Difference between revisions of "Long-term epilepsy associated tumor"

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==General==
==General==
* Closely associated with [[Ganglioglioma]] and [[DNT]].
* Closely associated with [[Ganglioglioma]] and [[DNT]].
 
* Poor interobserver agreement. <ref name="pmid30326153">{{cite journal |authors=Blümcke I, Coras R, Wefers AK, Capper D, Aronica E, Becker A, Honavar M, Stone TJ, Jacques TS, Miyata H, Mühlebner A, Pimentel J, Söylemezoğlu F, Thom M |title=Review: Challenges in the histopathological classification of ganglioglioma and DNT: microscopic agreement studies and a preliminary genotype-phenotype analysis |journal=Neuropathol Appl Neurobiol |volume=45 |issue=2 |pages=95–107 |date=February 2019 |pmid=30326153 |doi=10.1111/nan.12522 |url=}}</ref>
* Some entities can be molecularly defined.<ref name="pmid30759284">{{cite journal |authors=Hou Y, Pinheiro J, Sahm F, Reuss DE, Schrimpf D, Stichel D, Casalini B, Koelsche C, Sievers P, Wefers AK, Reinhardt A, Ebrahimi A, Fernández-Klett F, Pusch S, Meier J, Schweizer L, Paulus W, Prinz M, Hartmann C, Plate KH, Reifenberger G, Pietsch T, Varlet P, Pagès M, Schüller U, Scheie D, de Stricker K, Frank S, Hench J, Pollo B, Brandner S, Unterberg A, Pfister SM, Jones DTW, Korshunov A, Wick W, Capper D, Blümcke I, von Deimling A, Bertero L |title=Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA |journal=Acta Neuropathol |volume=137 |issue=5 |pages=837–846 |date=May 2019 |pmid=30759284 |doi=10.1007/s00401-019-01969-2 |url=}}</ref> - but some not.


==Examples==
==Examples==
* Papillary glioneuronal tumor
* Papillary glioneuronal tumor <ref name="pmid23173837">{{cite journal |authors=Demetriades AK, Al Hyassat S, Al-Sarraj S, Bhangoo RS, Ashkan K |title=Papillary glioneuronal tumour: a review of the literature with two illustrative cases |journal=Br J Neurosurg |volume=27 |issue=3 |pages=401–4 |date=June 2013 |pmid=23173837 |doi=10.3109/02688697.2012.741735 |url=}}</ref>
* [[Angiocentric glioma]]
* [[Angiocentric glioma]] <ref name="pmid26948368">{{cite journal |authors=Soffietti R, Rudà R, Reardon D |title=Rare glial tumors |journal=Handb Clin Neurol |volume=134 |issue= |pages=399–415 |date=2016 |pmid=26948368 |doi=10.1016/B978-0-12-802997-8.00024-4 |url=}}</ref>
* Isomorphic diffuse glioma
* Isomorphic diffuse glioma <ref name="pmid31563982">{{cite journal |authors=Wefers AK, Stichel D, Schrimpf D, Coras R, Pages M, Tauziède-Espariat A, Varlet P, Schwarz D, Söylemezoglu F, Pohl U, Pimentel J, Meyer J, Hewer E, Japp A, Joshi A, Reuss DE, Reinhardt A, Sievers P, Casalini MB, Ebrahimi A, Huang K, Koelsche C, Low HL, Rebelo O, Marnoto D, Becker AJ, Staszewski O, Mittelbronn M, Hasselblatt M, Schittenhelm J, Cheesman E, de Oliveira RS, Queiroz RGP, Valera ET, Hans VH, Korshunov A, Olar A, Ligon KL, Pfister SM, Jaunmuktane Z, Brandner S, Tatevossian RG, Ellison DW, Jacques TS, Honavar M, Aronica E, Thom M, Sahm F, von Deimling A, Jones DTW, Blumcke I, Capper D |title=Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course |journal=Acta Neuropathol |volume=139 |issue=1 |pages=193–209 |date=January 2020 |pmid=31563982 |pmc=7477753 |doi=10.1007/s00401-019-02078-w |url=}}</ref>
* Multinodular and vacuolating neuronal tumor of the cerebrum
* Multinodular and vacuolating neuronal tumor of the cerebrum <ref name="pmid32979644">{{cite journal |authors=Alizada O, Ayman T, Akgun MY, Sar M, Urganci N, Kemerdere R |title=Multinodular and vacuolating neuronal tumor of the cerebrum: Two cases and review of the literature |journal=Clin Neurol Neurosurg |volume=197 |issue= |pages=106149 |date=October 2020 |pmid=32979644 |doi=10.1016/j.clineuro.2020.106149 |url=}}</ref>
* Polymorphous low grade tumor of the young
* Polymorphous low grade tumor of the young <ref name="pmid27812792">{{cite journal |authors=Huse JT, Snuderl M, Jones DT, Brathwaite CD, Altman N, Lavi E, Saffery R, Sexton-Oates A, Blumcke I, Capper D, Karajannis MA, Benayed R, Chavez L, Thomas C, Serrano J, Borsu L, Ladanyi M, Rosenblum MK |title=Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway |journal=Acta Neuropathol |volume=133 |issue=3 |pages=417–429 |date=March 2017 |pmid=27812792 |pmc=5325850 |doi=10.1007/s00401-016-1639-9 |url=}}</ref>




==Criteria==
==Criteria==
See <ref name="pmid32151273">{{cite journal |authors=Slegers RJ, Blumcke I |title=Low-grade developmental and epilepsy associated brain tumors: a critical update 2020 |journal=Acta Neuropathol Commun |volume=8 |issue=1 |pages=27 |date=March 2020 |pmid=32151273 |pmc=7063704 |doi=10.1186/s40478-020-00904-x |url=}}</ref>
* Seizures <18 years.
* Seizures <18 years.
* Temporal lobe location.
* Temporal lobe location.

