Giant cells: Difference between revisions
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[[Image:Giant cell in bronchial wash -- very high mag.jpg|thumb|right|Giant cell from a [[pulmonary cytopathology|bronchial wash]]. [[Pap stain]].]] | |||
'''Giant cells''' are "big" cells with multiple nuclei. They come in different flavours, which are suggestive of causality. | '''Giant cells''' are "big" cells with multiple nuclei. They come in different flavours, which are suggestive of causality. | ||
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| Touton giant cell | | Touton giant cell | ||
| | | Nuclei form a ring around the cell periphery with eosinophilic cytoplasm centrally and foamy cytoplasm at the periphery. | ||
| [[ | | [[Juvenile xanthogranuloma]], [[xanthoma]], [[Erdheim-Chester disease]], [[fat necrosis]], [[dermatofibroma]] | ||
| | | High lipid content lesions<ref>URL: [http://granuloma.homestead.com/giant_cells.html http://granuloma.homestead.com/giant_cells.html]. Accessed on: 7 February 2011.</ref>, Named after Karl Touton | ||
| [[Image:Juvenile_xanthogranuloma_-_very_high_mag.jpg|thumb|200px|JXG (WC)]] | | [[Image:Juvenile_xanthogranuloma_-_very_high_mag.jpg|thumb|200px|JXG (WC)]] | ||
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| Langhans giant cell | | Langhans giant cell | ||
| peripheral eccentric nuclei<ref name=Ref_InstantPath7>{{Ref InstantPath|7}}</ref> | | peripheral semi-circular eccentric nuclei<ref name=Ref_InstantPath7>{{Ref InstantPath|7}}</ref> | ||
| | | tuberculosis, sarcoidosis. | ||
| '''not''' to be confused with ''Langerhans cells'' | | '''not''' to be confused with ''Langerhans cells'', Named after Theodor Langhans | ||
| [[Image:Granulation_tissue_containg_a_poorly_formed_granuloma_with_a_Langhan%27s_giant_cell.jpg|thumb|200px|LGC (WC)]] | | [[Image:Granulation_tissue_containg_a_poorly_formed_granuloma_with_a_Langhan%27s_giant_cell.jpg|thumb|200px|LGC (WC)]] | ||
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| Osteoclast-like giant cells | | Osteoclast-like giant cells | ||
| | | multiple bland central nuclei, ruffled cell membrane. | ||
| osteoclasts, others | | osteoclasts, others | ||
| [[AKA]] osteoclast-type giant cells | | [[AKA]] osteoclast-type giant cells | ||