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Secretory phase endometrium (view source)
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'''Secretory phase endometrium''', abbreviated '''SPE''', is a common diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Secretory phase endometrium -- intermed mag.jpg | |||
| Width = | |||
| Caption = Secretory phase. [[H&E stain]]. | |||
| Micro = dependent on day post-ovulation - see microscopic | |||
| Subtypes = | |||
| LMDDx = [[endometrial hyperplasia with secretory changes]], [[endometrium with hormonal changes]],[[proliferative phase endometrium]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[endometrium]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = normal finding | |||
| ClinDDx = | |||
}} | |||
'''Secretory phase endometrium''', abbreviated '''SPE''', is a common diagnosis in [[endometrium|endometrial]] specimens. | |||
==General== | ==General== | ||
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===Premenstrual=== | ===Premenstrual=== | ||
*Stroma: [[neutrophil]]s, scattered lymphocytes, stromal balls ("blue balls"); "stromal condensation". | *Stroma: [[neutrophil]]s, scattered lymphocytes, stromal balls ("blue balls"); "stromal condensation". | ||
*Glands: [[apoptosis]] at the base of the gland.<ref> | *Glands: [[apoptosis]] at the base of the gland.<ref>Colgan T. 22 June 2009.</ref> | ||
Notes: | Notes: | ||
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*[[Proliferative phase endometrium]] - may have some changes of secretory endometrium; <50% of glands have subnuclear vacuoles ''or'' <50% of cells in the glands have subnuclear vacuoles.<ref name=Ref_EMB14>{{Ref EMB|14}}</ref> | *[[Proliferative phase endometrium]] - may have some changes of secretory endometrium; <50% of glands have subnuclear vacuoles ''or'' <50% of cells in the glands have subnuclear vacuoles.<ref name=Ref_EMB14>{{Ref EMB|14}}</ref> | ||
Image: | ===Images=== | ||
<gallery> | |||
Image: Early secretory phase endometrium -- intermed mag.jpg | Early SPE - intermed. mag. (WC) | |||
Image: Early secretory phase endometrium -- high mag.jpg | Early SPE - high mag. (WC) | |||
Image: Early secretory phase endometrium -- very high mag.jpg | Early SPE - very high mag. (WC) | |||
</gallery> | |||
<gallery> | |||
Image: Secretory phase endometrium -- low mag.jpg | Late SPE - low mag. (WC) | |||
Image: Secretory phase endometrium -- intermed mag.jpg | Late SPE - intermed. mag. (WC) | |||
Image: Secretory phase endometrium -- high mag.jpg | Late SPE - high mag. (WC) | |||
</gallery> | |||
<gallery> | <gallery> | ||
Image:Endometrium_Secretory-Type_Endometrium_10x1.JPG | Early secretory phase endometrium. (WC) | Image:Endometrium_Secretory-Type_Endometrium_10x1.JPG | Early secretory phase endometrium. (WC) | ||
Image:Endometrium_Secretory_20x1.jpg | Early secretory phase endometrium. (WC) | |||
Image:Endometrial_stromal_condensation_high_mag.jpg | Endometrial stromal condensation. (WC/Nephron) | Image:Endometrial_stromal_condensation_high_mag.jpg | Endometrial stromal condensation. (WC/Nephron) | ||
</gallery> | </gallery> | ||
==Sign out== | |||
<pre> | <pre> | ||
ENDOMETRIUM, BIOPSY: | ENDOMETRIUM, BIOPSY: | ||
- SECRETORY PHASE ENDOMETRIUM. | |||
</pre> | |||
<pre> | |||
ENDOMETRIUM, ASPIRATION: | |||
- SECRETORY PHASE ENDOMETRIUM. | - SECRETORY PHASE ENDOMETRIUM. | ||
</pre> | </pre> | ||
| Line 68: | Line 113: | ||
- SECRETORY PHASE ENDOMETRIUM, EARLY. | - SECRETORY PHASE ENDOMETRIUM, EARLY. | ||
</pre> | </pre> | ||
===With additional stuff=== | |||
<pre> | <pre> | ||
ENDOMETRIUM, BIOPSY: | ENDOMETRIUM, BIOPSY: | ||
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</pre> | </pre> | ||
====Micro | ===Evidence of shedding=== | ||
The sections show endometrium with a normal gland-to-stroma ratio. | <pre> | ||
ENDOMETRIUM, CURETTAGE: | |||
- SECRETORY PHASE ENDOMETRIUM WITH FINDINGS SUGGESTIVE OF SHEDDING (EPITHELIAL | |||
APOPTOSIS, INFLAMMATORY CELLS - ESPECIALLY NEUTROPHILS). | |||
- BENIGN EXOCERVICAL AND ENDOCERVICAL MUCOSA. | |||
</pre> | |||
===Micro=== | |||
The sections show endometrium with a normal gland-to-stroma ratio. The glands are mildly dilated, tortuous and have mucus within them. The glandular epithelium is simple and non-pseudostratified. The stroma is edematous and has a decidual reaction. No mitotic activity is apparent. | |||
==See also== | ==See also== | ||