Latest revision as of 17:11, 25 March 2021

Long-term epilepsy associated tumors, abbreviated LEAT is an umbrella term for rare tumor entities in patients that do not match current WHO diagnostic criteria.

General

  • Closely associated with Ganglioglioma and DNT.
  • Poor interobserver agreement. [1]
  • Some entities can be molecularly defined.[2] - but some not.

Examples

  • Papillary glioneuronal tumor [3]
  • Angiocentric glioma [4]
  • Isomorphic diffuse glioma [5]
  • Multinodular and vacuolating neuronal tumor of the cerebrum [6]
  • Polymorphous low grade tumor of the young [7]


Criteria

See [8]

  • Seizures <18 years.
  • Temporal lobe location.
  • Mostly benign appearance (as in WHO grade I).

See also

References

  1. ↑ Blümcke I, Coras R, Wefers AK, Capper D, Aronica E, Becker A, Honavar M, Stone TJ, Jacques TS, Miyata H, Mühlebner A, Pimentel J, Söylemezoğlu F, Thom M (February 2019). "Review: Challenges in the histopathological classification of ganglioglioma and DNT: microscopic agreement studies and a preliminary genotype-phenotype analysis". Neuropathol Appl Neurobiol 45 (2): 95–107. doi:10.1111/nan.12522. PMID 30326153.
  2. ↑ Hou Y, Pinheiro J, Sahm F, Reuss DE, Schrimpf D, Stichel D, Casalini B, Koelsche C, Sievers P, Wefers AK, Reinhardt A, Ebrahimi A, Fernández-Klett F, Pusch S, Meier J, Schweizer L, Paulus W, Prinz M, Hartmann C, Plate KH, Reifenberger G, Pietsch T, Varlet P, Pagès M, Schüller U, Scheie D, de Stricker K, Frank S, Hench J, Pollo B, Brandner S, Unterberg A, Pfister SM, Jones DTW, Korshunov A, Wick W, Capper D, Blümcke I, von Deimling A, Bertero L (May 2019). "Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA". Acta Neuropathol 137 (5): 837–846. doi:10.1007/s00401-019-01969-2. PMID 30759284.
  3. ↑ Demetriades AK, Al Hyassat S, Al-Sarraj S, Bhangoo RS, Ashkan K (June 2013). "Papillary glioneuronal tumour: a review of the literature with two illustrative cases". Br J Neurosurg 27 (3): 401–4. doi:10.3109/02688697.2012.741735. PMID 23173837.
  4. ↑ Soffietti R, Rudà R, Reardon D (2016). "Rare glial tumors". Handb Clin Neurol 134: 399–415. doi:10.1016/B978-0-12-802997-8.00024-4. PMID 26948368.
  5. ↑ Wefers AK, Stichel D, Schrimpf D, Coras R, Pages M, Tauziède-Espariat A, Varlet P, Schwarz D, Söylemezoglu F, Pohl U, Pimentel J, Meyer J, Hewer E, Japp A, Joshi A, Reuss DE, Reinhardt A, Sievers P, Casalini MB, Ebrahimi A, Huang K, Koelsche C, Low HL, Rebelo O, Marnoto D, Becker AJ, Staszewski O, Mittelbronn M, Hasselblatt M, Schittenhelm J, Cheesman E, de Oliveira RS, Queiroz RGP, Valera ET, Hans VH, Korshunov A, Olar A, Ligon KL, Pfister SM, Jaunmuktane Z, Brandner S, Tatevossian RG, Ellison DW, Jacques TS, Honavar M, Aronica E, Thom M, Sahm F, von Deimling A, Jones DTW, Blumcke I, Capper D (January 2020). "Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course". Acta Neuropathol 139 (1): 193–209. doi:10.1007/s00401-019-02078-w. PMC 7477753. PMID 31563982. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477753/.
  6. ↑ Alizada O, Ayman T, Akgun MY, Sar M, Urganci N, Kemerdere R (October 2020). "Multinodular and vacuolating neuronal tumor of the cerebrum: Two cases and review of the literature". Clin Neurol Neurosurg 197: 106149. doi:10.1016/j.clineuro.2020.106149. PMID 32979644.
  7. ↑ Huse JT, Snuderl M, Jones DT, Brathwaite CD, Altman N, Lavi E, Saffery R, Sexton-Oates A, Blumcke I, Capper D, Karajannis MA, Benayed R, Chavez L, Thomas C, Serrano J, Borsu L, Ladanyi M, Rosenblum MK (March 2017). "Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway". Acta Neuropathol 133 (3): 417–429. doi:10.1007/s00401-016-1639-9. PMC 5325850. PMID 27812792. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325850/.
  8. ↑ Slegers RJ, Blumcke I (March 2020). "Low-grade developmental and epilepsy associated brain tumors: a critical update 2020". Acta Neuropathol Commun 8 (1): 27. doi:10.1186/s40478-020-00904-x. PMC 7063704. PMID 32151273. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063704/.
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