Neuroblastoma: Difference between revisions
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Jensflorian (talk | contribs) →Classification/grading: INRGSS |
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Laboratory findings: | Laboratory findings: | ||
*Increased urine homovanillic acid. | *Increased urine homovanillic acid. | ||
Imaging: | |||
*mIBG uptake (>90% neuroblastomas) | |||
Predictors of a poor prognosis:<ref name=Ref_PCPBoD8_254>{{Ref PCPBoD8|254}}</ref> | Predictors of a poor prognosis:<ref name=Ref_PCPBoD8_254>{{Ref PCPBoD8|254}}</ref> | ||
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*Near ploidy. | *Near ploidy. | ||
*N-MYC amplification. | *N-MYC amplification. | ||
*1p deletion /imbalance | |||
*Lymph node spread. | *Lymph node spread. | ||
*Distant spread. | *Distant spread. | ||
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*Molecular abnormalities. | *Molecular abnormalities. | ||
International Neuroblastoma Risk Group Staging System (INRGSS) | |||
* L1: Locoregional tumor without Image-Definging Risk factors (IDRFs) | |||
* L2: Locoregional tumor with one or more IDRFs | |||
* M: Distant metastatic disease (except Ms) | |||
* Ms: INRG Stage L1 or L2 tumor with metastatic disease confined to skin and/or liver and/or bone marrow and age below 18 months. | |||
==IHC== | |||
*PGP 9.5 +ve.<ref>{{Cite journal | last1 = Ootsuka | first1 = S. | last2 = Asami | first2 = S. | last3 = Sasaki | first3 = T. | last4 = Yoshida | first4 = Y. | last5 = Nemoto | first5 = N. | last6 = Shichino | first6 = H. | last7 = Chin | first7 = M. | last8 = Mugishima | first8 = H. | last9 = Suzuki | first9 = T. | title = Useful markers for detecting minimal residual disease in cases of neuroblastoma. | journal = Biol Pharm Bull | volume = 31 | issue = 6 | pages = 1071-4 | month = Jun | year = 2008 | doi = | PMID = 18520032 }}</ref> | *PGP 9.5 +ve.<ref>{{Cite journal | last1 = Ootsuka | first1 = S. | last2 = Asami | first2 = S. | last3 = Sasaki | first3 = T. | last4 = Yoshida | first4 = Y. | last5 = Nemoto | first5 = N. | last6 = Shichino | first6 = H. | last7 = Chin | first7 = M. | last8 = Mugishima | first8 = H. | last9 = Suzuki | first9 = T. | title = Useful markers for detecting minimal residual disease in cases of neuroblastoma. | journal = Biol Pharm Bull | volume = 31 | issue = 6 | pages = 1071-4 | month = Jun | year = 2008 | doi = | PMID = 18520032 }}</ref> | ||
**PGP = protein gene product. | **PGP = protein gene product. | ||