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Difference between revisions of "Mucinous cystadenoma of the ovary"
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Mucinous cystadenoma of the ovary (view source)
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Ovarian mucinous cystadenoma - a2 -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Ovarian mucinous cystadenoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = cysts lined by a simple mucinous epithelium, no cytologic atypia | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[seromucinous borderline tumour of the ovary]], [[mucinous borderline tumour of the ovary]] | | LMDDx = [[seromucinous borderline tumour of the ovary]], [[mucinous borderline tumour of the ovary]] | ||
| Line 11: | Line 11: | ||
| IHC = | | IHC = | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = +/-[[KRAS mutation]] | ||
| IF = | | IF = | ||
| Gross = | | Gross = multiloculated cystic lesion, thin cyst walls/no solid areas | ||
| Grossing = | | Grossing = | ||
| Site = [[ovary]] - see ''[[ovarian tumours]]'' | | Site = [[ovary]] - see ''[[ovarian tumours]]'' | ||
| Line 27: | Line 27: | ||
| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = other [[ovarian tumours]] - esp. mucinous ones, and mucinous appendiceal lesions | ||
| Tx = | | Tx = cystectomy/oophorectomy | ||
}} | }} | ||
'''Mucinous cystadenoma of the ovary''', also '''ovarian mucinous cystadenoma''', is a common benign [[ovarian tumours|ovarian tumour]]. | '''Mucinous cystadenoma of the ovary''', also '''ovarian mucinous cystadenoma''', is a common benign [[ovarian tumours|ovarian tumour]]. | ||
It is unrelated to [[mucinous cystadenoma of the appendix]]. | |||
==General== | ==General== | ||
*Common.<ref>{{Cite journal | last1 = Pongsuvareeyakul | first1 = T. | last2 = Khunamornpong | first2 = S. | last3 = Settakorn | first3 = J. | last4 = Sukpan | first4 = K. | last5 = Suprasert | first5 = P. | last6 = Siriaunkgul | first6 = S. | title = Accuracy of frozen-section diagnosis of ovarian mucinous tumors. | journal = Int J Gynecol Cancer | volume = 22 | issue = 3 | pages = 400-6 | month = Mar | year = 2012 | doi = 10.1097/IGC.0b013e31823dc328 | PMID = 22246404 }}</ref> | *Common.<ref name=pmid22246404>{{Cite journal | last1 = Pongsuvareeyakul | first1 = T. | last2 = Khunamornpong | first2 = S. | last3 = Settakorn | first3 = J. | last4 = Sukpan | first4 = K. | last5 = Suprasert | first5 = P. | last6 = Siriaunkgul | first6 = S. | title = Accuracy of frozen-section diagnosis of ovarian mucinous tumors. | journal = Int J Gynecol Cancer | volume = 22 | issue = 3 | pages = 400-6 | month = Mar | year = 2012 | doi = 10.1097/IGC.0b013e31823dc328 | PMID = 22246404 }}</ref> | ||
**Approximately 80% of all mucinous ovarian tumours.<ref name=pmid15626914>{{cite journal |author=Hart WR |title=Mucinous tumors of the ovary: a review |journal=Int. J. Gynecol. Pathol. |volume=24 |issue=1 |pages=4–25 |year=2005 |month=January |pmid=15626914 |doi= |url=}}</ref> | |||
*Benign. | *Benign. | ||
| Line 39: | Line 42: | ||
*Usually multiloculated. | *Usually multiloculated. | ||
