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Difference between revisions of "Fibroadenoma"
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| Prevalence = very common | | Prevalence = very common | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = typically BIRADS4 - see ''[[BIRADS]]'' | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign | | Prognosis = benign | ||
| Line 30: | Line 30: | ||
| Tx = conservative excision | | Tx = conservative excision | ||
}} | }} | ||
'''Fibroadenoma''' is a common benign tumour of the [[breast]]. | '''Fibroadenoma''', abbreviated '''FA''', is a common benign tumour of the [[breast]]. | ||
It is a type of [[fibroepithelial tumours of the breast|fibroepithelial tumour]]. | |||
==General== | ==General== | ||
| Line 116: | Line 118: | ||
*Cellular. | *Cellular. | ||
*Mitoses. | *Mitoses. | ||
Note: | |||
*"Cellular" is something that can be subjective. One definition of "cellular" is: "stromal cells are touching one another". Jacobs ''et al.'' has a stromal cellularity picture gallery showing ''mild'' (rare stromal cells touching), ''moderate'' and ''marked'' (many stromal cells touching).<ref name=pmid16191502>{{Cite journal | last1 = Jacobs | first1 = TW. | last2 = Chen | first2 = YY. | last3 = Guinee | first3 = DG. | last4 = Holden | first4 = JA. | last5 = Cha | first5 = I. | last6 = Bauermeister | first6 = DE. | last7 = Hashimoto | first7 = B. | last8 = Wolverton | first8 = D. | last9 = Hartzog | first9 = G. | title = Fibroepithelial lesions with cellular stroma on breast core needle biopsy: are there predictors of outcome on surgical excision? | journal = Am J Clin Pathol | volume = 124 | issue = 3 | pages = 342-54 | month = Sep | year = 2005 | doi = 10.1309/5N2C-4N5X-CB8X-W8JL | PMID = 16191502 }}</ref> | |||
====Complex fibroadenoma==== | ====Complex fibroadenoma==== | ||
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====Tubular adenoma of the breast==== | ====Tubular adenoma of the breast==== | ||
*Considered by many a variant of ''fibroadenoma''. | *Considered by many a variant of ''fibroadenoma''. | ||
**[[IHC]] features of ''tubular adenoma of the breast'' and ''fibroadenoma'' are similar.<ref>{{Cite journal | last1 = Maiorano | first1 = E. | last2 = Albrizio | first2 = M. | title = Tubular adenoma of the breast: an immunohistochemical study of ten cases. | journal = Pathol Res Pract | volume = 191 | issue = 12 | pages = 1222-30 | month = Dec | year = 1995 | doi = | PMID = 8927570 }}</ref> | **[[IHC]] features of ''[[tubular adenoma]] of the breast'' and ''fibroadenoma'' are similar.<ref>{{Cite journal | last1 = Maiorano | first1 = E. | last2 = Albrizio | first2 = M. | title = Tubular adenoma of the breast: an immunohistochemical study of ten cases. | journal = Pathol Res Pract | volume = 191 | issue = 12 | pages = 1222-30 | month = Dec | year = 1995 | doi = | PMID = 8927570 }}</ref> | ||
*Most present in adults between menarche and menopause. | |||
Features:<ref name=Ref_BP116>{{Ref BP|116}}</ref> | Features:<ref name=Ref_BP116>{{Ref BP|116}}</ref> | ||
* | *Well circumscribed lesion. | ||
* | *Closely packed uniform tubules, lined by a single layer of epithelial cells and an attenuated myoepithelial cell layer. | ||
*Stroma is generally more sparse than in conventional fibroadenoma | |||
Images: | Images: | ||
*[http://www.webpathology.com/image.asp?case=277&n=1 Tubular adenoma of the breast (webpathology.com)]. | *[http://www.webpathology.com/image.asp?case=277&n=1 Tubular adenoma of the breast (webpathology.com)]. | ||
<gallery> | <gallery> | ||
Image:Breast TubularAdenoma LP CTR.jpg|Breast - Tubular Adenoma - low power (SKB) | |||
Image:Breast TubularAdenoma MP CTR.jpg|Breast - Tubular Adenoma - medium power (SKB) | |||
Image:Breast TubularAdenoma HP CTR.jpg|Breast - Tubular Adenoma - high power (SKB) | |||
Image:Breast TubularAdenoma LP SNP.jpg|Breast - Tubular Adenoma - low power (SKB) | |||
Image:Breast TubularAdenoma MP SNP.jpg|Breast - Tubular Adenoma - medium power (SKB) | |||
Image:Breast TubularAdenoma LactationalChange pa.JPG|Breast - Tubular Adenoma with lactational change (SKB) | |||
Image:Tubular_Adenoma_of_Breast_(myosin_immunostain)_(4351463966).jpg | TA of the breast - myosin IHC. (WC) | Image:Tubular_Adenoma_of_Breast_(myosin_immunostain)_(4351463966).jpg | TA of the breast - myosin IHC. (WC) | ||
</gallery> | </gallery> | ||
==Sign out== | |||
<pre> | |||
Right Partial Breast, Lumpectomy: | |||
- Fibroadenoma. | |||
</pre> | |||
====Micro==== | |||
The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. No apparent proliferative activity is present. The border is well-circumscribed where seen. Focally, the lesion approaches the inked margin; partial lesion transection cannot be excluded. | |||
No cytologic atypia is present. No leaf-like architecture is present. No stromal overgrowth is seen. No calcifications are evident. No large cysts are seen. | |||
===Complex=== | |||
<pre> | |||
Right Breast, Lumpectomy: | |||
- Complex fibroadenoma with apocrine metaplasia. | |||
- Negative for carcinoma in situ and negative for malignancy. | |||
</pre> | |||
====Micro==== | |||
The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. Minimal mitotic activity is present (2 mitosis/10 HPF, where 1 HPF ~ 0.2376 mm*mm). The border is well-circumscribed where seen. The lesion was shelled-out. | |||
No cytologic atypia is present. No leaf-like architecture is present. No stromal overgrowth is seen. No calcifications are evident. No large cysts are seen. | |||
==See also== | ==See also== | ||