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Difference between revisions of "Disordered proliferative endometrium"
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Disordered proliferative endometrium (view source)
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Disordered proliferative endometrium -- low mag.jpg | |||
| Width = | |||
| Caption = Disordered proliferative endometrium. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = proliferative endometrial glands (pseudostratified nuclei + mitoses) with focally abnormal glands (glands >2x normal size; irregular shape -- typically with inflection points; >4 glands involved (dilated)), +/-stromal condensation, gland-to-stromal ratio normal, not within an endometrial polyp | |||
| Subtypes = | |||
| LMDDx = [[proliferative phase endometrium]],[[simple endometrial hyperplasia]], [[benign endometrial polyp]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[endometrium]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = followup - re-biopsy | |||
}} | |||
'''Disordered proliferative endometrium''', abbreviated '''DPE''', is an abnormal [[endometrium|endometrial]] finding with some features of [[simple endometrial hyperplasia]]. | '''Disordered proliferative endometrium''', abbreviated '''DPE''', is an abnormal [[endometrium|endometrial]] finding with some features of [[simple endometrial hyperplasia]]. | ||
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Image: | Image: | ||
*[http://www.jabfm.org/content/19/6/590/F8.expansion.html Treatment | *[http://www.jabfm.org/content/19/6/590/F8.expansion.html Treatment algorithm based on endometrial biopsy results (jabfm.org)].<ref name=pmid17090792/> | ||
==Microscopic== | ==Microscopic== | ||
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***Glands >2x normal size - usually 3-4x normal. | ***Glands >2x normal size - usually 3-4x normal. | ||
***Irregular shape, e.g. gland contour has inflection points. | ***Irregular shape, e.g. gland contour has inflection points. | ||
***Greater than | ***Greater than four glands involved (dilated). | ||
*+/-Stromal condensation -- balls of stromal tissue, aka "blue balls" (due to breakdown of endometrium). | *+/-Stromal condensation -- balls of stromal tissue, aka "blue balls" (due to breakdown of endometrium). | ||
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**Stroma: cellular, stroma (spindle cells), mitoses. | **Stroma: cellular, stroma (spindle cells), mitoses. | ||
*[[Simple endometrial hyperplasia]] without atypia - architectural atypia diffuse. | *[[Simple endometrial hyperplasia]] without atypia - architectural atypia diffuse. | ||
*[[Benign endometrial polyp]]. | *[[Benign endometrial polyp]] - may have gland dilation. | ||
*[[Anovulatory endometrium]] - some consider this a synonym, see ''[[relation to disordered proliferative endometrium]]''. | |||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Disordered proliferative endometrium -- low mag.jpg | DPE - low mag. | |||
Image: Disordered proliferative endometrium -- intermed mag.jpg | DPE - intermed. mag. | |||
Image: Disordered proliferative endometrium - alt -- intermed mag.jpg | DPE - intermed. mag. | |||
Image: Disordered proliferative endometrium -- high mag.jpg | DPE - high mag. | |||
Image: Disordered proliferative endometrium - alt -- high mag.jpg | DPE - high mag. | |||
</gallery> | |||
<gallery> | |||
Image:Endometrial_stromal_condensation_high_mag.jpg | Endometrial stromal condensation - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | www: | ||
*[http://www.sciencedirect.com/science/article/pii/S0740257010000997#fig15 DPE (sciencedirect.com)]. | *[http://www.sciencedirect.com/science/article/pii/S0740257010000997#fig15 DPE (sciencedirect.com)]. | ||
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*[http://www.glowm.com/resources/glowm/uploads/1225247516_03-50291-007_small.jpg DPE (glowm.com)].<ref name=glowm>URL: [http://www.glowm.com/index.html?p=glowm.cml/section_view&articleid=235 http://www.glowm.com/index.html?p=glowm.cml/section_view&articleid=235]. Accessed on: 11 December 2012.</ref> | *[http://www.glowm.com/resources/glowm/uploads/1225247516_03-50291-007_small.jpg DPE (glowm.com)].<ref name=glowm>URL: [http://www.glowm.com/index.html?p=glowm.cml/section_view&articleid=235 http://www.glowm.com/index.html?p=glowm.cml/section_view&articleid=235]. Accessed on: 11 December 2012.</ref> | ||
*[http://www.hsc.stonybrook.edu/gyn-atlas/UT3431B.htm DPE (stonybrook.edu)]. | *[http://www.hsc.stonybrook.edu/gyn-atlas/UT3431B.htm DPE (stonybrook.edu)]. | ||
==Sign out== | ==Sign out== | ||