Leydig cell tumour: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| (3 intermediate revisions by the same user not shown) | |||
| Line 7: | Line 7: | ||
| Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei | | Micro = cytoplasmic vacuolization, cytoplasm -- clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid -- eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei | ||
| Subtypes = benign (common), malignant (rare) | | Subtypes = benign (common), malignant (rare) | ||
| LMDDx = [[spermatocytic | | LMDDx = [[spermatocytic tumour]] (testis only), [[pregnancy luteoma]] (females only), [[Sertoli-Leydig cell tumour]], [[Leydig cell hyperplasia]] | ||
| Stains = | | Stains = | ||
| IHC = inhibin-alpha +ve, calretinin +ve, melan A +ve | | IHC = inhibin-alpha +ve, calretinin +ve, melan A +ve | ||
| Line 71: | Line 71: | ||
DDx: | DDx: | ||
*[[Spermatocytic | *[[Spermatocytic tumour]] (previously ''spermatocytic seminoma'') - may have eosinophilic cytoplasm. | ||
*[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies. | *[[Pregnancy luteoma]] - occurs during pregnancy, as the name implies. | ||
*Leydig cell hyperplasia. | *[[Leydig cell hyperplasia]]. | ||
*[[Granular cell tumour]].<ref name=pmid17284120/> | *[[Granular cell tumour]].<ref name=pmid17284120/> | ||
| Line 95: | Line 95: | ||
**Expressed in [[melanoma]], [[adrenal gland|adrenal tissue]], steroid-secreting tumours. | **Expressed in [[melanoma]], [[adrenal gland|adrenal tissue]], steroid-secreting tumours. | ||
*Vimentin +ve.<ref name=pmid17284120/> | *Vimentin +ve.<ref name=pmid17284120/> | ||
*[[SALL4]] -ve (10 of 10 cases).<ref name=pmid19390421>{{cite journal |authors=Cao D, Li J, Guo CC, Allan RW, Humphrey PA |title=SALL4 is a novel diagnostic marker for testicular germ cell tumors |journal=Am J Surg Pathol |volume=33 |issue=7 |pages=1065–77 |date=July 2009 |pmid=19390421 |doi=10.1097/PAS.0b013e3181a13eef |url=}}</ref> | |||
==Sign out== | ==Sign out== | ||
| Line 103: | Line 104: | ||
Comment: | Comment: | ||
The tumour consists of polygonal cells with abundant eosinophilic | The tumour consists of polygonal cells with abundant eosinophilic | ||
cytoplasm, round nuclei with prominent nucleoli. | cytoplasm, round nuclei with prominent nucleoli. | ||
Features suggestive of malignancy are absent. | |||
The tumour stains with calretinin, Melan A and inhibin. It is | The tumour stains with calretinin, Melan A and inhibin. It is | ||