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Difference between revisions of "NUT carcinoma"
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| LMDDx = [[Carcinoma ex pleomorphic adenoma]], [[squamous cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], acute leukemia, poorly differentiated carcinoma, | | LMDDx = [[Carcinoma ex pleomorphic adenoma]], [[squamous cell carcinoma]], [[SMARCB1-deficient sinonasal carcinoma]], acute leukemia, poorly differentiated carcinoma, | ||
| Stains = | | Stains = | ||
| IHC = p63 +ve, CD34 +ve/-ve, EMA +ve | | IHC = p63 +ve, CD34 +ve/-ve, EMA +ve, NUT +ve | ||
| EM = | | EM = | ||
| Molecular = t(15;19) | | Molecular = t(15;19) | ||
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==IHC== | ==IHC== | ||
*NUT +ve ('''key immunostain'''). | |||
*CD34 +ve seen in ~50% of cases.<ref name=pmid21221870>{{Cite journal | last1 = Stelow | first1 = EB. | title = A review of NUT midline carcinoma. | journal = Head Neck Pathol | volume = 5 | issue = 1 | pages = 31-5 | month = Mar | year = 2011 | doi = 10.1007/s12105-010-0235-x | PMID = 21221870 }}</ref> | *CD34 +ve seen in ~50% of cases.<ref name=pmid21221870>{{Cite journal | last1 = Stelow | first1 = EB. | title = A review of NUT midline carcinoma. | journal = Head Neck Pathol | volume = 5 | issue = 1 | pages = 31-5 | month = Mar | year = 2011 | doi = 10.1007/s12105-010-0235-x | PMID = 21221870 }}</ref> | ||
*p63 +ve.<ref name=pmid22534723>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Westra | first2 = WH. | title = NUT midline carcinomas of the sinonasal tract. | journal = Am J Surg Pathol | volume = 36 | issue = 8 | pages = 1216-21 | month = Aug | year = 2012 | doi = 10.1097/PAS.0b013e318254ce54 | PMID = 22534723 }}</ref> | *p63 +ve.<ref name=pmid22534723>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Westra | first2 = WH. | title = NUT midline carcinomas of the sinonasal tract. | journal = Am J Surg Pathol | volume = 36 | issue = 8 | pages = 1216-21 | month = Aug | year = 2012 | doi = 10.1097/PAS.0b013e318254ce54 | PMID = 22534723 }}</ref> | ||