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Difference between revisions of "Embryonal tumour with multilayered rosettes"
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Embryonal tumour with multilayered rosettes (view source)
Revision as of 09:09, 23 January 2019
, 09:09, 23 January 2019→IHC: molecular update
Jensflorian (talk | contribs) m (WHO) |
Jensflorian (talk | contribs) (→IHC: molecular update) |
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File:Neuroblasts ependymoblastoma.jpg | ETMR, ganglion cells. | File:Neuroblasts ependymoblastoma.jpg | ETMR, ganglion cells. | ||
</gallery> | </gallery> | ||
DDx: | |||
*[[AT/RT]]. | |||
*[[Medulloblastoma]]. | |||
*[[Ependymoma]]. | |||
* CNS embryonal tumor, NOS. | |||
* Pediatric [[glioblastoma]]. | |||
==IHC== | ==IHC== | ||
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File:MIB1 ependymoblastoma.jpg | MIB1 in ETMR rosettes. | File:MIB1 ependymoblastoma.jpg | MIB1 in ETMR rosettes. | ||
</gallery> | </gallery> | ||
==Molecular== | |||
*Chr 2 gain. | |||
*C19MC amplification. <ref>{{Cite journal | last1 = Spence | first1 = T. | last2 = Sin-Chan | first2 = P. | last3 = Picard | first3 = D. | last4 = Barszczyk | first4 = M. | last5 = Hoss | first5 = K. | last6 = Lu | first6 = M. | last7 = Kim | first7 = SK. | last8 = Ra | first8 = YS. | last9 = Nakamura | first9 = H. | title = CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity. | journal = Acta Neuropathol | volume = 128 | issue = 2 | pages = 291-303 | month = Aug | year = 2014 | doi = 10.1007/s00401-014-1291-1 | PMID = 24839957 }}</ref> | |||
*Some rare LIN28+ve cases without C19MC amplification may show DICER1 mutations.<ref>{{Cite journal | last1 = Uro-Coste | first1 = E. | last2 = Masliah-Planchon | first2 = J. | last3 = Siegfried | first3 = A. | last4 = Blanluet | first4 = M. | last5 = Lambo | first5 = S. | last6 = Kool | first6 = M. | last7 = Roujeau | first7 = T. | last8 = Boetto | first8 = S. | last9 = Palenzuela | first9 = G. | title = ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors. | journal = Acta Neuropathol | volume = 137 | issue = 1 | pages = 175-177 | month = Jan | year = 2019 | doi = 10.1007/s00401-018-1935-7 | PMID = 30446821 }}</ref> | |||
==See also== | ==See also== | ||
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[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology]] | [[Category:Neuropathology tumours]] | ||