Small bowel pseudomelanosis: Difference between revisions
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Small bowel pseudomelanosis - alt -- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Small bowel pseudomelanosis. [[H&E stain]]. | ||
| Synonyms = pseudomelanosis duodeni (for [[duodenum]]) | | Synonyms = pseudomelanosis duodeni (for [[duodenum]]) | ||
| Micro = dark pigment in the lamina propria macrophages | | Micro = dark pigment in the lamina propria macrophages | ||
| Line 42: | Line 42: | ||
</ref> | </ref> | ||
Associations:<ref name=pmid18253910/> | Associations in a series of 17 individuals:<ref name=pmid18253910/> | ||
*[[Hypertension]] ~90% of cases. | *[[Hypertension]] ~90% of cases. | ||
*Iron supplementation ~75% of cases. | *Iron supplementation ~75% of cases. | ||
| Line 57: | Line 57: | ||
*Dark pigment in the lamina propria macrophages. | *Dark pigment in the lamina propria macrophages. | ||
Images: | ===Images=== | ||
====Case 1==== | |||
<gallery> | |||
Image: Small bowel pseudomelanosis -- low mag.jpg | SBP - low mag. (WC/Nephron) | |||
Image: Small bowel pseudomelanosis -- intermed mag.jpg | SBP - intermed. mag. (WC/Nephron) | |||
Image: Small bowel pseudomelanosis - alt -- intermed mag.jpg | SBP - intermed. mag. (WC/Nephron) | |||
Image: Small bowel pseudomelanosis -- high mag.jpg | SBP - high mag. (WC/Nephron) | |||
Image: Small bowel pseudomelanosis -- very high mag.jpg | SBP - very high mag. (WC/Nephron) | |||
Image: Small bowel pseudomelanosis - iron -- intermed mag.jpg | SBP - intermed. mag. (WC/Nephron) | |||
Image: Small bowel pseudomelanosis - iron -- high mag.jpg | SBP - high mag. (WC/Nephron) | |||
</gallery> | |||
====Case 2==== | |||
<gallery> | |||
Image: Pseudomelanosis ileum -- very low mag.jpg | PI - very low mag. (WC) | |||
Image: Pseudomelanosis ileum -- low mag.jpg | PI - low mag. (WC) | |||
Image: Pseudomelanosis ileum -- intermed mag.jpg | PI - intermed. mag. (WC) | |||
Image: Pseudomelanosis ileum -- high mag.jpg | PI - high mag. (WC) | |||
Image: Pseudomelanosis ileum - alt -- high mag.jpg | PI - high mag. (WC) | |||
Image: Pseudomelanosis ileum -- very high mag.jpg | PI - very high mag. (WC) | |||
</gallery> | |||
====www==== | |||
*[http://path.upmc.edu/cases/case616.html Pseudomelanosis duodeni - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case616.html Pseudomelanosis duodeni - several images (upmc.edu)]. | ||
| Line 77: | Line 98: | ||
Comment: | Comment: | ||
Pseudomelanosis may be seen in the context of iron supplementation, hypertension | Pseudomelanosis may be seen in the context of iron supplementation, hypertension | ||
or chronic renal failure. | |||
The macrophages are positive with an iron stain. | The macrophages are positive with an iron stain. | ||
</pre> | |||
===Duodenum=== | |||
<pre> | |||
Duodenum, Biopsy: | |||
- Small bowel mucosa with pseudomelanosis, otherwise within | |||
normal limits, see comment. | |||
Comment: | |||
Pseudomelanosis of the duodenum (pseudomelanosis duodeni) may be seen in the context of iron supplementation, hypertension or chronic renal failure. Endoscopically, it may manifest as dark spots. | |||
The pigmented cells are POSITIVE with an iron stain, NEGATIVE with a PAS stain and NEGATIVE with a Fontana-Masson stain; these findings are in keeping pseudomelanosis duodeni. | |||
</pre> | </pre> | ||
==See also== | ==See also== | ||
*[[Pseudomelanosis coli]]. | *[[Pseudomelanosis coli]]. | ||
*[[Melanocytic lesions]]. | |||
==References== | ==References== | ||