Sarcoidosis: Difference between revisions
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| IHC = | | IHC = | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = PCR for [[tuberculosis]] -ve | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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*Carcinomatosis - interstitial pattern.<ref>URL: [http://www.radiologyassistant.nl/en/46b480a6e4bdc http://www.radiologyassistant.nl/en/46b480a6e4bdc]. Accessed on: 23 May 2010.</ref> | *Carcinomatosis - interstitial pattern.<ref>URL: [http://www.radiologyassistant.nl/en/46b480a6e4bdc http://www.radiologyassistant.nl/en/46b480a6e4bdc]. Accessed on: 23 May 2010.</ref> | ||
*Lymphoma - bilateral lymphadenopathy +/- mediastinal lymphadenopathy.<ref name=pmid23207258>{{Cite journal | last1 = Boujaoude | first1 = Z. | last2 = Dahdel | first2 = M. | last3 = Pratter | first3 = M. | last4 = Kass | first4 = J. | title = Endobronchial ultrasound with transbronchial needle aspiration in the diagnosis of bilateral hilar and mediastinal lymphadenopathy. | journal = J Bronchology Interv Pulmonol | volume = 19 | issue = 1 | pages = 19-23 | month = Jan | year = 2012 | doi = 10.1097/LBR.0b013e3182442b89 | PMID = 23207258 }}</ref> | *Lymphoma - bilateral lymphadenopathy +/- mediastinal lymphadenopathy.<ref name=pmid23207258>{{Cite journal | last1 = Boujaoude | first1 = Z. | last2 = Dahdel | first2 = M. | last3 = Pratter | first3 = M. | last4 = Kass | first4 = J. | title = Endobronchial ultrasound with transbronchial needle aspiration in the diagnosis of bilateral hilar and mediastinal lymphadenopathy. | journal = J Bronchology Interv Pulmonol | volume = 19 | issue = 1 | pages = 19-23 | month = Jan | year = 2012 | doi = 10.1097/LBR.0b013e3182442b89 | PMID = 23207258 }}</ref> | ||
<gallery> | |||
File:Sarcoidosis - Bilateral hilar lymphadenoathy (6076995153).jpg | Markedly enlarged bilaterally hilar lymph nodes in stage 1 sarcoidosis (WC/Yale Rosen) | |||
File:Sarcoidosis - Fibrosis (6076822244).jpg | Fibrosis (WC/Yale Rosen) | |||
</gallery> | |||
==Microscopic== | ==Microscopic== | ||
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<gallery> | <gallery> | ||
Image:Asteroid_body_intermed_mag.jpg | Sarcoidosis - lung. (WC) | Image:Asteroid_body_intermed_mag.jpg | Sarcoidosis - lung. (WC) | ||
Image:Asteroid_body_very_high_mag.jpg | Granulomata in sarcoidosis with asteroid bodies. (WC) | Image:Asteroid_body_very_high_mag.jpg | Granulomata in sarcoidosis with [[asteroid bodies]]. (WC) | ||
File:Sarcoidosis - Schaumann body (6151514639).jpg | [[Schaumann body]] in sarcoidosis. (WC/Yale Rosen) | |||
File:Sarcoidosis - Fibrosis of granulomas (6148634442).jpg | Fibrosis in sarcoid granulomas. (WC/Yale Rosen) | |||
File:Sarkoidosis muscle.jpg | Muscle involvement in sarcoidosis. (WC/jensflorian) | |||
File:Sarcoidosis_histology_skin_involvement.jpg | Skin involvement in sarcoidosis. (WC/jensflorian) | |||
</gallery> | </gallery> | ||
www | ====Case==== | ||
<gallery> | |||
Image: Sarcoidosis - lung FNA -- very low mag.jpg | Sarcoidosis lung - very low mag. (WC) | |||
Image: Sarcoidosis - lung FNA -- low mag.jpg | Sarcoidosis lung - low mag. (WC) | |||
Image: Sarcoidosis - lung FNA -- intermed mag.jpg | Sarcoidosis lung - intermed. mag. (WC) | |||
Image: Sarcoidosis - lung FNA -- high mag.jpg | Sarcoidosis lung - high mag. (WC) | |||
Image: Sarcoidosis - lung FNA -- very high mag.jpg | Sarcoidosis lung - very high mag. (WC) | |||
</gallery> | |||
====www==== | |||
*[http://path.upmc.edu/cases/case412.html Sarcoidosis - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case412.html Sarcoidosis - several images (upmc.edu)]. | ||
*[http://path.upmc.edu/cases/case517.html Neurosarcoidosis - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case517.html Neurosarcoidosis - several images (upmc.edu)]. | ||
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Note: | Note: | ||
*Must be done to exclude infection. | *Must be done to exclude infection. | ||
==Molecular== | |||
*PCR for Tuberculosis -ve. | |||
==Sign out== | ==Sign out== | ||
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Sarcoidosis is favoured based on the morphology of the granulomas and the | Sarcoidosis is favoured based on the morphology of the granulomas and the | ||
lack of microorganisms with special stains (ZN, PASF, GMS). | lack of microorganisms with special stains (ZN, PASF, GMS). | ||
A serum ACE level should be considered, if not already done. | |||
Clinical and radiologic correlation is required. | Clinical and radiologic correlation is required. | ||
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*[[Medical lung diseases]]. | *[[Medical lung diseases]]. | ||
*[[Cardiac sarcoidosis]]. | *[[Cardiac sarcoidosis]]. | ||
*[[Melkersson-Rosenthal syndrome]]. | |||
==References== | ==References== | ||