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Difference between revisions of "Plasma cell"
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(→See also: +IgG4 disease) |
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[[Image:Plasmacell.jpg|thumb|right|A plasma cell.]] | |||
The '''plasma cell''' is white blood cell that produces antibodies. | The '''plasma cell''' is white blood cell that produces antibodies. | ||
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***Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells. | ***Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells. | ||
Images: | Note: | ||
*Multinucleation is not a worisome feature.{{fact}} | |||
===Images=== | |||
<gallery> | |||
Image: Multinucleated plasma cell -- high mag.jpg | Plasma cells - high mag. | |||
Image: Multinucleated plasma cell -- very high mag.jpg | Plasma cells - very high mag. | |||
Image: Multinucleated plasma cell -- extremely high mag.jpg | Plasma cells - extremely high mag. | |||
Image: Chronic_gastritis_--_very_high_mag.jpg | Plasma cells in [[chronic gastritis]] - very high mag. | |||
</gallery> | |||
<gallery> | |||
Image:Plasmacytoma_ultramini1.jpg | Plasma cells in a plasmacytoma. (WC) | |||
</gallery> | |||
==Neoplasia== | ==Neoplasia== | ||
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==IHC== | ==IHC== | ||
*CD38 +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref> | *CD38 +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref> | ||
*CD138 +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref> | *[[CD138]] +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref> | ||
Others: | Others: | ||
*CD19 -ve. | *CD19 -ve. | ||
*CD20 -ve | *CD20 -ve | ||
*CD56 -ve. | *[[CD56]] -ve. | ||
==Lesions where plasma cells are important== | ==Lesions where plasma cells are important== | ||
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Inflammatory conditions: | Inflammatory conditions: | ||
*[[Inflammatory bowel disease | *[[Inflammatory bowel disease]] - esp. at crypt base. | ||
*[[Primary biliary | *[[Primary biliary cholangitis]]. | ||
*[[Chronic gastritis]]. | *[[Chronic gastritis]]. | ||
*[[Plasma cell balanitis]] (Zoon balanitis). | |||
*[[Plasma cell vulvitis]] (Zoon vulvitis). | |||
*[[Plasma cell deciduitis]] (chronic deciduitis). | |||
Infectious: | Infectious: | ||
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*[[Plasma cell neoplasms]]. | *[[Plasma cell neoplasms]]. | ||
*[[IgG4-related systemic disease]]. | *[[IgG4-related systemic disease]]. | ||
*[[Plasmacytoid urothelial carcinoma]]. | |||
==References== | ==References== | ||