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Follicular thyroid carcinoma (view source)
Revision as of 09:25, 11 September 2018
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Follicular thyroid carcinoma 2 - alt -- low mag.jpg | |||
| Width = | |||
| Caption = [[Micrograph]] showing a follicular thyroid carcinoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = bland thyroid cells invading through the (fibrous) capsule or lymphovascular invasion or distal metastases | |||
| Subtypes = | |||
| LMDDx = [[follicular thyroid adenoma]], [[papillary thyroid carcinoma follicular variant]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[thyroid gland]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = thyroid nodule/mass | |||
| Symptoms = | |||
| Prevalence = uncommon, female predominant | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = good | |||
| Other = | |||
| ClinDDx = | |||
| Tx = surgical excision | |||
}} | |||
'''Follicular thyroid carcinoma''', abbreviated '''FTC''', is an uncommon malignancy of the [[thyroid gland]]. It is also known as ''follicular carcinoma''. | |||
==General== | |||
*Usually spread by the hematologic route. | |||
**PTC usually spreads via lymphatics. | |||
===Clinical=== | |||
Medical school memory device ''4 Fs'': | |||
*FNA NOT diagnosable. | |||
*Far away mets (sometimes). | |||
*Female predominant. | |||
*Favourable prognosis. | |||
==Gross== | |||
*Encapuslated lesion +/-evidence of invasion through the capsule. | |||
===Images=== | |||
<gallery> | |||
Image: Follicular adenoma of the thyroid.jpg | FTC - gross. (WC/Euthman) | |||
</gallery> | |||
==Microscopic== | |||
Features: | |||
*Defined by either: | |||
*#Invasion through the capsule: | |||
*#*Should be all the way through.<ref>SR. 17 January 2011.</ref> | |||
*#**1/2 does not count. | |||
*#**Fibrous reaction does not count. | |||
*#**"Above the contour" does not count. | |||
*#Vascular invasion (all of the following): | |||
*##In a small vein (not a capillary), that is outside of the tumour mass. | |||
*##Tumour adherent to the side of the vessel. | |||
*##Tumour must be re-endothelialized. | |||
Notes: | |||
*'''Impossible''' to differentiate from ''[[follicular thyroid adenoma|follicular adenoma]]'' on FNA (no cytologic differences). | |||
*Described as "over-diagnosed" ... misdiagnoses: PTC follicular variant, follicular adenoma, multinodular goitre with a thick capsule. | |||
DDx:<ref name=pmid21455197>{{Cite journal | last1 = Sobrinho-Simões | first1 = M. | last2 = Eloy | first2 = C. | last3 = Magalhães | first3 = J. | last4 = Lobo | first4 = C. | last5 = Amaro | first5 = T. | title = Follicular thyroid carcinoma. | journal = Mod Pathol | volume = 24 Suppl 2 | issue = | pages = S10-8 | month = Apr | year = 2011 | doi = 10.1038/modpathol.2010.133 | PMID = 21455197 }}</ref> | |||
*[[Follicular thyroid adenoma]]. | |||
*[[Papillary thyroid carcinoma follicular variant]]. | |||
*[[Poorly differentiated thyroid carcinoma]]. | |||
===Images=== | |||
<gallery> | |||
Follicular thyroid carcinoma -- very low mag.jpg | FTC - very low mag. | |||
Follicular thyroid carcinoma -- low mag.jpg | FTC - low mag. | |||
Follicular thyroid carcinoma -- intermed mag.jpg | FTC - intermed. mag. | |||
Follicular thyroid carcinoma -- high mag.jpg | FTC - high mag. | |||
Follicular thyroid carcinoma - alt -- high mag.jpg | FTC - high mag. | |||
Follicular thyroid carcinoma 2 -- very low mag.jpg | FTC - very low mag. | |||
Follicular thyroid carcinoma 2 -- low mag.jpg | FTC - low mag. | |||
Follicular thyroid carcinoma 2 - alt -- low mag.jpg | FTC - low mag. | |||
Follicular thyroid carcinoma 2 -- intermed mag.jpg | FTC - intermed. mag. | |||
Follicular thyroid carcinoma 2 - alt -- intermed mag.jpg | FTC - intermed. mag. | |||
Follicular thyroid carcinoma 2 -- high mag.jpg | FTC - high mag. | |||
</gallery> | |||
<gallery> | |||
Image:Metastatic_follicular_thyroid_carcinoma_-_Case_264_(8559837390).jpg | Metastatic FTC. (WC/Yale Rosen) | |||
Image:Metastatic_follicular_thyroid_carcinoma_-_Case_264_(8558730243).jpg | Metastatic FTC. (WC/Yale Rosen) | |||
</gallery> | |||
====www==== | |||
*[http://path.upmc.edu/cases/case653.html Follicular thyroid carcinoma - several images (upmc.edu)]. | |||
==See also== | |||
*[[Thyroid gland]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Thyroid gland]] | |||