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Difference between revisions of "Nasopharyngeal carcinoma"
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| Caption = Nasopharyngeal carcinoma. [[H&E stain]]. | | Caption = Nasopharyngeal carcinoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = nasopharyngeal-type undifferentiated carcinoma, non-keratining nasopharyngeal carcinoma undifferentiated type | ||
| Micro = Cohesive typical (squamoid) cells (abundant dense eosinophilic cytoplasm, central nuclei +/- small/indistinct nucleoli), prominent lymphoid component | | Micro = Cohesive typical (squamoid) cells (abundant dense eosinophilic cytoplasm, central nuclei +/- small/indistinct nucleoli), prominent lymphoid component | ||
| Subtypes = keratinizing SCC; nonkeratinizing carcinoma, differentiated; nonkeratinizing carcinoma, undifferentiated; basaloid SCC | | Subtypes = keratinizing SCC; nonkeratinizing carcinoma, differentiated; nonkeratinizing carcinoma, undifferentiated; basaloid SCC | ||
| LMDDx = [[HPV-associated head and neck squamous cell carcinoma]], [[squamous cell carcinoma of the head and neck]] | | LMDDx = [[HPV-associated head and neck squamous cell carcinoma]], [[squamous cell carcinoma of the head and neck]], [[sinonasal undifferentiated carcinoma]] (SNUC) | ||
| Stains = | | Stains = | ||
| IHC = p16 -ve, LMP-1 -ve/+ve | | IHC = p16 -ve, LMP-1 -ve/+ve | ||
| EM = | | EM = | ||
| Molecular = EBER +ve | | Molecular = [[EBER]] +ve | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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*[[HPV-associated head and neck squamous cell carcinoma]]. | *[[HPV-associated head and neck squamous cell carcinoma]]. | ||
*[[Squamous cell carcinoma of the head and neck]]. | *[[Squamous cell carcinoma of the head and neck]]. | ||
*[[Sinonasal undifferentiated carcinoma]] (SNUC). | |||
===Images=== | ===Images=== | ||
====Case 1==== | ====Case 1==== | ||
<gallery> | <gallery> | ||
Image: Nasopharyngeal carcinoma -- extremely low mag.jpg | | Image: Nasopharyngeal carcinoma -- extremely low mag.jpg | NPC - very low mag. (WC) | ||
Image: Nasopharyngeal carcinoma -- very low mag.jpg | | Image: Nasopharyngeal carcinoma -- very low mag.jpg | NPC - very low mag. (WC) | ||
Image: Nasopharyngeal carcinoma -- low mag.jpg | | Image: Nasopharyngeal carcinoma -- low mag.jpg | NPC - low mag. (WC) | ||
Image: Nasopharyngeal carcinoma -- intermed mag.jpg | | Image: Nasopharyngeal carcinoma -- intermed mag.jpg | NPC - intermed. mag. (WC) | ||
Image: Nasopharyngeal carcinoma -- high mag.jpg | | Image: Nasopharyngeal carcinoma -- high mag.jpg | NPC - high mag. (WC) | ||
Image: Nasopharyngeal carcinoma - alt -- high mag.jpg | | Image: Nasopharyngeal carcinoma - alt -- high mag.jpg | NPC - high mag. (WC) | ||
Image: Nasopharyngeal carcinoma -- very high mag.jpg | | Image: Nasopharyngeal carcinoma -- very high mag.jpg | NPC - very high mag. (WC) | ||
</gallery> | </gallery> | ||
====Case 2==== | ====Case 2==== | ||
<gallery> | <gallery> | ||
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==Molecular== | ==Molecular== | ||
*EBER +ve.<ref name=pmid11913680/> | *[[EBER]] +ve.<ref name=pmid11913680/> | ||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: Nasopharyngeal carcinoma - EBER -- very low mag.jpg | | Image: Nasopharyngeal carcinoma - EBER -- very low mag.jpg | NPC - EBER - very low mag. (WC) | ||
Image: Nasopharyngeal carcinoma - EBER -- low mag.jpg | | Image: Nasopharyngeal carcinoma - EBER -- low mag.jpg | NPC - EBER - low mag. (WC) | ||
Image: Nasopharyngeal carcinoma - EBER -- high mag.jpg | | Image: Nasopharyngeal carcinoma - EBER -- high mag.jpg | NPC - EBER - high mag. (WC) | ||
</gallery> | </gallery> | ||