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Difference between revisions of "Sarcomatoid urothelial carcinoma"
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Sarcomatoid urothelial carcinoma (view source)
Revision as of 13:47, 18 April 2019
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| Micro = | | Micro = | ||
| Subtypes = (subtype of [[urothelial carcinoma]]) | | Subtypes = (subtype of [[urothelial carcinoma]]) | ||
| LMDDx = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas | | LMDDx = [[sarcoma]], [[carcinosarcoma]] - esp. in women, other sarcomatoid carcinomas, [[collision tumour]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = GATA3 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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==General== | ==General== | ||
*Rare.<ref name= | *Rare<ref name=pmid26068625/> approximately 0.1% of bladder carcinomas - based on the SEER database in the time span 1973-2004.<ref name=pmid20706685>{{Cite journal | last1 = Wang | first1 = J. | last2 = Wang | first2 = FW. | last3 = Lagrange | first3 = CA. | last4 = Hemstreet Iii | first4 = GP. | last5 = Kessinger | first5 = A. | title = Clinical features of sarcomatoid carcinoma (carcinosarcoma) of the urinary bladder: analysis of 221 cases. | journal = Sarcoma | volume = 2010 | issue = | pages = | month = | year = 2010 | doi = 10.1155/2010/454792 | PMID = 20706685 }}</ref> | ||
*Aggressive >55% dead within one year of presentation.<ref name=pmid26068625/> | *Aggressive >55% dead within one year of presentation.<ref name=pmid26068625/> | ||
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DDx: | DDx: | ||
*[[Sarcoma]] - esp. those arising from the retroperitoneum. | *[[Sarcoma]] - esp. those arising from the retroperitoneum. | ||
*[[Carcinosarcoma]] - esp. in women. | |||
*Other [[sarcomatoid carcinoma]]s, e.g. [[sarcomatoid prostate carcinoma]]. | |||
*[[Collision tumour]] (rare) - components should ''not'' intermingle. | |||
===Images=== | ===Images=== | ||
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Image: Urothelial carcinoma with sarcomatoid differentiation -- high mag.jpg | Sarcomatoid UCC - high mag. | Image: Urothelial carcinoma with sarcomatoid differentiation -- high mag.jpg | Sarcomatoid UCC - high mag. | ||
</gallery> | </gallery> | ||
==IHC== | |||
*GATA3 +ve (16 +ve of 22 cases<ref name=pmid24824028>{{Cite journal | last1 = Fatima | first1 = N. | last2 = Osunkoya | first2 = AO. | title = GATA3 expression in sarcomatoid urothelial carcinoma of the bladder. | journal = Hum Pathol | volume = 45 | issue = 8 | pages = 1625-9 | month = Aug | year = 2014 | doi = 10.1016/j.humpath.2014.03.015 | PMID = 24824028 }}</ref>). | |||
==See also== | ==See also== | ||