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Difference between revisions of "Oncocytoma of the salivary gland"
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Oncocytoma of the salivary gland (view source)
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| Micro = abundant eosinophilic cytoplasm; architecture: solid, trabecular or duct-like | | Micro = abundant eosinophilic cytoplasm; architecture: solid, trabecular or duct-like | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[acinic cell carcinoma]], metastatic [[renal cell carcinoma]], oncocytic carcinoma | | LMDDx = [[acinic cell carcinoma]], metastatic [[renal cell carcinoma]], oncocytic carcinoma, [[granular cell tumour]] | ||
| Stains = | | Stains = | ||
| IHC = p63 +ve | | IHC = p63 +ve | ||
| Line 24: | Line 24: | ||
| Prevalence = very rare | | Prevalence = very rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = blends with normal salivary gland on T1 postcontrast and fat-saturated T2 MR images | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign | | Prognosis = benign | ||
| Line 40: | Line 40: | ||
*Associated with radiation exposure. | *Associated with radiation exposure. | ||
*Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal | last1 = Zhou | first1 = CX. | last2 = Gao | first2 = Y. | title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. | journal = Oral Oncol | volume = 45 | issue = 12 | pages = e232-8 | month = Dec | year = 2009 | doi = 10.1016/j.oraloncology.2009.08.004 | PMID = 19796983 }}</ref> | *Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal | last1 = Zhou | first1 = CX. | last2 = Gao | first2 = Y. | title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. | journal = Oral Oncol | volume = 45 | issue = 12 | pages = e232-8 | month = Dec | year = 2009 | doi = 10.1016/j.oraloncology.2009.08.004 | PMID = 19796983 }}</ref> | ||
*Case report of oncocytoma of parotid as manifestation of [[Birt-Hogg-Dubé syndrome]].<ref name=pmid29971177>{{cite journal |authors=Yoshida K, Miyagawa M, Kido T, Ide K, Sano Y, Sugawara Y, Takahata H, Monden N, Furuya M, Mochizuki T |title=Parotid Oncocytoma as a Manifestation of Birt-Hogg-Dubé Syndrome |journal=Case Rep Radiol |volume=2018 |issue= |pages=6265175 |date=2018 |pmid=29971177 |pmc=6008813 |doi=10.1155/2018/6265175 |url=}}</ref> | |||
==Gross== | ==Gross== | ||
*Golden brown appearance. | *Golden brown appearance. | ||
Note: | |||
*"Disappear" into background salivary gland on MRI: isointense to normal on fat-saturated T2 and T1 postcontrast images.<ref name=pmid21757520>{{Cite journal | last1 = Patel | first1 = ND. | last2 = van Zante | first2 = A. | last3 = Eisele | first3 = DW. | last4 = Harnsberger | first4 = HR. | last5 = Glastonbury | first5 = CM. | title = Oncocytoma: the vanishing parotid mass. | journal = AJNR Am J Neuroradiol | volume = 32 | issue = 9 | pages = 1703-6 | month = Oct | year = 2011 | doi = 10.3174/ajnr.A2569 | PMID = 21757520 }}</ref> | |||
===Image=== | ===Image=== | ||
<gallery> | <gallery> | ||
Image:Oncocytoma_of_the_Salivary_Gland.jpg | Salivary gland oncocytoma (WC/euthman) | Image:Oncocytoma_of_the_Salivary_Gland.jpg | Salivary gland oncocytoma (WC/euthman) | ||
</gallery> | </gallery> | ||
==Microscopic== | |||
Features: | Features: | ||
*Like [[oncocytoma]]s elsewhere. | *Like [[oncocytoma]]s elsewhere. | ||
| Line 61: | Line 64: | ||
DDx: | DDx: | ||
*[[Warthin tumour]] - have lymphocytes, classical bilayer. | |||
*[[Acinic cell carcinoma]]. | *[[Acinic cell carcinoma]]. | ||
*Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]]. | *Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]]. | ||
*Oncocytic carcinoma. | *Oncocytic carcinoma. | ||
*[[Granular cell tumour]]. | |||
===Images=== | ===Images=== | ||
| Line 76: | Line 81: | ||
==IHC== | ==IHC== | ||
*p63 +ve<ref name=pmid20614263>{{Cite journal | last1 = McHugh | first1 = JB. | last2 = Hoschar | first2 = AP. | last3 = Dvorakova | first3 = M. | last4 = Parwani | first4 = AV. | last5 = Barnes | first5 = EL. | last6 = Seethala | first6 = RR. | title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. | journal = Head Neck Pathol | volume = 1 | issue = 2 | pages = 123-31 | month = Dec | year = 2007 | doi = 10.1007/s12105-007-0031-4 | PMID = 20614263 | PMC = 2807526}}</ref> focally in nucleus. | *p63 +ve<ref name=pmid20614263>{{Cite journal | last1 = McHugh | first1 = JB. | last2 = Hoschar | first2 = AP. | last3 = Dvorakova | first3 = M. | last4 = Parwani | first4 = AV. | last5 = Barnes | first5 = EL. | last6 = Seethala | first6 = RR. | title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. | journal = Head Neck Pathol | volume = 1 | issue = 2 | pages = 123-31 | month = Dec | year = 2007 | doi = 10.1007/s12105-007-0031-4 | PMID = 20614263 | PMC = 2807526}}</ref> focally in nucleus. | ||
*DOG1 -ve.<ref name=pmid26425134>{{Cite journal | last1 = Canberk | first1 = S. | last2 = Onenerk | first2 = M. | last3 = Sayman | first3 = E. | last4 = Goret | first4 = CC. | last5 = Erkan | first5 = M. | last6 = Atasoy | first6 = T. | last7 = Kilicoglu | first7 = GZ. | title = Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature. | journal = Cytojournal | volume = 12 | issue = | pages = 18 | month = | year = 2015 | doi = 10.4103/1742-6413.162774 | PMID = 26425134 }}</ref> | |||
*PAX8 -ve.<ref name=pmid24771139>{{cite journal |authors=Butler RT, Alderman MA, Thompson LD, McHugh JB |title=Evaluation of PAX2 and PAX8 expression in salivary gland neoplasms |journal=Head Neck Pathol |volume=9 |issue=1 |pages=47–50 |date=March 2015 |pmid=24771139 |pmc=4382472 |doi=10.1007/s12105-014-0546-4 |url=}}</ref> | |||
==EM== | |||
*Increased numbers of mitochondria. | |||
==Sign out== | |||
<pre> | |||
Nodule, Right Parotid Gland, Core Biopsy: | |||
- ONCOCYTOMA. | |||
Comment: | |||
The tumour stains as follows: | |||
POSITIVE: p63 (focal, nuclear). | |||
NEGATIVE: CD10, RCC, S-100, CD68, vimentin. | |||
</pre> | |||
===Micro=== | |||
The sections show cells with abundant eosinophilic cytoplasm and bland round nuclei in a tubular architecture. Mitotic activity is not readily apparent. Significant nuclear atypia is absent. | |||
==See also== | ==See also== | ||