Penile intraepithelial neoplasia: Difference between revisions
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==Microscopic== | ==Microscopic== | ||
Subclassified | Subclassified as:<ref name=pmid22641959>{{Cite journal | last1 = Velazquez | first1 = EF. | last2 = Chaux | first2 = A. | last3 = Cubilla | first3 = AL. | title = Histologic classification of penile intraepithelial neoplasia. | journal = Semin Diagn Pathol | volume = 29 | issue = 2 | pages = 96-102 | month = May | year = 2012 | doi = | PMID = 22641959 }}</ref> | ||
*Undifferentiated PeIN (uPeIN). | *Undifferentiated PeIN (uPeIN). | ||
*Differentiated PeIN (dPeIN). | *Differentiated PeIN (dPeIN). | ||
Note: | |||
*Subclassification similar to one for [[vulvar intraepithelial neoplasia]], that is based on the role of [[HPV]] in the pathogenesis. | |||
===Undifferentiated penile intraepithelial neoplasia=== | ===Undifferentiated penile intraepithelial neoplasia=== | ||
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==IHC== | ==IHC== | ||
*p16 -ve in dPeIN,<ref>{{Cite journal | last1 = Oertell | first1 = J. | last2 = Caballero | first2 = C. | last3 = Iglesias | first3 = M. | last4 = Chaux | first4 = A. | last5 = Amat | first5 = L. | last6 = Ayala | first6 = E. | last7 = Rodríguez | first7 = I. | last8 = Velázquez | first8 = EF. | last9 = Barreto | first9 = JE. | title = Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence. | journal = Histopathology | volume = 58 | issue = 6 | pages = 925-33 | month = May | year = 2011 | doi = 10.1111/j.1365-2559.2011.03816.x | PMID = 21585428 }}</ref> +ve in uPeIN. | *p16 -ve in dPeIN,<ref>{{Cite journal | last1 = Oertell | first1 = J. | last2 = Caballero | first2 = C. | last3 = Iglesias | first3 = M. | last4 = Chaux | first4 = A. | last5 = Amat | first5 = L. | last6 = Ayala | first6 = E. | last7 = Rodríguez | first7 = I. | last8 = Velázquez | first8 = EF. | last9 = Barreto | first9 = JE. | title = Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence. | journal = Histopathology | volume = 58 | issue = 6 | pages = 925-33 | month = May | year = 2011 | doi = 10.1111/j.1365-2559.2011.03816.x | PMID = 21585428 }}</ref> +ve in uPeIN. | ||
==Sign out== | |||
<pre> | |||
Skin, Penile Lesion, Excision: | |||
- High-grade penile intraepithelial neoplasia (PeIN), undifferentiated type. | |||
-- Margin POSITIVE for PeIN. | |||
</pre> | |||
==See also== | ==See also== | ||