Sarcoidosis: Difference between revisions

Jump to navigation Jump to search
← Older edit
Michael (talk | contribs)
49,349 edits
Michael (talk | contribs)
49,349 edits
 
(8 intermediate revisions by 2 users not shown)
Line 1: Line 1:
{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      = Sarcoidosis (1) lymph node biopsy.jpg
| Image      = Sarcoidosis (1) lymph node biopsy.jpg  
| Width      =
| Width      =
| Caption    = Sarcoidosis-like granulomas in a lymph node. [[H&E stain]].
| Caption    = Sarcoidosis-like granulomas in a lymph node. [[H&E stain]].
Line 10: Line 10:
| IHC        =  
| IHC        =  
| EM        =
| EM        =
| Molecular  =  
| Molecular  = PCR for [[tuberculosis]] -ve
| IF        =
| IF        =
| Gross      =  
| Gross      =  
Line 49: Line 49:
*Carcinomatosis - interstitial pattern.<ref>URL: [http://www.radiologyassistant.nl/en/46b480a6e4bdc http://www.radiologyassistant.nl/en/46b480a6e4bdc]. Accessed on: 23 May 2010.</ref>
*Carcinomatosis - interstitial pattern.<ref>URL: [http://www.radiologyassistant.nl/en/46b480a6e4bdc http://www.radiologyassistant.nl/en/46b480a6e4bdc]. Accessed on: 23 May 2010.</ref>
*Lymphoma - bilateral lymphadenopathy +/- mediastinal lymphadenopathy.<ref name=pmid23207258>{{Cite journal  | last1 = Boujaoude | first1 = Z. | last2 = Dahdel | first2 = M. | last3 = Pratter | first3 = M. | last4 = Kass | first4 = J. | title = Endobronchial ultrasound with transbronchial needle aspiration in the diagnosis of bilateral hilar and mediastinal lymphadenopathy. | journal = J Bronchology Interv Pulmonol | volume = 19 | issue = 1 | pages = 19-23 | month = Jan | year = 2012 | doi = 10.1097/LBR.0b013e3182442b89 | PMID = 23207258 }}</ref>
*Lymphoma - bilateral lymphadenopathy +/- mediastinal lymphadenopathy.<ref name=pmid23207258>{{Cite journal  | last1 = Boujaoude | first1 = Z. | last2 = Dahdel | first2 = M. | last3 = Pratter | first3 = M. | last4 = Kass | first4 = J. | title = Endobronchial ultrasound with transbronchial needle aspiration in the diagnosis of bilateral hilar and mediastinal lymphadenopathy. | journal = J Bronchology Interv Pulmonol | volume = 19 | issue = 1 | pages = 19-23 | month = Jan | year = 2012 | doi = 10.1097/LBR.0b013e3182442b89 | PMID = 23207258 }}</ref>
<gallery>
File:Sarcoidosis - Bilateral hilar lymphadenoathy (6076995153).jpg | Markedly enlarged bilaterally hilar lymph nodes in stage 1 sarcoidosis (WC/Yale Rosen)
File:Sarcoidosis - Fibrosis (6076822244).jpg | Fibrosis (WC/Yale Rosen)
</gallery>


