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Difference between revisions of "Adenocarcinoma of the lung"
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Adenocarcinoma of the lung (view source)
Revision as of 21:54, 11 January 2022
, 21:54, 11 January 2022→Lepidic pattern on biopsy: tweak
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*[[Atypical adenomatous hyperplasia of the lung]] - spaced [[hobnail]] cells, mild-to-moderate nuclear atypia, small lesion (< 5 mm). | *[[Atypical adenomatous hyperplasia of the lung]] - spaced [[hobnail]] cells, mild-to-moderate nuclear atypia, small lesion (must be <5 mm). | ||
*Adenocarcinoma in situ. | *Adenocarcinoma in situ. | ||
*[[Papillary thyroid carcinoma|Papillary carcinoma of thyroid]]. | *[[Papillary thyroid carcinoma|Papillary carcinoma of thyroid]]. | ||
*[[Squamous cell carcinoma of the lung]]. | *[[Squamous cell carcinoma of the lung]]. | ||
*[[Small cell carcinoma of the lung]]. | *[[Small cell carcinoma of the lung]]. | ||
*[[Adenoid | *[[Adenoid cystic carcinoma]]. | ||
*[[Non-small cell lung carcinoma]] - diagnosis should be avoided if possible. | *[[Non-small cell lung carcinoma]] - diagnosis should be avoided if possible. | ||
*[[Malignant mesothelioma]]. | *[[Malignant mesothelioma]]. | ||
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***[[Invasive ductal carcinoma of the breast]]. | ***[[Invasive ductal carcinoma of the breast]]. | ||
***[[Invasive lobular carcinoma]]. | ***[[Invasive lobular carcinoma]]. | ||
***[[Bronchiolar metaplasia]]. | |||
**Other carcinomas. | **Other carcinomas. | ||
*Carcinomas of the bronchial glands, e.g. [[adenoid cystic carcinoma]]. | *Carcinomas of the bronchial glands, e.g. [[adenoid cystic carcinoma]]. | ||
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===Classification=== | ===Classification=== | ||
Classification based on extent:<ref name=pmid21252716>{{cite journal |author=Travis WD, Brambilla E, Noguchi M, ''et al.'' |title=International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma |journal=J Thorac Oncol |volume=6 |issue=2 |pages=244–85 |year=2011 |month=February |pmid=21252716 |doi=10.1097/JTO.0b013e318206a221 |url=}}</ref> | Classification based on extent:<ref name=pmid21252716>{{cite journal |author=Travis WD, Brambilla E, Noguchi M, ''et al.'' |title=International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma |journal=J Thorac Oncol |volume=6 |issue=2 |pages=244–85 |year=2011 |month=February |pmid=21252716 |doi=10.1097/JTO.0b013e318206a221 |url=}}</ref> | ||
#Adenocarcinoma in situ (AIS) - previously known as [[BAC]]. | #Adenocarcinoma in situ (AIS) - previously known as ''bronchioloalveolar carcinoma'' (abbreviated [[BAC]]). | ||
#*Subtypes: nonmucinous, mucinous, mixed mucinous/nonmucinous. | #*Subtypes: nonmucinous, mucinous, mixed mucinous/nonmucinous. | ||
#*Definition: lack of invasion into the stroma, vascular spaces and pleura. | #*Definition: lack of invasion into the stroma, vascular spaces and pleura. | ||
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The adenocarcinoma is positive for TTF-1 and napsin. EGFR/ALK testing was ordered. | The adenocarcinoma is positive for TTF-1 and napsin. EGFR/ALK testing was ordered. | ||
</pre> | </pre> | ||
====Lepidic pattern on biopsy==== | |||
Important note: lesion '''''must''''' be >=5 mm ''and'' <=30 mm. | |||
<pre> | |||
Lung, Left Upper Lobe, Core Biopsy: | |||
- ADENOCARCINOMA, lepidic pattern. | |||
Comment: | |||
The tumour is stains as follows: | |||
POSITIVE: TTF-1, napsin A, CK7. | |||
NEGATIVE: p40. | |||
The findings are in keeping with lepidic pattern adenocarcinoma; the differential diagnosis includes: (1) adenocarcinoma in situ, (2) minimally invasive adenocarcinoma, and (3) invasive adenocarcinoma. | |||
Lung biomarkers (EGFR, ALK, PDL1, ROS1) have been ordered. | |||
</pre> | |||
=====Mucinous adenocarcinoma with noncontributory stains===== | =====Mucinous adenocarcinoma with noncontributory stains===== | ||
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*[[Metastasis]]. | *[[Metastasis]]. | ||
*[[Lung carcinoma with ALK rearrangement]]. | *[[Lung carcinoma with ALK rearrangement]]. | ||
*[[SMARCA4-deficient adenocarcinoma of the lung]]. | |||
==References== | ==References== | ||