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Difference between revisions of "Desmoplastic small round cell tumour"
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Desmoplastic small round cell tumour (view source)
Revision as of 11:10, 21 January 2020
, 11:10, 21 January 2020→IHC: WT nuclear + CAM5.2
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Jensflorian (talk | contribs) (→IHC: WT nuclear + CAM5.2) |
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| Micro = small (round) cells in nests with an undulating sharp border, road bands of paucicellular fibrous stroma | | Micro = small (round) cells in nests with an undulating sharp border, road bands of paucicellular fibrous stroma | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[ | | LMDDx = solid variant of [[alveolar rhabdomyosarcoma]], [[embryonal rhabdomyosarcoma]], other [[small round cell tumours]] | ||
| Stains = | | Stains = | ||
| IHC = AE1/AE3 +ve, desmin +ve, EMA +ve, actin -ve, WT1 (N-terminal) -ve, WT1 (C-terminal) +ve, CD57 +ve. | | IHC = AE1/AE3 +ve, desmin +ve, EMA +ve, actin -ve, WT1 (N-terminal) -ve, WT1 (C-terminal) +ve, CD57 +ve. | ||
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*Typically retroperitoneal. | *Typically retroperitoneal. | ||
*Poor prognosis. | *Poor prognosis. | ||
==Clinics== | |||
*Rare cases in the CNS reported. | |||
==Microscopic== | ==Microscopic== | ||
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*Solid variant of [[alveolar RMS]]. | *Solid variant of [[alveolar RMS]]. | ||
**Nests in alveolar RMS have round edges. | **Nests in alveolar RMS have round edges. | ||
*Other [[small round cell tumours]]. | |||
===Images=== | ===Images=== | ||
| Line 62: | Line 66: | ||
==IHC== | ==IHC== | ||
Features: | Features: | ||
*AE1/AE3 +ve. | *[[AE1/AE3]] +ve. | ||
*Desmin +ve. | *CAM5.2 usu -ve. | ||
*EMA +ve. | *Desmin +ve (strongly). | ||
*[[EMA]] +ve. | |||
*Actin -ve. | *Actin -ve. | ||
* | *[[WT-1]] (N-terminal) -ve. | ||
* | *[[WT-1]] (C-terminal) +ve (nuclear staining). | ||
*CD57 +ve. | *CD57 +ve. | ||
*[[Synaptophysin]] focal, patchy +ve. | |||
==Molecular== | ==Molecular== | ||
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==See also== | ==See also== | ||
*[[Soft tissue lesions]]. | *[[Soft tissue lesions]]. | ||
*[[Small round cell tumours]]. | |||
*[[Stromal desmoplasia]]. | |||
==References== | ==References== | ||
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[[Category:Soft tissue lesions]] | [[Category:Soft tissue lesions]] | ||
[[Category:Neuropathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||