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Neurodegenerative diseases (view source)
Revision as of 06:28, 24 October 2019
, 06:28, 24 October 2019→General: Prion strains
Jensflorian (talk | contribs) (→Common diseases: asyn -> Prion?) |
Jensflorian (talk | contribs) (→General: Prion strains) |
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*Misfolded cell-surface protein called PrP<sup>SC</sup>. | *Misfolded cell-surface protein called PrP<sup>SC</sup>. | ||
**This is derived from the protein ''PrP<sup>C</sup>'' encoded by the ''PRNP'' gene. | **This is derived from the protein ''PrP<sup>C</sup>'' encoded by the ''PRNP'' gene. | ||
*Different genetics strains are associated with varying clinical phenotype.<ref>{{Cite journal | last1 = Monari | first1 = L. | last2 = Chen | first2 = SG. | last3 = Brown | first3 = P. | last4 = Parchi | first4 = P. | last5 = Petersen | first5 = RB. | last6 = Mikol | first6 = J. | last7 = Gray | first7 = F. | last8 = Cortelli | first8 = P. | last9 = Montagna | first9 = P. | title = Fatal familial insomnia and familial Creutzfeldt-Jakob disease: different prion proteins determined by a DNA polymorphism. | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 7 | pages = 2839-42 | month = Mar | year = 1994 | doi = 10.1073/pnas.91.7.2839 | PMID = 7908444 }}</ref> | |||
Includes: | Includes: | ||