Difference between revisions of "Long-term epilepsy associated tumor"

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==General==
==General==
* Closely associated with [[Ganglioglioma]] and [[DNT]].
* Closely associated with [[Ganglioglioma]] and [[DNT]].
 
* Poor interobserver agreement. <ref name="pmid30326153">{{cite journal |vauthors=Blümcke I, Coras R, Wefers AK, Capper D, Aronica E, Becker A, Honavar M, Stone TJ, Jacques TS, Miyata H, Mühlebner A, Pimentel J, Söylemezoğlu F, Thom M |title=Review: Challenges in the histopathological classification of ganglioglioma and DNT: microscopic agreement studies and a preliminary genotype-phenotype analysis |journal=Neuropathol Appl Neurobiol |volume=45 |issue=2 |pages=95–107 |date=February 2019 |pmid=30326153 |doi=10.1111/nan.12522 |url=}}</ref>
* Some entities can be molecularly defined.<ref name="pmid30759284">{{cite journal |vauthors=Hou Y, Pinheiro J, Sahm F, Reuss DE, Schrimpf D, Stichel D, Casalini B, Koelsche C, Sievers P, Wefers AK, Reinhardt A, Ebrahimi A, Fernández-Klett F, Pusch S, Meier J, Schweizer L, Paulus W, Prinz M, Hartmann C, Plate KH, Reifenberger G, Pietsch T, Varlet P, Pagès M, Schüller U, Scheie D, de Stricker K, Frank S, Hench J, Pollo B, Brandner S, Unterberg A, Pfister SM, Jones DTW, Korshunov A, Wick W, Capper D, Blümcke I, von Deimling A, Bertero L |title=Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA |journal=Acta Neuropathol |volume=137 |issue=5 |pages=837–846 |date=May 2019 |pmid=30759284 |doi=10.1007/s00401-019-01969-2 |url=}}</ref> - but some not.


==Examples==
==Examples==

Revision as of 15:06, 6 November 2020

Long-term epilepsy associated tumors, abbreviated LEAT is an umbrella term for rare tumor entities in patients that do not match current WHO diagnostic criteria.

General

  • Closely associated with Ganglioglioma and DNT.
  • Poor interobserver agreement. [1]
  • Some entities can be molecularly defined.[2] - but some not.

Examples

  • Papillary glioneuronal tumor [3]
  • Angiocentric glioma [4]
  • Isomorphic diffuse glioma [5]
  • Multinodular and vacuolating neuronal tumor of the cerebrum [6]
  • Polymorphous low grade tumor of the young [7]


Criteria

See [8]

  • Seizures <18 years.
  • Temporal lobe location.
  • Mostly benign appearance (as in WHO grade I).

See also

References

  1. ↑ "Review: Challenges in the histopathological classification of ganglioglioma and DNT: microscopic agreement studies and a preliminary genotype-phenotype analysis". Neuropathol Appl Neurobiol 45 (2): 95–107. February 2019. doi:10.1111/nan.12522. PMID 30326153.
  2. ↑ "Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA". Acta Neuropathol 137 (5): 837–846. May 2019. doi:10.1007/s00401-019-01969-2. PMID 30759284.
  3. ↑ "Papillary glioneuronal tumour: a review of the literature with two illustrative cases". Br J Neurosurg 27 (3): 401–4. June 2013. doi:10.3109/02688697.2012.741735. PMID 23173837.
  4. ↑ "Rare glial tumors". Handb Clin Neurol 134: 399–415. 2016. doi:10.1016/B978-0-12-802997-8.00024-4. PMID 26948368.
  5. ↑ "Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course". Acta Neuropathol 139 (1): 193–209. January 2020. doi:10.1007/s00401-019-02078-w. PMC 7477753. PMID 31563982. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477753/.
  6. ↑ "Multinodular and vacuolating neuronal tumor of the cerebrum: Two cases and review of the literature". Clin Neurol Neurosurg 197: 106149. October 2020. doi:10.1016/j.clineuro.2020.106149. PMID 32979644.
  7. ↑ "Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway". Acta Neuropathol 133 (3): 417–429. March 2017. doi:10.1007/s00401-016-1639-9. PMC 5325850. PMID 27812792. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325850/.
  8. ↑ "Low-grade developmental and epilepsy associated brain tumors: a critical update 2020". Acta Neuropathol Commun 8 (1): 27. March 2020. doi:10.1186/s40478-020-00904-x. PMC 7063704. PMID 32151273. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063704/.
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