Difference between revisions of "Microcystic adnexal carcinoma"
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*[http://www.dermaamin.com/site/images/histo-pic/m/microcystic-adnexal-carcinoma/microcystic-adnexal-carcinoma2.jpg Microcystic adnexal carcinoma (dermaamin.com)].<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref> | *[http://www.dermaamin.com/site/images/histo-pic/m/microcystic-adnexal-carcinoma/microcystic-adnexal-carcinoma2.jpg Microcystic adnexal carcinoma (dermaamin.com)].<ref name=dermaamin>URL: [http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html]. Accessed on: 16 September 2011.</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473631/figure/bjr-84-e114-g004/ MAC (nih.gov).<ref name=pmid21606063/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3473631/figure/bjr-84-e114-g004/ MAC (nih.gov)].<ref name=pmid21606063/> | ||
==IHC== | ==IHC== | ||
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**Positive in DTE. | **Positive in DTE. | ||
**Negative in sclerosing BCC. | **Negative in sclerosing BCC. | ||
*EMA +ve. | |||
**Negative in sclerosing BCC and desmoplastic trichoepithelioma. | |||
==See also== | ==See also== | ||
Latest revision as of 18:48, 3 March 2022
| Microcystic adnexal carcinoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | small basaloid cells - often forming small cystic spaces, usu. very bland cytology, fibrotic stroma |
| LM DDx | sclerosing basal cell carcinoma, desmoplastic trichoepithelioma, infiltrative squamous cell carcinoma |
| IHC | Ber-EP4 -ve, CD15 -ve |
| Site | skin - usually head and neck |
|
| |
| Clinical history | adults |
| Prevalence | very rare |
| Prognosis | good |
Microcystic adnexal carcinoma, also known as syringomatous carcinoma and sclerosing sweat duct carcinoma,[1] is rare malignant tumour of the skin that can have a deceptively bland appearance.
General
- Low-grade tumour.
- Adults.
- Very rare[2] ~ 150 cases in world literature in 2001.[3]
- Uncommonly metastases.[3]
Gross
Microscopic
Features:[5]
- Small basaloid cells - often forming small cystic spaces - key feature.
- Very bland cytology.
- Fibrotic stroma.
Notes:
- Margins typically positive - as MAC typically extends well beyond what is suspected clinically.[3]
DDx:
- Sclerosing basal cell carcinoma.
- Desmoplastic trichoepithelioma (DTE).[6]
- Infiltrative squamous cell carcinoma.
Images
www:
IHC
Features:[7]
- BerEP4 -ve.
- Positive in sclerosing basal cell carcinoma.
- CK15 -ve.
- Positive in DTE.
- Negative in sclerosing BCC.
- EMA +ve.
- Negative in sclerosing BCC and desmoplastic trichoepithelioma.
See also
References
- ↑ 1.0 1.1 URL: http://www.dermaamin.com/site/histopathology-of-the-skin/65-m/1926-microcystic-adnexal-carcinoma-.html. Accessed on: 16 September 2011.
- ↑ 2.0 2.1 Tawfik, AM.; Kreft, A.; Wagner, W.; Vogl, TJ. (Jun 2011). "MRI of a microcystic adnexal carcinoma of the skin mimicking a fibrous tumour: case report and literature review.". Br J Radiol 84 (1002): e114-7. doi:10.1259/bjr/44068180. PMID 21606063.
- ↑ 3.0 3.1 3.2 3.3 3.4 Snow, S.; Madjar, DD.; Hardy, S.; Bentz, M.; Lucarelli, MJ.; Bechard, R.; Aughenbaugh, W.; McFadden, T. et al. (Apr 2001). "Microcystic adnexal carcinoma: report of 13 cases and review of the literature.". Dermatol Surg 27 (4): 401-8. PMID 11298716.
- ↑ Gabillot-Carré, M.; Weill, F.; Mamelle, G.; Kolb, F.; Boitier, F.; Petrow, P.; Ortoli, JC.; Margulis, A. et al. (2006). "Microcystic adnexal carcinoma: report of seven cases including one with lung metastasis.". Dermatology 212 (3): 221-8. doi:10.1159/000091248. PMID 16549917.
- ↑ Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 412. ISBN 978-0443066542.
- ↑ Kirzhner, M.; Jakobiec, FA.; Borodic, G.. "Desmoplastic trichoepithelioma: report of a unique periocular case.". Ophthal Plast Reconstr Surg 28 (5): e121-3. doi:10.1097/IOP.0b013e318245535a. PMID 22366669.
- ↑ Sellheyer, K.; Nelson, P.; Kutzner, H.; Patel, RM. (Apr 2013). "The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers.". J Cutan Pathol 40 (4): 363-70. doi:10.1111/cup.12085. PMID 23398472.