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Difference between revisions of "Histiocytoses"
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→Historical classification of histiocytoses in a table
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'''Histiocytoses''', singular '''histiocytosis''', are a rare set of conditions affecting tissue macrophages. | '''Histiocytoses''', singular '''histiocytosis''', are a rare set of conditions affecting tissue macrophages. | ||
== | ==Historical classification of histiocytoses in a table== | ||
Features of histiocytoses:<ref>{{Ref Sternberg4|479}}</ref> | Features of histiocytoses:<ref>{{Ref Sternberg4|479}}</ref> | ||
{| class="wikitable" border="1" | {| class="wikitable" border="1" | ||
| Line 7: | Line 7: | ||
! | ! | ||
! Histologic features | ! Histologic features | ||
! [[EM]] features | ! [[Electron microscopy|EM]] features | ||
! CD68 | ! CD68 | ||
! S-100 | ! S-100 | ||
| Line 47: | Line 47: | ||
Notes: | Notes: | ||
*''EM'' = [[electron microscopy]]. | *''EM'' = [[electron microscopy]]. | ||
The classification has evolved considerably, as the entities can overlap. An overview of a more recent classification is found in the article ''[[classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages]]''. | |||
==Langerhans cell histiocytosis== | ==Langerhans cell histiocytosis== | ||
{{Main|Langerhans cell histiocytosis}} | {{Main|Langerhans cell histiocytosis}} | ||
===IHC=== | ===IHC=== | ||
Langerin (CD207).<ref> | Langerin (CD207).<ref name=omim604862>{{OMIM|604862}}</ref> | ||
==Erdheim-Chester disease== | ==Erdheim-Chester disease== | ||
| Line 57: | Line 59: | ||
===General=== | ===General=== | ||
*Rare. | *Rare. | ||
* | *Clonal proliferation of histiocytes; 3 of 5 cases shown monoclonal by Chetritt ''el al''.<ref name=pmid10492045>{{Cite journal | last1 = Chetritt | first1 = J. | last2 = Paradis | first2 = V. | last3 = Dargere | first3 = D. | last4 = Adle-Biassette | first4 = H. | last5 = Maurage | first5 = CA. | last6 = Mussini | first6 = JM. | last7 = Vital | first7 = A. | last8 = Wechsler | first8 = J. | last9 = Bedossa | first9 = P. | title = Chester-Erdheim disease: a neoplastic disorder. | journal = Hum Pathol | volume = 30 | issue = 9 | pages = 1093-6 | month = Sep | year = 1999 | doi = 10.1016/s0046-8177(99)90228-9 | PMID = 10492045 }}</ref> | ||
===Gross=== | ===Gross=== | ||
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*Bone involvement - classic. | *Bone involvement - classic. | ||
*Usually multiple systems are involved. | *Usually multiple systems are involved. | ||
Note: | |||
*Does ''not'' usually involve the lymph nodes - like [[Rosai-Dorfman disease]]. | |||
===Microscopic=== | ===Microscopic=== | ||
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*[[Langerhans cell histiocytosis]]. | *[[Langerhans cell histiocytosis]]. | ||
Images: | ====Images==== | ||
<gallery> | |||
Image: Maladie de Chester-Erdheim.png |EHC. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770491/figure/f1/ ECD (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770491/figure/f1/ ECD (nih.gov)]. | ||
| Line 89: | Line 98: | ||
*[[Neuropathology]]. | *[[Neuropathology]]. | ||
*[[Hemophagocytic syndrome]]. | *[[Hemophagocytic syndrome]]. | ||
*[[Histiocytic sarcoma]]. | |||
==References== | ==References== | ||
{{reflist| | {{reflist|2}} | ||
[[Category:Weird stuff]] | [[Category:Weird stuff]] | ||