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Difference between revisions of "Autoimmune hepatitis"
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Autoimmune hepatitis (view source)
Revision as of 21:01, 30 September 2021
, 21:01, 30 September 2021PBC -> change to newer term
(→Images: a case of aih without significant fibrosis) |
(PBC -> change to newer term) |
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| Micro = interface hepatitis with plasma cells, +/- bile duct injury | | Micro = interface hepatitis with plasma cells, +/- bile duct injury | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[viral hepatitis]], [[primary biliary | | LMDDx = [[viral hepatitis]], [[primary biliary cholangitis]], AIH-[[PBC]] overlap, [[PSC]]-AIH overlap, [[drug reaction]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| Line 26: | Line 26: | ||
| Prognosis = poor without treatment | | Prognosis = poor without treatment | ||
| Other = | | Other = | ||
| ClinDDx = [[primary biliary | | ClinDDx = [[primary biliary cholangitis]], [[primary sclerosing cholangitis]] | ||
| Tx = corticosteroids, immunosuppression, liver transplant (end stage) | | Tx = corticosteroids, immunosuppression, liver transplant (end stage) | ||
}} | }} | ||
| Line 107: | Line 107: | ||
*[[Viral hepatitis]] - should have plasma cells. | *[[Viral hepatitis]] - should have plasma cells. | ||
*[[Drug-induced liver injury]] - milder changes than AIH, portal [[neutrophil]]s and [[cholestasis]].<ref>{{Cite journal | last1 = Suzuki | first1 = A. | last2 = Brunt | first2 = EM. | last3 = Kleiner | first3 = DE. | last4 = Miquel | first4 = R. | last5 = Smyrk | first5 = TC. | last6 = Andrade | first6 = RJ. | last7 = Lucena | first7 = MI. | last8 = Castiella | first8 = A. | last9 = Lindor | first9 = K. | title = The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury. | journal = Hepatology | volume = 54 | issue = 3 | pages = 931-9 | month = Sep | year = 2011 | doi = 10.1002/hep.24481 | PMID = 21674554 }}</ref> | *[[Drug-induced liver injury]] - milder changes than AIH, portal [[neutrophil]]s and [[cholestasis]].<ref>{{Cite journal | last1 = Suzuki | first1 = A. | last2 = Brunt | first2 = EM. | last3 = Kleiner | first3 = DE. | last4 = Miquel | first4 = R. | last5 = Smyrk | first5 = TC. | last6 = Andrade | first6 = RJ. | last7 = Lucena | first7 = MI. | last8 = Castiella | first8 = A. | last9 = Lindor | first9 = K. | title = The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury. | journal = Hepatology | volume = 54 | issue = 3 | pages = 931-9 | month = Sep | year = 2011 | doi = 10.1002/hep.24481 | PMID = 21674554 }}</ref> | ||
*[[Primary biliary | *[[Primary biliary cholangitis]]. | ||
*AIH-PBC overlap. | *AIH-PBC overlap. | ||
*PSC-AIH overlap. | *PSC-AIH overlap. | ||
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serology is suggested, if not done. | serology is suggested, if not done. | ||
The histology is not suggestive of primary biliary | The histology is not suggestive of primary biliary cholangitis. | ||
</pre> | </pre> | ||