Difference between revisions of "Medullary colorectal carcinoma"
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DDx: | DDx: | ||
*Other (poorly differentiated) [[colorectal carcinoma]]s. | *Other (poorly differentiated) [[colorectal carcinoma]]s. | ||
*Carcinomas with neuroendocrine differentiation. | |||
==IHC== | ==IHC== | ||
Revision as of 18:37, 31 December 2019
Medullary colorectal carcinoma is a rare type of colorectal carcinoma.
General
- Rare subtype of colorectal carcinoma.
- Typically has Microsatellite instability.[1]
- Prognostic significance dependent on study.
Gross
- Well-circumscribed.
Microscopic
Features:
- Poorly differentiated carcinoma:
- Noninfiltrative border.
- Solid pattern/nests.
- No gland formation.
- Lymphocytic infiltrate.
DDx:
- Other (poorly differentiated) colorectal carcinomas.
- Carcinomas with neuroendocrine differentiation.
IHC
Features:[1]
- CDX2 +ve.
- Beta-catenin +ve.
- MLH1 loss of staining.
Note:
- CDX2, beta-catenin, MLH1 useful for differentiating from poorly differentiated colorectal carcinoma.
See also
References
- ↑ 1.0 1.1 "Medullary carcinoma of the colon: a case series and review of the literature". In Vivo 28 (3): 311–4. 2014. PMID 24815832.
- ↑ "Medullary colonic carcinoma with microsatellite instability has lower survival compared with conventional colonic adenocarcinoma with microsatellite instability". Prz Gastroenterol 12 (3): 208–214. 2017. doi:10.5114/pg.2016.64740. PMC 5672702. PMID 29123583. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672702/.
- ↑ "Medullary colorectal carcinoma revisited: a clinical and pathological study of 102 cases". Ann. Surg. Oncol. 22 (9): 2988–96. September 2015. doi:10.1245/s10434-014-4355-5. PMID 25572685.