*May be very large large.<ref name=pmid22283565>{{Cite journal | last1 = Leys | first1 = CM. | last2 = Gasior | first2 = AC. | last3 = Hornberger | first3 = LL. | last4 = St Peter | first4 = SD. | title = Laparoscopic resection of massive ovarian mucinous cystadenoma. | journal = J Laparoendosc Adv Surg Tech A | volume = 22 | issue = 3 | pages = 307-10 | month = Apr | year = 2012 | doi = 10.1089/lap.2011.0435 | PMID = 22283565 }}</ref> | *May be very large large.<ref name=pmid22283565>{{Cite journal | last1 = Leys | first1 = CM. | last2 = Gasior | first2 = AC. | last3 = Hornberger | first3 = LL. | last4 = St Peter | first4 = SD. | title = Laparoscopic resection of massive ovarian mucinous cystadenoma. | journal = J Laparoendosc Adv Surg Tech A | volume = 22 | issue = 3 | pages = 307-10 | month = Apr | year = 2012 | doi = 10.1089/lap.2011.0435 | PMID = 22283565 }}</ref> | ||
*No solid areas. | *No solid areas/thin cyst walls. | ||
===Images=== | |||
<gallery> | |||
Image:Mucinous Cystadenoma of Ovary (218889489).jpg | Mucinous cystadenoma of the ovary. (WC) | |||
</gallery> | |||
==Microscopic== | ==Microscopic== | ||
| Line 45: | Line 53: | ||
*Cysts lined by a simple mucinous epithelium. | *Cysts lined by a simple mucinous epithelium. | ||
*No cytologic atypia. | *No cytologic atypia. | ||
Note: | |||
*A borderline component may be present but ''must be <10%'' of the tumour.<ref name=Ref_GP>{{Ref GP|416}}</ref> | |||
**Lesions with <10% borderline component are known as ''mucinous cystadenoma of the ovary with focal proliferation'' or ''mucinous cystadenoma of the ovary with focal atypia''. | |||
DDx: | DDx: | ||
*[[Seromucinous borderline tumour of the ovary]]. | *[[Seromucinous borderline tumour of the ovary]]. | ||
*[[Mucinous borderline tumour of the ovary]]. | *[[Mucinous borderline tumour of the ovary]]. | ||
===Images=== | |||
<gallery> | |||
Image: Ovarian mucinous cystadenoma - alt -- low mag.jpg | OMC - low mag. | |||
Image: Ovarian mucinous cystadenoma -- low mag.jpg | OMC - low mag. | |||
Image: Ovarian mucinous cystadenoma -- intermed mag.jpg | OMC - intermed. mag. | |||
Image: Ovarian mucinous cystadenoma -- high mag.jpg | OMC - high mag. | |||
Image: Ovarian mucinous cystadenoma - a2 -- intermed mag.jpg | OMC - intermed. mag. | |||
Image: Ovarian mucinous cystadenoma - a2 -- high mag.jpg | OMC - high mag. | |||
Image: Ovarian mucinous cystadenoma - a3 -- high mag.jpg | OMC - high mag. | |||
Image: Ovarian mucinous cystadenoma - a3- very high mag.jpg | OMC - very high mag. | |||
</gallery> | |||
==Molecular== | |||
*[[KRAS mutation]]s common ~ 56% of mucinous cystadenomas in one series.<ref name=pmid9118042>{{Cite journal | last1 = Cuatrecasas | first1 = M. | last2 = Villanueva | first2 = A. | last3 = Matias-Guiu | first3 = X. | last4 = Prat | first4 = J. | title = K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases. | journal = Cancer | volume = 79 | issue = 8 | pages = 1581-6 | month = Apr | year = 1997 | doi = | PMID = 9118042 }}</ref> | |||
==Sign out== | |||
<pre> | |||
Left Ovarian Cyst, Excision: | |||
- Mucinous cystadenoma. | |||
</pre> | |||
===Mucinous cystadenoma with focal proliferation=== | |||
<pre> | |||
Left Ovarian Cyst, Excision: | |||
- Mucinous cystadenoma with focal proliferation, see comment. | |||
Comment: | |||
The proliferative component is less than 10% of the lesion. | |||
</pre> | |||
==See also== | ==See also== | ||
*[[Ovarian tumours]]. | *[[Ovarian tumours]]. | ||
*[[Mucinous ovarian tumours]]. | |||
*[[Mucinous cystadenoma]]. | |||
*[[Mucinous cystadenoma of the appendix]]. | *[[Mucinous cystadenoma of the appendix]]. | ||