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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Phyllodes_tumour_-_very_low_mag.jpg | |||
| Width = | |||
| Caption = Phyllodes tumour. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = either (1) or (2): (1) large slit-like spaces, (2) cellular stroma - may be myxoid; +/-infiltrative border, +/-mitoses, +/-nuclear atypia, +/-"stromal overgrowth" ~ stroma fills microscopic field (see ''microscopic'' section) | |||
| Subtypes = benign, borderline, malignant | |||
| LMDDx = [[fibroadenoma]], [[metaplastic breast carcinoma]], primary breast sarcoma, other [[sarcoma]]s | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = mass with clefts - leaf-like structures | |||
| Grossing = | |||
| Site = [[breast]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = mass lesion | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usually benign, may be malignant | |||
| Other = | |||
| ClinDDx = other breast tumours - often [[fibroadenoma]] | |||
| Tx = wide excision | |||
}} | |||
'''Phyllodes tumour''' is a tumour of the intralobular breast stroma. It may be benign or [[malignant]]. | '''Phyllodes tumour''' is a tumour of the intralobular breast stroma. It may be benign or [[malignant]]. | ||
It was previously called '''cystosarcoma phyllodes'''. | It was previously called '''cystosarcoma phyllodes'''. It is a type of [[fibroepithelial tumours of the breast|fibroepithelial tumour]]. | ||
==General== | ==General== | ||
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*+/-Mitoses. | *+/-Mitoses. | ||
*+/-Nuclear atypia. | *+/-Nuclear atypia. | ||
*+/-"Stromal overgrowth" ~ stroma fills microscopic field. | *+/-"Stromal overgrowth" ~ stroma fills microscopic field (see below). | ||
Notes: | Notes: | ||
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Image:Phyllodes_tumour_-_very_low_mag.jpg | Phyllodes tumour - very low mag. (WC/Nephron) | Image:Phyllodes_tumour_-_very_low_mag.jpg | Phyllodes tumour - very low mag. (WC/Nephron) | ||
Image:Phyllodes_tumour_-_low_mag.jpg | Phyllodes tumour - low mag. (WC/Nephron) | Image:Phyllodes_tumour_-_low_mag.jpg | Phyllodes tumour - low mag. (WC/Nephron) | ||
Image:Malignant phyllodes tumour.jpg |Malignant phyllodes tumour - low mag (WC) | |||
Image:Malignant phyllodes tumour high magnification.jpg |Malignant phyllodes tumour - high mag (WC) | |||
</gallery> | </gallery> | ||
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* † Stromal overgrowth = epithelial elements absent in one low power field (LPF), defined as x40;<ref name=pmid17932112>{{cite journal |author=Taira N, Takabatake D, Aogi K, ''et al'' |title=Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin |journal=Jpn. J. Clin. Oncol. |volume=37 |issue=10 |pages=730-6 |year=2007 |month=October |pmid=17932112 |doi=10.1093/jjco/hym099 |url=http://jjco.oxfordjournals.org/cgi/reprint/37/10/730}}</ref> ''LPF'' is not adequately defined - see [[LPFitis]]. | * † Stromal overgrowth = epithelial elements absent in one low power field (LPF), defined as x40;<ref name=pmid17932112>{{cite journal |author=Taira N, Takabatake D, Aogi K, ''et al'' |title=Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin |journal=Jpn. J. Clin. Oncol. |volume=37 |issue=10 |pages=730-6 |year=2007 |month=October |pmid=17932112 |doi=10.1093/jjco/hym099 |url=http://jjco.oxfordjournals.org/cgi/reprint/37/10/730}}</ref> ''LPF'' is not adequately defined - see [[LPFitis]]. | ||
* ‡ ''HPF'' is not adequately defined - see [[HPFitis]]. | * ‡ ''HPF'' is not adequately defined - see [[HPFitis]]. | ||
==Sign out== | |||
===Benign=== | |||
<pre> | |||
Right Breast Mass, Excision: | |||
- Benign phyllodes tumour. | |||
- NEGATIVE for malignancy. | |||
</pre> | |||
====Micro==== | |||
The sections show a well-circumscribed mass with a leaf-like architecture. There is no stromal overgrowth or atypia. Proliferative activity is not readily apparent. | |||
==See also== | ==See also== |
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