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Difference between revisions of "Pediatric-type diffuse high-grade glioma"
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Pediatric-type diffuse high-grade glioma (view source)
Revision as of 10:01, 5 April 2022
, 10:01, 5 April 2022+ Infant-type hemispheric glioma
Jensflorian (talk | contribs) (→Diffuse hemispheric glioma, H3 G34-mutant: +ref for IHC) |
Jensflorian (talk | contribs) (+ Infant-type hemispheric glioma) |
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=Diffuse midline glioma, H3 K27-altered= | |||
* High-grade astrocytic neoplasm associated with midline structures (thalamus, brain stem, spinal cord). | * High-grade astrocytic neoplasm associated with midline structures (thalamus, brain stem, spinal cord). | ||
* Mostly in children and adolescents. | * Mostly in children and adolescents. | ||
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</gallery> | </gallery> | ||
=Diffuse hemispheric glioma, H3 G34-mutant= | |||
* Diffusely infiltrating glioma in young adults and adolescents. | * Diffusely infiltrating glioma in young adults and adolescents. | ||
* WHO CNS grade 4 neoplasm. | * WHO CNS grade 4 neoplasm. | ||
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* H3F3A G43R or G34V mutation present. | * H3F3A G43R or G34V mutation present. | ||
==References | =Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype= | ||
=Infant-type hemispheric glioma= | |||
* Large astrocytic tumor. | |||
* Median age: 2 months. | |||
* Supratentorial. | |||
* May be present before birth. | |||
* Well demarcated. | |||
* Typically with ALK, ROS1 or MET fusions. | |||
* Distinct methylation tumor profile. | |||
* Outcome in infants with ALK fusions usu. somewhat better than in older children. | |||
* IHC: GFAP +/-ve, Olig2+ve | |||
=See also= | |||
*[[Pediatric-type diffuse low-grade glioma]]. | |||
=References= | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | [[Category:Neuropathology tumours]] | ||