==Microscopic==
==Microscopic==
Line 74: Line 79:
**All testicular tumours<ref name=pmid18496978>{{Cite journal  | last1 = Paparel | first1 = P. | last2 = Devonec | first2 = M. | last3 = Perrin | first3 = P. | last4 = Ruffion | first4 = A. | last5 = Decaussin-Petrucci | first5 = M. | last6 = Akin | first6 = O. | last7 = Sheinfeld | first7 = J. | last8 = Guillonneau | first8 = B. | title = Association between sarcoidosis and testicular carcinoma: a diagnostic pitfall. | journal = Sarcoidosis Vasc Diffuse Lung Dis | volume = 24 | issue = 2 | pages = 95-101 | month = Sep | year = 2007 | doi =  | PMID = 18496978 }}</ref> - esp. [[seminoma]].<ref name=pmid17240627>{{Cite journal  | last1 = Jankilevich | first1 = G. | last2 = Mendizabal | first2 = J. | last3 = Massa | first3 = MA. | last4 = Pedernera | first4 = A. | last5 = Galmes | first5 = M. | last6 = Spizzamiglio | first6 = N. | title = [Mediastinal sarcoidal reaction in follow up for seminoma]. | journal = Medicina (B Aires) | volume = 66 | issue = 6 | pages = 552-4 | month =  | year = 2006 | doi =  | PMID = 17240627 }}</ref>
**All testicular tumours<ref name=pmid18496978>{{Cite journal  | last1 = Paparel | first1 = P. | last2 = Devonec | first2 = M. | last3 = Perrin | first3 = P. | last4 = Ruffion | first4 = A. | last5 = Decaussin-Petrucci | first5 = M. | last6 = Akin | first6 = O. | last7 = Sheinfeld | first7 = J. | last8 = Guillonneau | first8 = B. | title = Association between sarcoidosis and testicular carcinoma: a diagnostic pitfall. | journal = Sarcoidosis Vasc Diffuse Lung Dis | volume = 24 | issue = 2 | pages = 95-101 | month = Sep | year = 2007 | doi =  | PMID = 18496978 }}</ref> - esp. [[seminoma]].<ref name=pmid17240627>{{Cite journal  | last1 = Jankilevich | first1 = G. | last2 = Mendizabal | first2 = J. | last3 = Massa | first3 = MA. | last4 = Pedernera | first4 = A. | last5 = Galmes | first5 = M. | last6 = Spizzamiglio | first6 = N. | title = [Mediastinal sarcoidal reaction in follow up for seminoma]. | journal = Medicina (B Aires) | volume = 66 | issue = 6 | pages = 552-4 | month =  | year = 2006 | doi =  | PMID = 17240627 }}</ref>
**[[Lung adenocarcinoma]].<ref name=pmid22499972>{{Cite journal  | last1 = Tao | first1 = H. | last2 = Yamamoto | first2 = H. | last3 = Matsuda | first3 = E. | last4 = Sano | first4 = F. | last5 = Okabe | first5 = K. | last6 = Sugi | first6 = K. | title = Severe bronchoconstriction due to sarcoid-like reaction to lung cancer. | journal = Asian Cardiovasc Thorac Ann | volume = 20 | issue = 2 | pages = 199-201 | month = Apr | year = 2012 | doi = 10.1177/0218492311431493 | PMID = 22499972 }}</ref>
**[[Lung adenocarcinoma]].<ref name=pmid22499972>{{Cite journal  | last1 = Tao | first1 = H. | last2 = Yamamoto | first2 = H. | last3 = Matsuda | first3 = E. | last4 = Sano | first4 = F. | last5 = Okabe | first5 = K. | last6 = Sugi | first6 = K. | title = Severe bronchoconstriction due to sarcoid-like reaction to lung cancer. | journal = Asian Cardiovasc Thorac Ann | volume = 20 | issue = 2 | pages = 199-201 | month = Apr | year = 2012 | doi = 10.1177/0218492311431493 | PMID = 22499972 }}</ref>


===Images===
===Images===
<gallery>
<gallery>
Image:Asteroid_body_intermed_mag.jpg | Sarcoidosis - lung. (WC)
Image:Asteroid_body_intermed_mag.jpg | Sarcoidosis - lung. (WC)
Image:Asteroid_body_very_high_mag.jpg | Granulomata in sarcoidosis with asteroid bodies. (WC)
Image:Asteroid_body_very_high_mag.jpg | Granulomata in sarcoidosis with [[asteroid bodies]]. (WC)
File:Sarcoidosis - Schaumann body (6151514639).jpg | [[Schaumann body]] in sarcoidosis. (WC/Yale Rosen)
File:Sarcoidosis - Fibrosis of granulomas (6148634442).jpg | Fibrosis in sarcoid granulomas. (WC/Yale Rosen)
File:Sarkoidosis muscle.jpg | Muscle involvement in sarcoidosis. (WC/jensflorian)
File:Sarcoidosis_histology_skin_involvement.jpg | Skin involvement in sarcoidosis. (WC/jensflorian)
</gallery>
====Case====
<gallery>
Image: Sarcoidosis - lung FNA -- very low mag.jpg | Sarcoidosis lung - very low mag. (WC)
Image: Sarcoidosis - lung FNA -- low mag.jpg | Sarcoidosis lung - low mag. (WC)
Image: Sarcoidosis - lung FNA -- intermed mag.jpg | Sarcoidosis lung - intermed. mag. (WC)
Image: Sarcoidosis - lung FNA -- high mag.jpg | Sarcoidosis lung - high mag. (WC)
Image: Sarcoidosis - lung FNA -- very high mag.jpg | Sarcoidosis lung - very high mag. (WC)
</gallery>
</gallery>
www:
====www====
*[http://path.upmc.edu/cases/case412.html Sarcoidosis - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case412.html Sarcoidosis - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case517.html Neurosarcoidosis - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case517.html Neurosarcoidosis - several images (upmc.edu)].
Line 92: Line 108:
Note:
Note:
*Must be done to exclude infection.
*Must be done to exclude infection.
==Molecular==
*PCR for Tuberculosis -ve.


==Sign out==
==Sign out==
Line 115: Line 134:
Sarcoidosis is favoured based on the morphology of the granulomas and the  
Sarcoidosis is favoured based on the morphology of the granulomas and the  
lack of microorganisms with special stains (ZN, PASF, GMS).
lack of microorganisms with special stains (ZN, PASF, GMS).
A serum ACE level should be considered, if not already done.


Clinical and radiologic correlation is required.
Clinical and radiologic correlation is required.
Line 122: Line 143:
*[[Medical lung diseases]].
*[[Medical lung diseases]].
*[[Cardiac sarcoidosis]].
*[[Cardiac sarcoidosis]].
*[[Melkersson-Rosenthal syndrome]].


==References==
==References==
Retrieved from "https://librepathology.org/wiki/Sarcoidosis"