Dermatopathology: Difference between revisions
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*Melanocytes. | *Melanocytes. | ||
**Usuallly basal location. | **Usuallly basal location. | ||
**Epithelioid or | **Epithelioid or dendritic morphology. | ||
**Pericellular clearing - '''key feature'''. | **Pericellular clearing - '''key feature'''. | ||
**Clear cytoplasm. | **Clear cytoplasm. | ||
| Line 261: | Line 261: | ||
*[[Basal cell carcinoma]] (BCC). | *[[Basal cell carcinoma]] (BCC). | ||
*[[Malignant melanoma]]. | *[[Malignant melanoma]]. | ||
* | *Metastases. | ||
==Non-malignant disease== | ==Non-malignant disease== | ||
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</gallery> | </gallery> | ||
A. Extending from papillary dermis into dermis is a chronic, blue inflammatory infiltrate. B. The infiltrate comprises lymphocytes, plasma cells, and macrophages. C. At the edge of the biopsy pink strews inflammatory cells; this pink invasion of inflammation, so to speak, is a good place to look for organisms. D. High power reveals sometimes budding yeast forms in clear spaces. | A. Extending from papillary dermis into dermis is a chronic, blue inflammatory infiltrate. B. The infiltrate comprises lymphocytes, plasma cells, and macrophages. C. At the edge of the biopsy pink strews inflammatory cells; this pink invasion of inflammation, so to speak, is a good place to look for organisms. D. High power reveals sometimes budding yeast forms in clear spaces. | ||
===Herpes Zoster=== | |||
<gallery> | |||
File:5.049889044 sl 1.png| Changes of herpes zoster (A) | |||
File:5.049889044 sl 2.png| Changes of herpes zoster (B) | |||
File:5.049889044 sl 3.png| Changes of herpes zoster (C) | |||
File:5.049889044 sl 4.png| Changes of herpes zoster (D) | |||
</gallery> | |||
Changes of herpes zoster in lower right abdominal skin of a 48 yo Hispanic man. A. Note the edema at the dermoepidermal junction along with a focal separation at the left as well as the inflamed superficial and deep blood vessels. B,C. Careful examination along the junction uncovers smudged chromatin diagnostic of viral infection. D. Vasculitis associated changes include extravasated neutrophils with nuclear dust, as well as pervascular macrophages, lymphocytes and occasional eosinophils. | |||
=References= | =References= | ||