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Difference between revisions of "Sunitinib"
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'''Sunitinib''' (marketed with the brand name ''Sutent'') is a [[tyrosine kinase inhibitor]] used to treat [[renal cell carcinoma]] (RCC). | '''Sunitinib''' (marketed with the brand name ''Sutent'' by Pfizer) is a [[tyrosine kinase inhibitor]] used to treat [[renal cell carcinoma]] (RCC). | ||
In RCC acts on:<ref>{{Cite journal | last1 = Toon | first1 = CW. | last2 = Hasovits | first2 = C. | last3 = Paik | first3 = J. | last4 = Field | first4 = M. | last5 = Chou | first5 = A. | last6 = Hugh | first6 = TJ. | last7 = Pavlakis | first7 = N. | last8 = Gill | first8 = AJ. | title = Skin rash, a kidney mass and a family mystery dating back to World War II. | journal = Med J Aust | volume = 201 | issue = 1 | pages = 58-60 | month = Jul | year = 2014 | doi = | PMID = 24999901 }}</ref> | In RCC acts on:<ref>{{Cite journal | last1 = Toon | first1 = CW. | last2 = Hasovits | first2 = C. | last3 = Paik | first3 = J. | last4 = Field | first4 = M. | last5 = Chou | first5 = A. | last6 = Hugh | first6 = TJ. | last7 = Pavlakis | first7 = N. | last8 = Gill | first8 = AJ. | title = Skin rash, a kidney mass and a family mystery dating back to World War II. | journal = Med J Aust | volume = 201 | issue = 1 | pages = 58-60 | month = Jul | year = 2014 | doi = | PMID = 24999901 }}</ref> | ||
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*PDGFbeta. | *PDGFbeta. | ||
== | ==Uses== | ||
*[[Gastrointestinal stromal tumour]], imatinib-resistant.<ref>{{Cite journal | last1 = Mulet-Margalef | first1 = N. | last2 = Garcia-Del-Muro | first2 = X. | title = Sunitinib in the treatment of gastrointestinal stromal tumor: patient selection and perspectives. | journal = Onco Targets Ther | volume = 9 | issue = | pages = 7573-7582 | month = | year = 2016 | doi = 10.2147/OTT.S101385 | PMID = 28008275 }}</ref> | *[[Gastrointestinal stromal tumour]], imatinib-resistant.<ref>{{Cite journal | last1 = Mulet-Margalef | first1 = N. | last2 = Garcia-Del-Muro | first2 = X. | title = Sunitinib in the treatment of gastrointestinal stromal tumor: patient selection and perspectives. | journal = Onco Targets Ther | volume = 9 | issue = | pages = 7573-7582 | month = | year = 2016 | doi = 10.2147/OTT.S101385 | PMID = 28008275 }}</ref> | ||
*[[Renal cell carcinoma]] - especially [[clear cell renal cell carcinoma]].<ref name=pmid25075067>{{Cite journal | last1 = Yildiz | first1 = I. | last2 = Ekenel | first2 = M. | last3 = Akman | first3 = T. | last4 = Kocar | first4 = M. | last5 = Uysal | first5 = M. | last6 = Kanitez | first6 = M. | last7 = Varol | first7 = U. | last8 = Bayoglu | first8 = IV. | last9 = Tural | first9 = D. | title = Sunitinib for patients with metastatic non-clear cell renal cell carcinoma: a Multicenter Retrospective Turkish Oncology Group trial. | journal = Anticancer Res | volume = 34 | issue = 8 | pages = 4329-34 | month = Aug | year = 2014 | doi = | PMID = 25075067 }}</ref> | *[[Renal cell carcinoma]] - especially [[clear cell renal cell carcinoma]].<ref name=pmid25075067>{{Cite journal | last1 = Yildiz | first1 = I. | last2 = Ekenel | first2 = M. | last3 = Akman | first3 = T. | last4 = Kocar | first4 = M. | last5 = Uysal | first5 = M. | last6 = Kanitez | first6 = M. | last7 = Varol | first7 = U. | last8 = Bayoglu | first8 = IV. | last9 = Tural | first9 = D. | title = Sunitinib for patients with metastatic non-clear cell renal cell carcinoma: a Multicenter Retrospective Turkish Oncology Group trial. | journal = Anticancer Res | volume = 34 | issue = 8 | pages = 4329-34 | month = Aug | year = 2014 | doi = | PMID = 25075067 }}</ref> | ||