48,849
edits
Difference between revisions of "Small cell carcinoma of the lung"
Jump to navigation
Jump to search
Small cell carcinoma of the lung (view source)
Revision as of 21:53, 10 December 2021
, 21:53, 10 December 2021→Possible LCNEC: tweak
(→IHC) |
(→Possible LCNEC: tweak) |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 8: | Line 8: | ||
| Subtypes = large cell neuroendocrine carcinoma (LCNEC) | | Subtypes = large cell neuroendocrine carcinoma (LCNEC) | ||
| LMDDx = poorly differentiated [[adenocarcinoma of the lung]], [[atypical carcinoid]], [[lung carcinoid]], metastatic [[small cell carcinoma]], [[lymphoma]], other [[small round blue cell tumours]] | | LMDDx = poorly differentiated [[adenocarcinoma of the lung]], [[atypical carcinoid]], [[lung carcinoid]], metastatic [[small cell carcinoma]], [[lymphoma]], other [[small round blue cell tumours]] | ||
| Stains = chromogranin +ve, synaptophysin +ve, CD56 +ve, NSE +ve, TTF-1 +ve | | Stains = | ||
| IHC = chromogranin +ve, synaptophysin +ve, CD56 +ve, NSE +ve, TTF-1 +ve, Ki-67 (>50%) | |||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 104: | Line 104: | ||
*CK7 -ve.<ref name=pmid10874668>{{Cite journal | last1 = Gyure | first1 = KA. | last2 = Morrison | first2 = AL. | title = Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. | journal = Mod Pathol | volume = 13 | issue = 6 | pages = 638-43 | month = Jun | year = 2000 | doi = 10.1038/modpathol.3880111 | PMID = 10874668 }}</ref> | *CK7 -ve.<ref name=pmid10874668>{{Cite journal | last1 = Gyure | first1 = KA. | last2 = Morrison | first2 = AL. | title = Cytokeratin 7 and 20 expression in choroid plexus tumors: utility in differentiating these neoplasms from metastatic carcinomas. | journal = Mod Pathol | volume = 13 | issue = 6 | pages = 638-43 | month = Jun | year = 2000 | doi = 10.1038/modpathol.3880111 | PMID = 10874668 }}</ref> | ||
*[[CK20]] -ve.<ref name=pmid10874668/> | *[[CK20]] -ve.<ref name=pmid10874668/> | ||
*Ki-67 ~80% | *Ki-67 ~80% (>50% proposed as criteria for ''large cell neuroendocrine carcinoma''<ref name=pmid25318848>{{Cite journal | last1 = Liu | first1 = SZ. | last2 = Staats | first2 = PN. | last3 = Goicochea | first3 = L. | last4 = Alexiev | first4 = BA. | last5 = Shah | first5 = N. | last6 = Dixon | first6 = R. | last7 = Burke | first7 = AP. | title = Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung. | journal = Diagn Pathol | volume = 9 | issue = | pages = 174 | month = | year = 2014 | doi = 10.1186/s13000-014-0174-z | PMID = 25318848 }}</ref>). | ||
**Useful for separating from ''atypical carcinoid'' and ''typical carcinoid''. | **Useful for separating from ''atypical carcinoid'' and ''typical carcinoid''. | ||
| Line 111: | Line 111: | ||
==Sign out== | ==Sign out== | ||
===Biopsy=== | |||
<pre> | <pre> | ||
Lung, Left Lower Lobe, Core Biopsy: | Lung, Left Lower Lobe, Core Biopsy: | ||
| Line 116: | Line 117: | ||
</pre> | </pre> | ||
===Block letters=== | ====Possible LCNEC==== | ||
<pre> | |||
Lung, Left Lower Lobe, Core Biopsy: | |||
- NON–SMALL CELL CARCINOMA WITH NEUROENDOCRINE (NE) MORPHOLOGY AND POSITIVE NE MARKERS, POSSIBLE LARGE CELL NEUROENDOCRINE CARCINOMA (LCNEC). | |||
</pre> | |||
Note: | |||
*The above is the wording recommended by 2011 ATS/ERS/IASLC panel.<ref>{{cite journal |authors=Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger K, Yatabe Y, Ishikawa Y, Wistuba I, Flieder DB, Franklin W, Gazdar A, Hasleton PS, Henderson DW, Kerr KM, Petersen I, Roggli V, Thunnissen E, Tsao M |title=Diagnosis of lung cancer in small biopsies and cytology: implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification |journal=Arch Pathol Lab Med |volume=137 |issue=5 |pages=668–84 |date=May 2013 |pmid=22970842 |pmc=4509741 |doi=10.5858/arpa.2012-0263-RA |url=}}</ref> | |||
====Block letters==== | |||
<pre> | <pre> | ||
LOWER LOBE OF LUNG, LEFT, CORE BIOPSY: | LOWER LOBE OF LUNG, LEFT, CORE BIOPSY: | ||