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Difference between revisions of "Liver metastasis"
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(→Micro: add met thyroid carcinoma) |
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| LMDDx = primary liver lesions ([[cholangiocarcinoma]], [[hepatocellular carcinoma]] (esp. pseudoglandular), [[epithelioid hemangioendothelioma]]) | | LMDDx = primary liver lesions ([[cholangiocarcinoma]], [[hepatocellular carcinoma]] (esp. pseudoglandular), [[epithelioid hemangioendothelioma]]) | ||
| Stains = | | Stains = | ||
| IHC = HepPar-1 -ve, CK20 +ve (colorectal carcinoma) | | IHC = [[HepPar-1]] -ve, [[CK20]] +ve (colorectal carcinoma) | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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==IHC== | ==IHC== | ||
*Metastases are typically negative for ''HepPar-1''. | *Metastases are typically negative for ''HepPar-1''. | ||
**HepPar-1 (hepatocytes paraffin antibody 1) - labels hepatocellular mitochondria.<ref name=pmid12502967>The diagnostic value of hepatocyte paraffin antibody 1 in differentiating hepatocellular neoplasms from nonhepatic tumors: a review. Lamps LW, Folpe AL. Adv Anat Pathol. 2003 Jan;10(1):39-43. Review. PMID 12502967.</ref> | **[[HepPar-1]] (hepatocytes paraffin antibody 1) - labels hepatocellular mitochondria.<ref name=pmid12502967>The diagnostic value of hepatocyte paraffin antibody 1 in differentiating hepatocellular neoplasms from nonhepatic tumors: a review. Lamps LW, Folpe AL. Adv Anat Pathol. 2003 Jan;10(1):39-43. Review. PMID 12502967.</ref> | ||
A panel: | A panel: | ||
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====Micro==== | ====Micro==== | ||
The section show liver parenchyma with an invasive adenocarcinoma. The adenocarcinoma | |||
has well formed glands with dirty necrosis. The nuclei are appear crowded and | |||
have an ellipsoid shape. Focally, zones of necrosis are present. See background liver. | |||
BACKGROUND LIVER (BASED ON H&E ONLY)<br> | |||
Fibrosis: not identified.<br> | |||
Fibrous septa: absent.<br> | |||
Septa with curved contours: absent.<br> | |||
Large droplet steatosis (% of hepatocytes): mild (20%).<br> | |||
Ballooning of hepatocytes: not identified.<br> | |||
Mallory-Denk bodies: not identified.<br> | |||
Portal inflammation: present, mild.<br> | |||
Interface activity: not identified.<br> | |||
Lobular necroinflammation: not identified.<br> | |||
Ducts: present in normal numbers.<br> | |||
Duct injury: not identified.<br> | |||
Ductular reaction: not identified.<br> | |||
Cholestasis: present peritumoural, otherwise absent.<br> | |||
Terminal hepatic venules: present.<br> | |||
Ground glass cells with routine stains: not identified. | |||
[[File: COL MET 1 sl 1.png| Metastasis of colonic carcinoma to liver]] | |||
[[File: COL MET 1 sl 2.png| Metastasis of colonic carcinoma to liver]] | |||
[[File: COL MET 1 sl 3.png| Metastasis of colonic carcinoma to liver]] | |||
[[File: COL MET 1 sl 4.png| Metastasis of colonic carcinoma to liver]] | |||
[[File: COL MET 1 sl 5.png| Metastasis of colonic carcinoma to liver]] | |||
Metastasis of colonic carcinoma to liver. A. Blue arrow shows colon cancer with large acini. Green arrow shows necrotic tumor. Black arrow shows sinusoidal dilatation, an example of a nonspecific tumor associated change that should not be deemed systemic in nature. B. Elongated nuclei perpendicular to acinar border (green arrows) and dirty luminal necrosis (black arrow) are characteristic of colon cancer. C. Immunostain for CK7. Positive groups may be focal staining by tumor, but more likely are residual bile ductules. D. Immunostain for CK20 is more diffusely positive and definitely in tumor. | |||
[[File: SQC MET 1 sl 1.png| Metastasis of squamous carcinoma to liver]] | |||
[[File: SQC MET 1 sl 2.png| Metastasis of squamous carcinoma to liver]] | |||
[[File: SQC MET 1 sl 3.png| Metastasis of squamous carcinoma to liver]] | |||
[[File: SQC MET 1 sl 4.png| Metastasis of squamous carcinoma to liver]] | |||
[[File: SQC MET 1 sl 5.png| Metastasis of squamous carcinoma to liver]] | |||
