Difference between revisions of "Lymph node pathology"

Lymph node pathology (view source)

973 bytes removed , 15:16, 16 February 2021

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 *Neoplastic - lymphoma, carcinoma.
 *Endocrine - [[hyperthyroidism]].
 *Trauma.
 *Autoimmune - [[SLE]], [[RA]], [[dermatomyositis]].
 *Inflammatory - drugs (phenytoin).
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 ==Reactive follicular hyperplasia==
-===General===
+{{Main|Reactive follicular hyperplasia}}
-*Many causes - including: bacteria, viruses, chemicals, drugs, allergens.
-**In only approximately 10% can definitive cause be identified.<ref name=Ref_ILNP174>{{Ref_ILNP|174}}</ref>
-===Microscopic===
-Features:<ref name=Ref_ILNP179>{{Ref_ILNP|179}}</ref>
-*Enlarged follicles, follicle size variation - '''key feature''' with:
-**Large germinal centers (pale on H&E).
-***Mitoses common.
-***Variable lymphocyte morphology.
-***Tingible-body macrophage (large, pale cells with junk in the cytoplasm).
-***Germinal centers (GCs) have a crisp/sharp edge.
-***Normal dark/light variation of GCs; superficial aspect light, deeper aspect darker.
-**Rim of small (inactive) lymphocytes.
-DDx:
-*[[Hodgkin lymphoma]] - with rare Reed-Sternberg cells.
-*Non-Hodgkin [[lymphoma]].
-**T-cell/histiocyte-rich large B cell lymphoma.
-Image: [http://pleiad.umdnj.edu/hemepath/normal_node/normal_node.html Normal lymph node (umdnj.edu)].
-===IHC===
-Screening panel:
-*CD3.
-*CD5.
-*CD10.
-*CD20.
-*CD30.
-*CD15.
-Others:
-*BCL2 -ve.
 ==Diffuse paracortical hyperplasia==