Difference between revisions of "Mucinous cystadenoma of the ovary"

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| IHC        =
| IHC        =
| EM        =
| EM        =
| Molecular  =
| Molecular  = +/-[[KRAS mutation]]
| IF        =
| IF        =
| Gross      = multiloculated cystic lesion, thin cyst walls/no solid areas
| Gross      = multiloculated cystic lesion, thin cyst walls/no solid areas
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Note:
Note:
*A borderline component may be present but '''must be <10%''' of the tumour.<ref name=Ref_GP>{{Ref GP|416}}</ref>
*A borderline component may be present but ''must be <10%'' of the tumour.<ref name=Ref_GP>{{Ref GP|416}}</ref>
**Lesions with <10% borderline component are known as ''mucinous cystadenoma of the ovary with focal proliferation'' or ''mucinous cystadenoma of the ovary with focal atypia''.
**Lesions with <10% borderline component are known as ''mucinous cystadenoma of the ovary with focal proliferation'' or ''mucinous cystadenoma of the ovary with focal atypia''.


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Image: Ovarian mucinous cystadenoma - a3- very high mag.jpg | OMC - very high mag.
Image: Ovarian mucinous cystadenoma - a3- very high mag.jpg | OMC - very high mag.
</gallery>
</gallery>
==Molecular==
*[[KRAS mutation]]s common ~ 56% of mucinous cystadenomas in one series.<ref name=pmid9118042>{{Cite journal  | last1 = Cuatrecasas | first1 = M. | last2 = Villanueva | first2 = A. | last3 = Matias-Guiu | first3 = X. | last4 = Prat | first4 = J. | title = K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases. | journal = Cancer | volume = 79 | issue = 8 | pages = 1581-6 | month = Apr | year = 1997 | doi =  | PMID = 9118042 }}</ref>


==Sign out==
==Sign out==
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Left Ovarian Cyst, Excision:
Left Ovarian Cyst, Excision:
- Mucinous cystadenoma.
- Mucinous cystadenoma.
</pre>
===Mucinous cystadenoma with focal proliferation===
<pre>
Left Ovarian Cyst, Excision:
- Mucinous cystadenoma with focal proliferation, see comment.
Comment:
The proliferative component is less than 10% of the lesion.
</pre>
</pre>


==See also==
==See also==
*[[Ovarian tumours]].
*[[Ovarian tumours]].
*[[Mucinous ovarian tumours]].
*[[Mucinous cystadenoma]].
*[[Mucinous cystadenoma]].
*[[Mucinous cystadenoma of the appendix]].
*[[Mucinous cystadenoma of the appendix]].

Latest revision as of 16:36, 1 March 2018

Mucinous cystadenoma of the ovary
Diagnosis in short

Ovarian mucinous cystadenoma. H&E stain.
LM cysts lined by a simple mucinous epithelium, no cytologic atypia
LM DDx seromucinous borderline tumour of the ovary, mucinous borderline tumour of the ovary
Molecular +/-KRAS mutation
Gross multiloculated cystic lesion, thin cyst walls/no solid areas
Site ovary - see ovarian tumours
Prevalence common
Prognosis benign
Clin. DDx other ovarian tumours - esp. mucinous ones, and mucinous appendiceal lesions
Treatment cystectomy/oophorectomy

Mucinous cystadenoma of the ovary, also ovarian mucinous cystadenoma, is a common benign ovarian tumour.

It is unrelated to mucinous cystadenoma of the appendix.

General

  • Common.[1]
    • Approximately 80% of all mucinous ovarian tumours.[2]
  • Benign.

Gross

  • Usually multiloculated.
  • May be very large large.[3]
  • No solid areas/thin cyst walls.

Images

  • Mucinous cystadenoma of the ovary. (WC)

Microscopic

Features:

  • Cysts lined by a simple mucinous epithelium.
  • No cytologic atypia.

Note:

  • A borderline component may be present but must be <10% of the tumour.[4]
    • Lesions with <10% borderline component are known as mucinous cystadenoma of the ovary with focal proliferation or mucinous cystadenoma of the ovary with focal atypia.

DDx:

Images

  • OMC - low mag.

  • OMC - low mag.

  • OMC - intermed. mag.

  • OMC - high mag.

  • OMC - intermed. mag.

  • OMC - high mag.

  • OMC - high mag.

  • OMC - very high mag.

Molecular

Sign out

Left Ovarian Cyst, Excision:
	- Mucinous cystadenoma.

Mucinous cystadenoma with focal proliferation

Left Ovarian Cyst, Excision:
	- Mucinous cystadenoma with focal proliferation, see comment.

Comment:
The proliferative component is less than 10% of the lesion.

See also

References

  1. ↑ Pongsuvareeyakul, T.; Khunamornpong, S.; Settakorn, J.; Sukpan, K.; Suprasert, P.; Siriaunkgul, S. (Mar 2012). "Accuracy of frozen-section diagnosis of ovarian mucinous tumors.". Int J Gynecol Cancer 22 (3): 400-6. doi:10.1097/IGC.0b013e31823dc328. PMID 22246404.
  2. ↑ Hart WR (January 2005). "Mucinous tumors of the ovary: a review". Int. J. Gynecol. Pathol. 24 (1): 4–25. PMID 15626914.
  3. ↑ Leys, CM.; Gasior, AC.; Hornberger, LL.; St Peter, SD. (Apr 2012). "Laparoscopic resection of massive ovarian mucinous cystadenoma.". J Laparoendosc Adv Surg Tech A 22 (3): 307-10. doi:10.1089/lap.2011.0435. PMID 22283565.
  4. ↑ Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 416. ISBN 978-0443069208.
  5. ↑ Cuatrecasas, M.; Villanueva, A.; Matias-Guiu, X.; Prat, J. (Apr 1997). "K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases.". Cancer 79 (8): 1581-6. PMID 9118042.

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