Metastasis of Squamous carcinoma to liver. A. Dark blue tumor groups mass to replace liver.B. Carcinomatous nests show scant stromal separation, with individual cancer cells being a the edge of the necrotic space C. Huge nucle show nucleoli with occasional spindleds cell nuclei. Individual cell necrosis is prominent. Cytoplasm is scant. Immunostain for CK7. Positive groups may be focal staining by tumor, but more likely are residual bile ductules. D. Immunostain for P63 is positive; CK7, CK20, chromogranin, synaptophysin, and TTF1 were negative | |||
{| | {| | ||
[[File:1 Met scc 1 680x512px.tif|Metastatic poorly differentiated neuroendocrine carcinoma of pulmonary origin.]] | [[File:1 Met scc 1 680x512px.tif|Metastatic poorly differentiated neuroendocrine carcinoma of pulmonary origin.]] | ||
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Metastatic thyroid carcinoma. A. Carcinoma with open spaces spares part of a normal liver lobule [arrow] (40X). B. A sheet with acini [arrows] would indicate only adenocarcinoma (400X). C. A true papilla with vascular spaces [arrows] suggests papillary carcinoma (400X). D. Some spaces show tumor nuclei with inclusions [arrows] (400X). E. Tumor nuclei are TTF1 positive, which can also be seen with lung cancer (IHC 400X). F. Specific thyroglobulin positivity rendered the specific diagnosis known (IHC 400X). | Metastatic thyroid carcinoma. A. Carcinoma with open spaces spares part of a normal liver lobule [arrow] (40X). B. A sheet with acini [arrows] would indicate only adenocarcinoma (400X). C. A true papilla with vascular spaces [arrows] suggests papillary carcinoma (400X). D. Some spaces show tumor nuclei with inclusions [arrows] (400X). E. Tumor nuclei are TTF1 positive, which can also be seen with lung cancer (IHC 400X). F. Specific thyroglobulin positivity rendered the specific diagnosis known (IHC 400X). | ||
[[File: RCC MET 1 sl 1.png| Metastasis of renal cell carcinoma to liver]] | |||
[[File: RCC MET 1 sl 2.png| Metastasis of renal cell carcinoma to liver]] | |||
[[File: RCC MET 1 sl 3.png| Metastasis of renal cell carcinoma to liver]] | |||
[[File: RCC MET 1 sl 4.png| Metastasis of renal cell carcinoma to liver]] | |||
[[File: RCC MET 1 sl 5.png| Metastasis of renal cell carcinoma to liver]] | |||
Metastasis of renal cell carcinoma to liver. A. Upper core shows blue necrosis; remainder shows replacement by tumor. B. In part cytoplasm is abundant and amphophilic, suggesting hepatocellular carcinoma. C. In part, tumor shows clear cytoplasm, raising alternative explanations. D. High power of clear area shows finely reticulated cytoplasm with sharp intercellular borders. Nuclei are bizarrely shaped, often with nucleoli. Arrow shows an aberrant mitosis. E. Immunostain for RCC proves renal cell carcinoma. | |||
===Melanoma=== | |||
{| | |||
[[File:1 Liv Met 2 680x512px.tif|Melanoma metastatic to liver.]] | |||
[[File:2 Liv Met 2 680x512px.tif|Melanoma metastatic to liver.]] | |||
<br> | |||
[[File:3 Liv Met 2 680x512px.tif|Melanoma metastatic to liver.]] | |||
[[File:4 Liv Met 2 680x512px.tif|Melanoma metastatic to liver.]] | |||
<br> | |||
[[File:5 Liv Met 2 680x512px.tif|Melanoma metastatic to liver.]] | |||
[[File:6 Liv Met 2 680x512px.tif|Melanoma metastatic to liver.]] | |||
|} | |||
Melanoma metastatic to liver. A. Low power contrasts normal preserved liver (arrow) with remaining mass of cancer [2x]. B. Necrosis on left abuts brown, pigmented cells on right [200X]. C. Apparent acini (green arrows), vacuoles (blue arrow), and papillae (black arrows) might lead to a wrong diagnosis [200X]. D. Apparent wall-like epithelial seeming lining (green arrows) and giant cells (blue arrows) might tempt a wrong diagnosis, which the pigment (black arrows) should discourage [400X]. E. Intranuclear inclusions (green arrow), eccentrically placed nuclei (blue arrows) and pigment (black arrows) suggest the proper diagnosis [400X]. F. MART 1 immunostain is positive in viable cancer cells [400X]. | |||
<pre> | <pre> | ||
Liver Lesion, Core Biopsy: | Liver Lesion, Core Biopsy: | ||