamoto | first8 = E. | title = [A case of lymphoepithelioma-like carcinoma of the bladder]. | journal = Hinyokika Kiyo | volume = 60 | issue = 10 | pages = 507-11 | month = Oct | year = 2014 | doi = | PMID = 25391783 }}</ref> - possibly poor if metastatic. | |||
==Microscopic== | ==Microscopic== | ||
: | Features: | ||
*Clusters of (cohesive) squamoid cells with: | |||
**Abundant dense cytoplasm. | |||
**Central nuclei +/- small/indistinct nucleoli. | |||
*Prominent lymphoid infiltrate - '''key feature'''. | |||
*+/-[[Urothelial carcinoma in situ]]. | |||
Note: | |||
*Peritumoural lymphoid aggregates are typical.<ref name=pmid19847088>{{Cite journal | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month = | year = | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }}</ref> | |||
DDx: | |||
*[[Lymphoma]]. | |||
*[[Urothelial carcinoma]] and inflammation. | |||
*Metastatic [[lymphoepithelioma-like carcinoma]]. | |||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Urinary bladder LELC -- low mag.jpg | UBLELC - low mag. (WC) | |||
Image: Urinary bladder LELC -- intermed mag.jpg | UBLELC - intermed. mag. (WC) | |||
Image: Urinary bladder LELC - a1t 2 -- intermed mag.jpg | UBLELC - intermed. mag. (WC) | |||
Image: Urinary bladder LELC -- high mag.jpg | UBLELC - high mag. (WC) | |||
Image: Urinary bladder LELC -- very high mag.jpg | UBLELC - very high mag. (WC) | |||
</gallery> | |||
www: | www: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0002/ LELC of the urinary bladder (nih.gov)].<ref name=pmid19847088>{{Cite journal | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month = | year = | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }} | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0002/ LELC of the urinary bladder - low mag. (nih.gov)].<ref name=pmid19847088>{{Cite journal | last1 = Singh | first1 = NG. | last2 = Mannan | first2 = AA. | last3 = Rifaat | first3 = AA. | last4 = Kahvic | first4 = M. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. | journal = Ann Saudi Med | volume = 29 | issue = 6 | pages = 478-81 | month = | year = | doi = 10.4103/0256-4947.57173 | PMID = 19847088 }}</ref> | ||
</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881438/figure/F0003/ LELC of the urinary bladder - high mag. (nih.gov)].<ref name=pmid19847088/> | ||
==IHC== | |||
Features:<ref name=pmid21383609/> | |||
*p53 +ve/-ve. (+ve in ~60% of cases). | |||
*CK34betaE12 +ve (+ve in ~75% of cases). | |||
*CK7 +ve/-ve (+ve in ~60% of cases). | |||
*p63 +ve/-ve (+ve in ~50% of cases). | |||
Others:<ref name=pmid21383609/> | |||
*CK20 -ve. | |||
*TTF-1 -ve. | |||
*CD30 -ve. | |||
==See also== | ==See also== | ||
*[[Urothelial carcinoma]]. | *[[Urothelial carcinoma]]. | ||
*[[Urinary bladder]]. | |||
*[[Lymphoepithelioma-like carcinoma]]. | |||
*[[Nasopharyngeal carcinoma]]. | |||
==References== | ==References== | ||