Difference between revisions of "Pseudoinvasion in colorectal adenomatous polyps"
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'''Pseudoinvasion in colorectal adenomatous polyps''' is a mimic of invasive adenocarcinoma. | '''Pseudoinvasion in colorectal adenomatous polyps''', also '''epithelial misplacement''',<ref name=pmid25123305>{{Cite journal | last1 = Loughrey | first1 = MB. | last2 = Shepherd | first2 = NA. | title = The pathology of bowel cancer screening. | journal = Histopathology | volume = 66 | issue = 1 | pages = 66-77 | month = Jan | year = 2015 | doi = 10.1111/his.12530 | PMID = 25123305 }}</ref> is a mimic of (invasive) [[colorectal adenocarcinoma]]. | ||
'''Pseudoinvasion''' | '''Pseudoinvasion''' redirects to this article. | ||
==General== | ==General== | ||
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DDx: | DDx: | ||
*[[Gastrointestinal_tract_polyps#Colorectal_adenocarcinoma|Colorectal adenocarcinoma]]. | *[[Gastrointestinal_tract_polyps#Colorectal_adenocarcinoma|Colorectal adenocarcinoma]]. | ||
**Adenoma-like adenocarcinoma.<ref name=pmid25913616>{{Cite journal | last1 = Gonzalez | first1 = RS. | last2 = Cates | first2 = JM. | last3 = Washington | first3 = MK. | last4 = Beauchamp | first4 = RD. | last5 = Coffey | first5 = RJ. | last6 = Shi | first6 = C. | title = Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation. | journal = Histopathology | volume = 68 | issue = 2 | pages = 183-90 | month = Jan | year = 2016 | doi = 10.1111/his.12725 | PMID = 25913616 }}</ref> | |||
==IHC=== | |||
*MMP-1, p53, E-cadherin, collagen IV - may have some utility.<ref name=pmid11812942>{{Cite journal | last1 = Yantiss | first1 = RK. | last2 = Bosenberg | first2 = MW. | last3 = Antonioli | first3 = DA. | last4 = Odze | first4 = RD. | title = Utility of MMP-1, p53, E-cadherin, and collagen IV immunohistochemical stains in the differential diagnosis of adenomas with misplaced epithelium versus adenomas with invasive adenocarcinoma. | journal = Am J Surg Pathol | volume = 26 | issue = 2 | pages = 206-15 | month = Feb | year = 2002 | doi = | PMID = 11812942 }}</ref> | |||
**Probably not useful for difficult cases. | |||
==Sign out== | ==Sign out== | ||
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==See also== | ==See also== | ||
*[[Gastrointestinal tract polyps]]. | *[[Gastrointestinal tract polyps]]. | ||
*[[Intramucosal adenocarcinoma of the colon]]. | |||
==References== | ==References== |
Latest revision as of 06:27, 19 March 2018
Pseudoinvasion in colorectal adenomatous polyps, also epithelial misplacement,[1] is a mimic of (invasive) colorectal adenocarcinoma.
Pseudoinvasion redirects to this article.
General
Microscopic
Features - classic:[4]
- Dysplastic glands surrounded by lamina propria.
- Hemosiderin.
- Lack of desmoplastic reaction.
- +/-Cystic spaces with rounded contours without cells floating in them.
Memory device (classic features) LDH:
- Lamina propria.
- Desmoplasia lacking.
- Hemosiderin.
DDx:
- Colorectal adenocarcinoma.
- Adenoma-like adenocarcinoma.[5]
IHC=
- MMP-1, p53, E-cadherin, collagen IV - may have some utility.[6]
- Probably not useful for difficult cases.
Sign out
Note:
- The term pseudoinvasion may be confusing to clinicians.
COLON POLYP, SIGMOID COLON AT 45 CM, EXCISION: - TUBULAR ADENOMA. -- NEGATIVE FOR HIGH-GRADE DYSPLASIA. - SUBMUCOSA PRESENT, NO EVIDENCE OF INVASION. - ABUNDANT HEMOSIDERIN-LADEN MACROPHAGES.
Alternate
POLYP, SIGMOID COLON, EXCISION: - LARGE TUBULAR ADENOMA. -- NEGATIVE FOR HIGH-GRADE DYSPLASIA. - SCANT BENIGN SUBMUCOSA. - DEEP HEMOSIDERIN-LADEN MACROPHAGES.
See also
References
- ↑ Loughrey, MB.; Shepherd, NA. (Jan 2015). "The pathology of bowel cancer screening.". Histopathology 66 (1): 66-77. doi:10.1111/his.12530. PMID 25123305.
- ↑ Byun, TJ.; Han, DS.; Ahn, SB.; Cho, HS.; Eun, CS.; Jeon, YC.; Sohn, JH.; Oh, YH. (Jun 2009). "Pseudoinvasion in an adenomatous polyp of the colon mimicking invasive colon cancer.". Gut Liver 3 (2): 130-3. doi:10.5009/gnl.2009.3.2.130. PMC PMC2852693. PMID 20431736. https://www.ncbi.nlm.nih.gov/pmc/articles/PMCPMC2852693/.
- ↑ Odze, Robert D.; Goldblum, John R. (2009). Surgical pathology of the GI tract, liver, biliary tract and pancreas (2nd ed.). Saunders. pp. 512. ISBN 978-1416040590.
- ↑ Muto, T.; Bussey, HJ.; Morson, BC. (Jan 1973). "Pseudo-carcinomatous invasion in adenomatous polyps of the colon and rectum.". J Clin Pathol 26 (1): 25-31. PMC 477644. PMID 4540378. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC477644/.
- ↑ Gonzalez, RS.; Cates, JM.; Washington, MK.; Beauchamp, RD.; Coffey, RJ.; Shi, C. (Jan 2016). "Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation.". Histopathology 68 (2): 183-90. doi:10.1111/his.12725. PMID 25913616.
- ↑ Yantiss, RK.; Bosenberg, MW.; Antonioli, DA.; Odze, RD. (Feb 2002). "Utility of MMP-1, p53, E-cadherin, and collagen IV immunohistochemical stains in the differential diagnosis of adenomas with misplaced epithelium versus adenomas with invasive adenocarcinoma.". Am J Surg Pathol 26 (2): 206-15. PMID 11812942.