Primary mediastinal B-cell lymphoma: Difference between revisions
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Features:<ref name=pmid19074109 >{{Cite journal | last1 = Johnson | first1 = PW. | last2 = Davies | first2 = AJ. | title = Primary mediastinal B-cell lymphoma. | journal = Hematology Am Soc Hematol Educ Program | volume = | issue = | pages = 349-58 | month = | year = 2008 | doi = 10.1182/asheducation-2008.1.349 | PMID = 19074109 }}</ref><ref name=pmid20207294>{{Cite journal | last1 = Coso | first1 = D. | last2 = Rey | first2 = J. | last3 = Bouabdallah | first3 = R. | title = [Primary mediastinal B-cell lymphoma] | journal = Rev Pneumol Clin | volume = 66 | issue = 1 | pages = 32-5 | month = Feb | year = 2010 | doi = 10.1016/j.pneumo.2009.12.007 | PMID = 20207294 }}</ref> | Features:<ref name=pmid19074109 >{{Cite journal | last1 = Johnson | first1 = PW. | last2 = Davies | first2 = AJ. | title = Primary mediastinal B-cell lymphoma. | journal = Hematology Am Soc Hematol Educ Program | volume = | issue = | pages = 349-58 | month = | year = 2008 | doi = 10.1182/asheducation-2008.1.349 | PMID = 19074109 }}</ref><ref name=pmid20207294>{{Cite journal | last1 = Coso | first1 = D. | last2 = Rey | first2 = J. | last3 = Bouabdallah | first3 = R. | title = [Primary mediastinal B-cell lymphoma] | journal = Rev Pneumol Clin | volume = 66 | issue = 1 | pages = 32-5 | month = Feb | year = 2010 | doi = 10.1016/j.pneumo.2009.12.007 | PMID = 20207294 }}</ref> | ||
*Rare. | *Rare. | ||
*Young adults | *Young adults, more common in females (M:F = 1:2) | ||
*[[Mediastinum]]. | *[[Mediastinum]] | ||
It is distinguished from DLBCL based on the patient demographics, radiological staging (showing mainly mediastinal disease) and immunoprofile (typically CD23+/CD30+). PMBCL has a better prognosis than DLBCL. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Atypical large lymphoid cells - | *Atypical large lymphoid cells - may be morphologically indistinguishable from ''[[DLBCL]]'' | ||
*Classically associated with: | *Classically associated with: | ||
**Fibrosis | **Fibrosis | ||
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DDx: | DDx: | ||
*Other types of [[DLBCL]] | *Other types of [[DLBCL]] (radiological assessment is important - PMBCL is centred in the mediastinum) | ||
*B-cell lymphoma with features intermediate between [[DLBCL]] and classical Hodgkins lymphoma | |||
*Poorly differentiated carcinoma. | *Poorly differentiated carcinoma. | ||
==IHC== | |||
*Pan B-cell markers | |||
*CD10 in minority (~20%) | |||
*CD23 and CD30 expression more common (~70% and ~85% respectively) | |||
*EBV negative | |||
===Images=== | ===Images=== | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Lymphoma]] | [[Category:Lymphoma]] | ||