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Difference between revisions of "Liver metastasis"
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(Added a colon cancer met) |
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| LMDDx = primary liver lesions ([[cholangiocarcinoma]], [[hepatocellular carcinoma]] (esp. pseudoglandular), [[epithelioid hemangioendothelioma]]) | | LMDDx = primary liver lesions ([[cholangiocarcinoma]], [[hepatocellular carcinoma]] (esp. pseudoglandular), [[epithelioid hemangioendothelioma]]) | ||
| Stains = | | Stains = | ||
| IHC = HepPar-1 -ve, CK20 +ve (colorectal carcinoma) | | IHC = [[HepPar-1]] -ve, [[CK20]] +ve (colorectal carcinoma) | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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==IHC== | ==IHC== | ||
*Metastases are typically negative for ''HepPar-1''. | *Metastases are typically negative for ''HepPar-1''. | ||
**HepPar-1 (hepatocytes paraffin antibody 1) - labels hepatocellular mitochondria.<ref name=pmid12502967>The diagnostic value of hepatocyte paraffin antibody 1 in differentiating hepatocellular neoplasms from nonhepatic tumors: a review. Lamps LW, Folpe AL. Adv Anat Pathol. 2003 Jan;10(1):39-43. Review. PMID 12502967.</ref> | **[[HepPar-1]] (hepatocytes paraffin antibody 1) - labels hepatocellular mitochondria.<ref name=pmid12502967>The diagnostic value of hepatocyte paraffin antibody 1 in differentiating hepatocellular neoplasms from nonhepatic tumors: a review. Lamps LW, Folpe AL. Adv Anat Pathol. 2003 Jan;10(1):39-43. Review. PMID 12502967.</ref> | ||
A panel: | A panel: | ||
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Metastasis of colonic carcinoma to liver. A. Blue arrow shows colon cancer with large acini. Green arrow shows necrotic tumor. Black arrow shows sinusoidal dilatation, an example of a nonspecific tumor associated change that should not be deemed systemic in nature. B. Elongated nuclei perpendicular to acinar border (green arrows) and dirty luminal necrosis (black arrow) are characteristic of colon cancer. C. Immunostain for CK7. Positive groups may be focal staining by tumor, but more likely are residual bile ductules. D. Immunostain for CK20 is more diffusely positive and definitely in tumor. | Metastasis of colonic carcinoma to liver. A. Blue arrow shows colon cancer with large acini. Green arrow shows necrotic tumor. Black arrow shows sinusoidal dilatation, an example of a nonspecific tumor associated change that should not be deemed systemic in nature. B. Elongated nuclei perpendicular to acinar border (green arrows) and dirty luminal necrosis (black arrow) are characteristic of colon cancer. C. Immunostain for CK7. Positive groups may be focal staining by tumor, but more likely are residual bile ductules. D. Immunostain for CK20 is more diffusely positive and definitely in tumor. | ||
[[File: SQC MET 1 sl 1.png| Metastasis of squamous carcinoma to liver]] | |||
[[File: SQC MET 1 sl 2.png| Metastasis of squamous carcinoma to liver]] | |||
[[File: SQC MET 1 sl 3.png| Metastasis of squamous carcinoma to liver]] | |||
[[File: SQC MET 1 sl 4.png| Metastasis of squamous carcinoma to liver]] | |||
[[File: SQC MET 1 sl 5.png| Metastasis of squamous carcinoma to liver]] | |||
Metastasis of Squamous carcinoma to liver. A. Dark blue tumor groups mass to replace liver.B. Carcinomatous nests show scant stromal separation, with individual cancer cells being a the edge of the necrotic space C. Huge nucle show nucleoli with occasional spindleds cell nuclei. Individual cell necrosis is prominent. Cytoplasm is scant. Immunostain for CK7. Positive groups may be focal staining by tumor, but more likely are residual bile ductules. D. Immunostain for P63 is positive; CK7, CK20, chromogranin, synaptophysin, and TTF1 were negative | |||