Difference between revisions of "Epstein-Barr virus-associated smooth muscle tumour"

From Libre Pathology
Jump to navigation Jump to search
(more)
 
(2 intermediate revisions by the same user not shown)
Line 2: Line 2:


==General==
==General==
*Immunosuppressed individuals.
*Immunosuppressed individuals, e.g. individuals with [[HIV]].
*Caused by [[Epstein-Barr virus]].
*Caused by [[Epstein-Barr virus]].


Line 20: Line 20:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996495/figure/Fig2/ EBV-EMT (nih.gov)].<ref name=pmid20690046>{{Cite journal  | last1 = Huang | first1 = J. | last2 = Loh | first2 = KS. | last3 = Petersson | first3 = F. | title = Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma. | journal = Head Neck Pathol | volume = 4 | issue = 4 | pages = 300-4 | month = Dec | year = 2010 | doi = 10.1007/s12105-010-0201-7 | PMID = 20690046 }}
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996495/figure/Fig2/ EBV-EMT (nih.gov)].<ref name=pmid20690046>{{Cite journal  | last1 = Huang | first1 = J. | last2 = Loh | first2 = KS. | last3 = Petersson | first3 = F. | title = Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma. | journal = Head Neck Pathol | volume = 4 | issue = 4 | pages = 300-4 | month = Dec | year = 2010 | doi = 10.1007/s12105-010-0201-7 | PMID = 20690046 }}
</ref>
</ref>
==Stains==
*EBER +ve.<ref name=pmid20690046/>


==IHC==
==IHC==
Line 32: Line 29:
Image:
Image:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996495/figure/Fig4/ EBV-SMT (nih.gov)].
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996495/figure/Fig4/ EBV-SMT (nih.gov)].
==Molecular==
*[[EBER]] +ve.<ref name=pmid20690046/>


==References==
==References==

Latest revision as of 18:03, 29 December 2019

Epstein-Barr virus-associated smooth muscle tumour, abbreviated EBV-SMT, is a very uncommon soft tissue lesion.[1]

General

Microscopic

Features:[1]

  • Smooth muscle lesion:
    • Spindle cells in a fascicular arrangement.
    • Usually minimal nuclear atypia and few mitoses.
  • Lymphocytes.

DDx:

Image:

IHC

  • SMA +ve
  • Desmin +ve/-ve.
  • CD34 -ve.
  • CD117 -ve.

Image:

Molecular

References

  1. 1.0 1.1 Deyrup, AT.; Lee, VK.; Hill, CE.; Cheuk, W.; Toh, HC.; Kesavan, S.; Chan, EW.; Weiss, SW. (Jan 2006). "Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients.". Am J Surg Pathol 30 (1): 75-82. PMID 16330945.
  2. 2.0 2.1 Huang, J.; Loh, KS.; Petersson, F. (Dec 2010). "Epstein-barr virus-associated smooth muscle tumor of the larynx: report of a rare case mimicking leiomyosarcoma.". Head Neck Pathol 4 (4): 300-4. doi:10.1007/s12105-010-0201-7. PMID 20690046.